Publications PD Dr. Tränkle

2018

Irmen M, Holze J, Bödefeld T, Tränkle C. Characterization of methanthelinium binding and function at human M1-M5 muscarinic acetylcholine receptors. Naunyn Schmiedebergs Arch Pharmacol. 2018 Jun 24.

2017

De Min A, Matera C, Bock A, Holze J, Kloeckner J, Muth M, Tränkle C, De Amici M, Kenakin T, Holzgrabe U, Dallanoce C, Kostenis E, Mohr K, Schrage R. (2017) A New Molecular Mechanism To Engineer Protean Agonism at a G Protein-Coupled Receptor. Mol Pharmacol. 91(4):348-356.

Messerer R, Dallanoce C, Matera C, Wehle S, Flammini L, Chirinda B, Bock A, Irmen M, Tränkle C, Barocelli E, Decker M, Sotriffer C, De Amici M, Holzgrabe U. (2017) Novel bipharmacophoric inhibitors of the cholinesterases with affinity to the muscarinic receptors M1and M2. Medchemcomm 8(6):1346-1359.

2015

Keller M, Tränkle C, She X, Pegoli A, Bernhardt G, Buschauer A, Read RW. (2015) M2 Subtype preferring dibenzodiazepinone-type muscarinic receptor ligands: Effect of chemical homo-dimerization on orthosteric (and allosteric?) binding. Bioorg Med Chem. 23(14):3970-3990.

Chen X, Klöckner J, Holze J, Zimmermann C, Seemann WK, Schrage R, Bock A, Mohr K, Tränkle C, Holzgrabe U, Decker M. (2015) Rational design of partial agonists for the muscarinic m1 acetylcholine receptor. J Med Chem. 2015 58(2):560-576.

2014

Otto R, Penzis R, Gaube F, Winckler T, Appenroth D, Fleck C, Tränkle C, Lehmann J, Enzensperger C. (2014) Beta and gamma carboline derivatives as potential anti-Alzheimer agents: A comparison. Eur J Med Chem. 87:63-70.

Bock A, Kostenis E, Tränkle C, Lohse MJ, Mohr K. Pilot the pulse: controlling the multiplicity of receptor dynamics. (2014) Trends Pharmacol Sci. 35(12):630-638.

Schmitz J, van der Mey D, Bermudez M, Klöckner J, Schrage R, Kostenis E, Tränkle C, Wolber G, Mohr K, Holzgrabe U. (2014) Dualsteric muscarinic antagonists--orthosteric binding pose controls allosteric subtype selectivity. J Med Chem. 57(15):6739-6750.

Schrage R, Holze J, Klöckner J, Balkow A, Klause AS, Schmitz AL, De Amici M, Kostenis E, Tränkle C, Holzgrabe U, Mohr K.(2014) New insight into active muscarinic receptors with the novel radioagonist [³H]iperoxo. Biochem Pharmacol. 90(3):307-319.

Bock A, Chirinda B, Krebs F, Messerer R, Bätz J, Muth M, Dallanoce C, Klingenthal D, Tränkle C, Hoffmann C, De Amici M, Holzgrabe U, Kostenis E, Mohr K. (2014) Dynamic ligand binding dictates partial agonism at a G protein-coupled receptor. Nat Chem Biol. 10(1):18-20.