Eckhard Leistner (em.)

Selected publications

Biosynthesis of quinones in plants

E.Leistner and M.H. Zenk
Zur Biogenese von 5-Hydroxy-1,4-Naphthochinon (Juglon) in Juglans regia L.
Z. Naturf. 23B (2), 259-268 (1968)

E.Leistner
Mode of incorporation of precursors into alizarin (1,2-dihydroxy-9,10-anthraquinone)
Phytochemistry 12, 337-345 (1973)

E.Leistner and M.H.Zenk
Chrysophanol (1,8-dihydroxy-3-methylanthrachinone) biosynthesis in higher plants
Chemical Commun 210-211 (1969)

E.Leistner
Biosynthesis of morindone and alizarin in intact plants and cell suspension cutures of Morinda citrifolia
Phytochemistry 12, 1669-1674 (1973)

H.J.Bauch, R.P.Labadie, and E.Leistner
Biosynthesis of nepodine (2-acetyl-3-methylnaphthalene-1,8-diol) in Rumex alpinus L
J.Chem.Soc. Perkin I, 689-692 (1975)

W.U.Müller and E.Leistner
Metabolic relation between naphthalene dervatives in Juglans
Phytochemistry 17, 1739-1742, (1978)

W.U.Müller and E.Leistner
Aglycones and glycosides of oxygenated naphthalenes and a glycosyltransferase from Juglans
Phytochemistry 17, 1739-1742 (1978)

L.Heide and E.Leistner
Methoxycarbonyl-3-prenyl-1,4-naphthoquinone, a metabolite related to the biosynthesis of mollugin and anthraquinones in Galium mollugo L.
J.C.S. Chem. Commun 334-336 (1981)

L.Heide and E.Leistner
Versuche zur Synthese natürlich vorkommender prenylierter Naphthalinderivate. Nachweis eines neuen Prenylnaphthochinonderivates in Galium mollugo.
Z.Naturf. 37C, 354-362 (1982)

L.Heide, R.Kolkmann,S.Arendt, and E.Leistner
Enzymatic synthesis of o-succinylbenzoyl-CoA in cell-free extracts of anthraquinone producing Galium mollugo L.cell suspension cultures Plant Cell Reports 1, 180-182 (1982)

U.Igbavboa, H.J. Sieweke, E.Leistner, I. Röwer, W. Hüsemann, and W. Barz
Alternative formation of anthraquinones and lipoquinones in heterotrophic and photoautotrophic cell suspension cultures of Morinda lucida Benth.
Planta 166, 537-544 (1985)

H.Yamamoto, M.Tabata, E.Leistner
Cytological changes associated with induction of anthraquinone synthesis in photoautotrophic cell suspension cultures in Morinda lucida.
Plant Cell Reports 6, 187-190 (1987)

M.Simantiras, K. Schmidt, and E.Leistner
4-(2‘-carboxyphenyl)-4-oxobutyrate:preparative isolation from anthraquinone producing cell suspension cultures of Galium mollugo
Phytochemistry 30, 823-824 (1991)

M.Simantiras and E.Leistner
Formation of o-succinylbenzoic acid from iso-Chorismic acid in protein extracts from anthraquinone producing cell suspension cultures
Phytochemistry 28, 1381-1382 (1989)

C.Ledüc, I.Birgel, R. Müller, E.Leistner
Isochorismate hydroxymutase from a cell-suspension culture of Galium mollugo L.
Planta 202, 2016-210 (1997)

C.Ledüc, B.Ruhnau and E.Leistner
Isochorismat Synthase from Rubiaceae cell suspension cultures.
Plant Cell Reports 10, 334-337 (1991)

H.J.Sieweke and E.Leistner
o-Succinylbenzoate:coenzyme A ligase from anthraquinone producing cell suspension cultures of Galium mollugo
Phytochemistry 31, 2329-2335 (1992)

Reviews

H. Zenk and E.Leistner
Biosynthesis of quinones
Lloydia 31, 275-292 (1968)

E.Leistner
Quinonoid pigments
in: Pigments in plants. ed:F.-C.Czygan, G.Fischer, Stuttgart and NewYork 352-369 (1980)

E.Leistner
Biosynthesis of plant quinones in: The biochemistry of plants, a comprehensive treatise Vol 7, ed PK Stumpf and E.E.Conn.
Academic Press New York 1981,403-423

E.Leistner
Biosynthesis of chorismate-derived quinones in plant cell cultures in: Primary and Secondary Metabolism of Plant Cell Cultures, ed. Neumann et al.,
Springer, Berlin (1985), 215-224

E.Leistner
Occurrence and biosynthesis of quinones in woody plants. in:Biosynthesis and biodegradation of wood components, ed.T.Higuchi. Academic press, Orlando , 273-290(1985)

E.Leistner
Biosynthesis of iso-chorismate derived quinones in:Recent advances in phytochemistry, vol 20, the shikimc acid pathway, ed: E.E.Conn, Plenum New York, 243-261(1986)

H.Inouye and E.Leistner
Biochemistry of quinones in: The chemistry of quinonoid compounds Vol II, ed. S. Patai-Z. Rapoport. Wiley Chichester (1988), 1293-1349

E.Leistner
XVI Morinda species. Biosynthesis of quinones in cell cutures in: Biotechnology in agriculture and forestry, medicinal and aromatic plants VIII ed.Y.P.S. Bajaj
Springer BerlinVol 33 (1995) 296-307

Biotechnology and metabolism of isochorismic acid

P.M.M. Schaaf, L.Heide, Y.Tani, M.Karas, R. Deutzmann, and E.Leistner
Properties of isochorismate hydroxymutase from Flavobacterium K3-15
J.Nat.Prod. 56, 1294-1303 (1993)

P.M.M. Schaaf, L.E.Heide, E.W.Leistner
Immobilization of isochorismate hydroxymutase. Comparison of native versus immobilized enzyme
J.Nat.Prod. 56, 1304-1312 (1993)

K.Schmidt and E.Leistner
Microbial production of (+)-trans-isochorismic acid
Biotechnology and Bioengineering 45, 285-291 (1995)

R.Müller, M. Breuer, A. Wagener, K. Schmidt and E.Leistner
Bacterial production of trans-dihydroxycyclohexadiene carboxylates by metabolic pathway engineering
Microbiology 142, 1005-1012 (1996)

R.Müller, A.Wagener, K. Schmidt, and E.Leistner
Microbial production of specifically ring-13C-labelled 4-hydroxybenzoic acid
Appl. Microbiol Biotechnol 43, 985-988 (1995)

R.Müller, C.Dahm, G.Schulte, and E.Leistner
An isochorismate hydroxymutase isogene in Escherichia coli
FEBS Letters 378, 131-134 (1996)

C.Dahm, R.Müller, G.Schulte, K. Schmidt, E.Leistner
The role of isochorismate hydroxymutase genes entC and menF in enterobactin and menaquinone biosynthesis in Escherichia coli
Biochim Biophys Acta 1425, 377-386 (1998)

K.Buss, R.Müller, C. Dahm, N. Gaitatzis, E. Skrzypczak-Pietraszek, E. Lohmann, M. Gassen, E.Leistner
Clustering of isochorismate synthase genes menF and ent C and channeling of isochorismate in Escherichia coli
Biochim Biophys Acta 1522, 151-157 (2001)

Biosynthesis of vitamin K and Axenomycin A

A.Weische and E.Leistner
Cell free synthesis of o-succinylbenzoic acid from iso-chorismic acid, the key reaction in vitamin K2 (menaquinone) biosynthesis
Tetrahedron Letters 26 (12),1487-1490 (1985)

A.Weische, M. Johanni, and E.Leistner
Biosynthesis of o-succinylbenzoic acid I: Cellfree synthesis of o-succinylbenzoic acid from iso-chorismic acid in enzyme preparations from vitamin K producing bacteria
Arch Biochem Biophys 256, 212-222 (1987)

A.Weische, W.Garvert, and E.Leistner
Biosynthesis of o-succinylbenzoic acid II: Properties of o-succinylbenzoic acid synthase, an enzyme involved in vitamin K2 biosynthesis
Arch Biochem Biophys 256, 223-231 (1987)

L.Heide, S.Arendt, and E.Leistner
Enzymatic synthesis, characterization, and metabolism of the coenzyme A Ester of o-succinylbenzoic acid, an intermediate in menaquinone (vitamin K2) biosynthesis
J Biol Chem 257, 7396-7400 (1982)

R. Kolkmann and E.Leistner
Synthesis and revised structure of the o-succinylbenzoic acid coenzyme A ester, an intermediate in menaquinone biosynthesis
Tetrahedron Letters 26 (14), 1703-1704 (1985)

R.Kolkmann and E.Leistner
Synthesis, analysis and characterisation of the coenzyme A esters of o-succinylbenzoic acid, an intermediate in vitamin K2 (Menaquinone) biosynthesis
Z. Naturforsch. 42c, 542-552 (1987)

R.Kolkmann and E.Leistner
4-(2´-Carboxyphenyl)-4-oxobutyryl coenzyme A ester, an intermediate in vitamin K2 (Menaquinone) biosynthesis
Z. Naturforsch. 42c, 1207-1214 (1987)

U.Igbavboa and E.Leistner
Sequence of proton abstraction and stereochemistry of the reaction catalyzed by naphtoate synthase, an enzyme involved in menaquinone (vitamine K2) biosynthesis
Eur. J. Biochem. 192, 441-449 (1990) doi.org/10.1111/j.1432-1033.1990.tb19246.x

H.J. Bauch and E.Leistner
Bioproduction of Axenomycins in batch cultures of Streptomyces lisandri
Z. Naturforsch. 35C, 936-944 (1980)

V. Friese, A. Boos, H.-J. Bauch and E.Leistner
Biosynthesis of Axenomycin D. Incorporation of 13C-labelled precursors into the menadione chromophor, desoxysugar and the axenolide
Phytochemistry 32, 613-622 (1993)

Reviews

E. Leistner and M.H.Zenk
Biosynthesis of vitamin K2 in: Vitamins and coenzymes C,Methods in enzymologyXVII, ed:D.B.McCormick and L.D. Wright, Academic press, New York 574-559 (1971)

E.Leistner
The role of isochorismic acid in bacterial and plant metabolism in: Comprehensive Natural Products Chemistry, ed. D. Barton, K Nakanishi and U. Sankawa Vol1 Elsevier, Amsterdam (1999) 609-622

Biosynthesis of ansamycin antibiotics (with Heinz G. Floss, Seattle)

Chun-Gyu Kim, A. Kirschning, P. Bergon, Pei Zhou, Esther Su, B. Sauerbrei, Sandra Ning, Yonghyun Ahn, M. Breuer, E.Leistner and H.G.Floss
Biosynthesis of 3-Amino-5-hydroxybenzoic acid, the precursor of mC7N units in Ansamycin antibiotics
J.Am.Chem.Soc. 118, 7486-7491(1996)

Shuo Chen, D.von Bamberg, V. Hale, M. Breuer, B. Hardt, R. Müller, H. G.Floss, K.A. Reynolds and E.Leistner
Biosynthesis of ansatrienin (mycotrienin) and naphthomycin: identification and analysis of two separate biosynthetic gene clusters in Streptomyces collinus Tü 1892
Eur. J. Biochem. 260, 1-11 (1999)

Tin-Wein Yu, R. Müller, M. Müller, Xiaohong Zhang, G. Draeger, Chun-Gyu Kim, E.Leistner, and H.G.Floss
Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in Amycolatopsis mediterranei S699
J. Biol. Chem. 276, 12546-12555 (2001)

Tin-Wein Yu, Linquan Bai, D. Clade, D. Hoffmann, S. Toelzer, Khue Q. Trinh, Jun Xu, S.J. Moss, E.Leistner, and H.G.Floss
The biosynthetic gene cluster of the maytansinoid antitumor agent ansamyitocin from Actinosynnema pretiosum
Proc. Nat. Acad. Sci. 99, 7968-7973 (2002)

Review

J.M. Cassady, K.K. Chan, H.G. Floss, and E. Leistner
Recent developments in the maytansinoid antitumor agents
Chem. Pharm. Bull. 52, 1-26 (2004)

Stereospecific aspects of piperidin alkaloid biosynthesis

E.Leistner and I.D.Spenser
Biosynthesis of the piperidine nucleus. Incorporation of chirally labelled [1- 3H] cadaverine
J.Am.Chem.Soc. 95, 4715-4725(1973)

E.Leistner, R.N. Gupta, and I.D.Spenser
A general method for the determination of precursor configuration in biosynthetic precursor-product relationships. Derivation of L-pipecolic acid from D-lysine, and of piperidine alkaloids from L-lysine
J.Am.Chem.Soc. 95, 4040-4047 (1973)

E.Leistner and I.D.Spenser
The stereochemistry of the enzymic decarboxylation of L-lysine
J.Chem.Soc.Chem.Commun.378-379 (1975)

H.J.Gerdes and E.Leistner
Stereochemistry of reactions catalysed by L-lysinedecarboxylase and diamine oxidase
Phytochemistry 18, 771-775 (1978)

N.Fangmeier and E.Leistner
A 15N-NMR study on D-Lysine metabolism in Neurospora crassa
J.Biol.Chem. 255, 10205-10209 (1980)

Vitamin B6 and Ginkgotoxin

C.Drewke, C.Notheis, U.Hansen, E.Leistner, T.Hemscheidt, R.E.Hill, and I.D.Spenser
Growth response to 4-hydroxy-L-threonine of Escherichia coli mutants blocked in vitamin B6 biosynthesis
FEBS Letters 318, 125 (1993)

C.Notheis, C.Drewke, and E.Leistner
Purification and characterisation of the pyridoxol-5´-phosphate:oxygen oxidoreductase (deaminating) from Escherichia coli
Biochim Biophys Acta 1247, 265-271 (1995)

C.Drewke, M.Klein, D.Clade, A.Arenz, R.Müller, and E.Leistner
4-O-Phosphoryl-L-threonine, a substrate of the pdxC(serC) gene product involved in vitamin B6 biosynthesis
FEBS Letters 390, 179-182 (1996)

A.Arenz, M.Klein, K.Fiehe, J.Groß, C.Drewke, T.Hemscheidt, and E.Leistner
Occurrence of neurotoxic 4´-O-methylpyridoxine in Ginkgo biloba leaves, Ginkgo medications and Japanese Ginkgo food.
Planta medica 62, 548-551 (1996)

K.Fiehe, A. Arenz, C. Drewke, T.Hemscheidt, R.T. Williamson, and E.Leistner
Biosynthesis of 4′-O-methylpyridoxine (Ginkgotoxin) from primary precursors
J. Nat. Prod. 63, 185-189 (2000) doi.10.1021/np990414

K.Buss, C. Drewke, S. Lohmann, A.Piwonska, and E.Leistner
Properties and interaction of heterologously expressed glutamate decarboxylase isoenzymes GAD65kDa and GAD67kDA from human brain with ginkgotoxin and its 5‘-phosphate.
J Med Chem 44, 3166-3174 (2001) doi.10.1021/jm010868f

S.Wagner, A. Bernhardt, J.E.Leuendorf, C. Drewke, A. Lytovchenko, N. Mujahed, C. Gurgui, W.B. Frommer, E. Leistner, A.R.Fernie, and H. Hellmann
Analysis of the Arabidopsis rsr4-1/pdx1-3 mutant reveals the critical function of the PDX1 protein family in metabolism, development, and vitamin B6 biosynthesis.
The Plant Cell 18, 1722-1735 (2006) doi.10.1105/tpc.105.036269

J.E.Leuendorf, A. Genau, A. Szewczyk, S. Mooney, C. Drewke, E. Leistner, and H. Hellmann
The Pdx1 family is structurally and functionally conserved between Arabidopsis thaliana and Ginkgo biloba.
FEBS Journal 275, 960-969 (2008) doi.10.1111/j.1742-4658.2008.06275.x

N. Salamon, C. Gurgui, E.Leistner and C. Drewke
Influence of antivitamins ginkgotoxin 5’-phosphate and deoxypyridoxine 5’-phosphate on human pyridoxin 5’-phosphate oxidase.
Planta medica 75, 563-567 (2009) doi.10.1055/s-0029-1185482

U.Kästner, C.Hallmen, M.Wiese, E.Leistner, E and C.Drewke
The human pyridoxal kinase, a plausible target for ginkgotoxin from Ginkgo biloba
FEBS Journal 274, 1036-1045 (2007) doi.10.1111/j.1742-4658.2007.05654.x

Reviews

E. Leistner and C. Drewke
Ginkgo biloba and ginkgotoxin
J.Nat. Prod. 73, 86-92(2010) doi.10.1021/np9005019

C.Drewke, E. Leistner
Biosynthesis of Vitamin B6 and structurally related derivatives in: Vitamins and Hormones Vol 61, ed Tadhg Begley, Academic Press, San Diego 2001, p121-155.

Plant associated bacteria

C.Pullen, P.Schmitz, K.Meurer, D.D.v.Bamberg, S.Lohmann, S.DeCastro Franca, I.Groth, B.Schlegel, U.Möllmann, F.Gollmick, U.Gräfe, and E.Leistner
New and bioactive compounds from Streptomyces strains residing in the wood of Celastraceae
Planta 216, 162-167 (2002) doi.10.1007/s00425-002-0874-6

C.B.Pullen, P.Schmitz, D.Hoffmann, K.Meurer,T.Boettcher, D.v.Bamberg, A.M.Pereira, S.de Castro Franca, M.Hauser, H.Geertsema, A.van Wyk, T.Mahmud, H.G.Floss, and E.leistner
Occurrence and non-detectability of maytansinoids in individual plants of the genera Maytenus and Putterlickia
Phytochemistry 62, 377-387 (2003)

I.Groth, B.Schütze, T.Boettcher, C.B.Pullen, C.Rodriguez, E.Leistner, and M.Goodfellow
Kitasatospora putterlickiae sp. nov., isolated from rhizosphere soil, transfer of Streptomyces kifunensis to the genus Kitasatospora as Kitasatospora kifunensis comb.nov, and emended description of Streptomyces aureofaciens Duggar 1948
International Journal of Systematic and Evolutionary Microbiology 53, 2033-2040 (2003) doi.10.1099/ijs.0.02674-0

I. Groth, C.Rodriguez, B.Schütze, P. Schmitz, E.Leistner, M. Goodfellow
Five novel Kitasatospora species fron soil:Kitasatospora aborifhila sp.nov., K.gansuensis sp. nov., K.nipponensis sp. nov., K.paranensis sp.nov. and K.terrestris sp.nov.
International Journal of Systematic and Evolutionary Microbiology 54, 2121-2129 (2004) doi.10.1099/ijs.0.63070-0

S. Wings, H. Müller, G. Berg, M. Lamshoeft, and E. Leistner
A study of the bacterial community in the root system of the maytansine containing plant Putterlickia verrucosa.
Phytochemistry 91, 158-164 (2013). doi.org/10.1016/j.phytochem.2012.06.016

J.M.Cassady, K.K.Chan, H.G. Floss, and E.Leistner
Recent developments in the maytansinoid antitumor agents
Chem.Pharm.Bull. 52, 1-26 (2004)

The Symbiota Periglandula/Turbina and Periglandula/Ipomoea

S.Kucht, J.Groß, Y.Hussein, T.Grothe, U.Keller, S.Basar, W.A.König, U.Steiner, and E.Leistner
Elimination of ergoline alkaloids following treatment of Ipomoea asarifolia (Convolvulaceae) with fungicides.
Planta 219, 619-625 (2004) doi.10.1007/s00425-004-1261-2

U.Steiner, M.A.Ahimsa-Müller, A.Markert, S.Kucht, J.Groß, N.Kauf, M.Kuzma, M.Zych, M.Lamshöft, M.Furmanowa, V.Knoop, C.Drewke, and E.Leistner
Molecular characterisation of a seed transmitted clavicipitaceous fungus occurring on dicotyledonous plants (Convolvulaceae)
Planta 224, 533-544(2006) doi.10.1007/s00425-006-0241-0

M.A. Ahimsa-Müller, A. Markert, S. Hellwig, V. Knoop, U. Steiner, C. Drewke, and E. Leistner
Clavicipitaceous fungi associated with ergoline alkaloid-containing Convolvulaceae.
J. Nat. Prod. 70, 1955-1960 (2007). doi.10.1021/np070315t

A. Markert, N. Steffan, K. Ploss, S. Hellwig, U. Steiner, C. Drewke, Shu-Ming Li, W. Boland, and E. Leistner
Biosynthesis and accumulation of ergoline alkaloids in a mutualistic association between Ipomoea asarifolia (Convolvulaceae) and a clavicipitalean fungus.
Plant physiol.147, 296-305 (2008). doi.10.1104/pp.108.116699

U. Steiner, S. Hellwig, and E. Leistner
Specificity in the interaction between an epibiotic clavicipitalean fungus and its convolvulaceous host in a fungus/plant symbiotum.
Plant Signalling & Behaviour 3, 704-706 (2008).

U.Steiner, S. Leibner, C.L. Schardl, A. Leuchtmann, E. Leistner
Periglandula, a new fungal genus within the Clavicipitaceae and its association with Convolvulaceae.
Mycologia 103, 1135-1145 (2011). doi. 10.3852/11-031

Christopher L. Schardl, Carolyn A. Young, Uljana Hesse, Stefan G. Amyotte, Kalina Andreeva, Patrick J. Calie, Damien J. Fleetwood, David C. Haws, Neil Moore, Birgitt Oeser, Daniel G. Panaccione, Kathryn K. Schweri, Christine R. Voisey, Mark L. Farman, Jerzy W. Jaromczyk, Bruce A. Roe, Donal M. O'Sullivan, Barry Scott, Paul Tudzynski, Zhiqiang An, Elissaveta G. Arnaoudova, Charles T. Bullock, Nikki D. Charlton, Li Chen, Murray Cox, Randy D. Dinkins, Simona Florea, Anthony E. Glenn, Anna Gordon, Ulrich Güldener, Daniel R. Harris, Walter Hollin, Jolanta Jaromczyk, Richard D. Johnson, Anar K. Khan, Eckhard Leistner, Adrian Leuchtmann, Chunjie Li, JinGe Liu, Jinze Liu, Miao Liu, Wade Mace, Caroline Machado, Padmaja Nagabhyru, Juan Pan, Jan Schmid, Koya Sugawara, Ulrike Steiner, Johanna E. Takach, Eiji Tanaka, Jennifer S. Webb, Ella V. Wilson, Jennifer L. Wiseman, Ruriko Yoshida, Zheng Zeng
Plant-symbiotic fungi as chemical engineers: Multi-genome analysis of the Clavicipitaceae reveals dynamics of alkaloid loci.
PLoS Genet 9(2): e1003323. Doi:10.1371/journal.pgen.1003323.

U. Steiner, S. Hellwig neé Kucht, M.A. Ahimsa-Müller, N. Grundmann, Shu-Ming Li, C. Drewke, and E. Leistner
The key role of glandular trichomes in symbiota comprising Clavicipitaceous fungi of the genus Periglandula and their host plants
Toxins 7, 1355-1373, (2015). doi.10.3390/toxins7041355

 
Reviews

E. Leistner and U. Steiner
Fungal origin of ergoline alkaloids present in dicotyledonous plants (Convolvulaceae). Chapter 9 in The Mycota XV, Physiology and Genetics, 1st edition, T.Anke and D.Weber ,eds., Springer, Berlin Heidelberg (2009) p 197-208.

U. Steiner, and E. Leistner
Ergoline alkaloids in convolvulaceous host plants originate from epibiotic clavicipitaceous fungi of the genus Periglandula
Fungal Ecology 5, 316-321 (2012). doi.10.1016/j.funeco.2011.04.004

E. Leistner, U.Steiner
The genus Periglandula and its symbiotum with Morning Glory Plants (Convolvulaceae) in T.Anke, A.Schüffler (Eds.) The Mycota XV, Physiology and Genetics, 2nd edition, p 131-147 (2018). doi.10.1007/978-3-319-71740-15

U.Steiner, E.Leistner
Ergot alkaloids and their hallucinogenic potential in Morning Glories
Planta medica 84, 751-758 (2018) doi.10.1055/a-0577-8049

Lehrbuch Leistner-Breckle (8. Auflage)
Pharmazeutische Biologie kompakt, Grundlagen/Systematik/Humanbiologie

begründet von Eckhard Leistner, Bonn und Sigmar-W. Breckle, Bielefeld

Bearbeitet von Gisela Drews, Tübingen, Michael Keusgen, Marburg, Christel Drewke, Bonn, Peter Krippeit-Drews, Tübingen

Wissenschaftliche Verlagsgesellschaft, Stuttgart, 2014