Publikationen der AG König
2023
Glucose-stimulted inulin secretion depends on FFA1 and Gq in neonatal mous islets
E. Lorza-Gil; G. Kaiser; C. Carlein; M. D. A. Hoffmann; G. M. König; S. Haug; L. Prates Roma; E. Rexen Ulven; T. Ulven; E. Kostenis; A. L. Birkenfeld; H.-U. Häring; S- Ullrich; F. Gerst.
Diabetologia 2023, doi: 0.1007/s00125-023-05932-5.
Structure-affinity and structure-residence time relationships of macrocyclic Gαq protein inhibitors
J. H. Voss, M. Crüsemann, C. R.O. Bartling, S. Kehraus, A. Inoue, G. M. König, K. Strømgaard, C. E. Müller
IScience 2023, 106492.
Is a modified actin the key to toxin resistance in the nudibranch Chromodoris? A biochemical and molecular approach.
C. Hertzer, N. I. J. Undap, A. Papu, D. Ram Bhandari, S. Aatz, S. Kehraus, F. Kaligis, R. Bara, T. F. Schäberle, H. Wägele, G. M. König
Diversity 2023, 15, 304.
Pharmacokinetics and pharmacodynamics (PK/PD) of corallopyronin A against methicillin-resistant Staphylococcus aureus
K. Rox, T. Becker, A. Schiefer, M. Grosse, A. Ehrens, R. Jansen, T. Aden, S. Kehraus, G. M. König, A. K. Krome, M. P. Hübner, K. G. Wagner, M. Stadler, K. Pfarr, A. Hoerauf
Pharmaceutics 2023, 15, 131
Imaging of Gαq proteins in mouse and human organs and tissues
J. H. Voss, H. Al-Hroub, R. Gedschold, J. M. Dietrich, E. Gaffal, M. Toma, S. Kehraus, G. M. König, P. Brust, B. K. Fleischmann, D. Wenzel, W. Deuther-Conrad, C. E. Müller
Pharmaceutics 2023, 15, 57.
2022
Oxytocin-Modulated Ion Channel Ensemble Controls Depolarization, Integration and Burst Firing in CA2 Pyramidal Neurons.
J.-J. Liu, K. W. Eyring, G. M. König, E. Kostenis, R. W. Tsien.
J. Neurosci. 2022, 42, 7707–7720.
Pharmacology and early ADMET data of corallopyronin A, a natural product with macrofilaricidal anti-wolbachial activity in filarial nematodes
A. Ehrens, A. Schiefer, A. K. Krome, T. Becker, K. Rox, H. Neufeld, T. Aden, K. G. Wagne, R. Müller, M. Grosse, M. Stadler, G. M. König, S. Kehraus, S. Alt, T. Hesterkamp, M. P. Hübner, K. Pfarr, A. Hoerauf
Front. Trop. Dis. 2022, 3. 983107.
In vitro–In vivo relationship in mini-scale—enabling formulations of corallopyronin A
T, Becker; A. K. Krome; S. Vahdati; A. Schiefer; K. Pfarr; A. Ehrens; T. Aden; M. Grosse; R. Jansen; S. Alt; T. Hesterkamp; M. Stadler; M. P. Hübner; S. Kehraus; G. M. König; A. Hoerauf; K. G. Wagner
Pharmaceutics 2022, 14, 1657.
The RNA polymerase inhibitor corallopyronin A has a lower frequency of resistance than rifampicin in Staphylococcus aureus
J. Balansky; K. Pfarr; C. Szekat; S. Kehraus; T. Aden; M. Grosse; R. Jansen; T. Hesterkamp; A. Schiefer; G. M. König; M. Stadler; A. Hoerauf; G. Bierbaum
Anibiotics 2022, 11, 920.
Corallopyronin A: antimicrobial discovery to preclinical development
A. K. Krome, T. Becker, S. Kehraus, A. Schiefer, M. Gütschow, L. Chaverra-Muñoz, S. Hüttel, R. Jansen, M. Stadler, A. Ehrens, D. Pogorevc, R. Müller, M. P. Hübner, T. Hesterkamp, K. Pfarr, A. Hoerauf, K. G. Wagner, G. M. König
Nat. Prod. Rep. 2022, 39, 1705-1720.
Selective optogenetic control of Gq signaling using human Neuropsin
A. Wagdi; D. Malan; U. Sathyanarayanan; J. S. Beauchamp; M. Vogt; D. Zipf; T. Beiert; B. Mansuroglu; V. Dusend; M. Meininghaus; L. Schneider; B. Kalthof; J. S. Wiegert; G. M. König; E. Kostenis; R. Patejdl; P. Sasse; T. Bruegmann
Nature Commun. 2022, 13, 1765.
Adipocyte Gq siganling is a regulator of glucose and lipid homeostasis in mice
T. Kimura; S. P. Pydi; L. Wang; D. Haspula; Y. Cui; H. Lu; G. M. König; E. Kostenis; G. R. Steinberg; O. Gavrilova, J. Wess
Nature Commun. 2022, 13, 1652.
Phyllidiidae (Nudibranchia, Heterobranchia, Gastropoda): an integrative taxonomic approach including chemical analyses
A. Papu; A. Bogdanov; R. Bara; S. Kehraus; G. M. König;· N. Yonow; H. Wägele
Organisms Diversity & Evolution. doi: 10.1007/s13127-021-00535-7.
A specialized dehydrogenase provides l-phenyllactate for FR900359 biosynthesis
S. Klöppel; R. Richarz; D. A. Wirtz; N. Vasenda; G. M. König; M. Crüsemann
ChemBioChem 2022, 23, e.202100569.
2021
Disentangling bias between Gq, GRK2 and arrestin3 recruitment to the M3 muscarinic acetylcholine receptor
A. Floeser; K. Becker; E. Kostenis; G. M. König; C. Krasel; P. Kolb; M. Buenemann
eLife 2021,10, e58442.
Gq siganling in a-cells is critical for maintaining euglycemia
L. Liu; D. Dattory; K. F. Simpson; L. F. Barella; Y. Cui; Y. Xiong; J. Jin; G. M. König; E. Kostenis; C. Roman; K. H. Kaestner; N. M. Doliba; J. Wess
JCI insight 2021, 6,e152852 .
Unraveling binding mechanism and kinetics of macrocyclic Gαq protein inhibitors
J. H. Voss; J. Nagel; M. Rafehi; R. Guixa-Gonzales; D. Malfacini; J. Patt; S. Kehraus; A. Inoue; G. M. König; E. Kostenis; X. Deupe; V. Namsivayam; C. E. Müller
Pharm. Research 2021, 173, 105880.
Local IP3 receptor–mediated Ca2+ signals compound to direct blood flow in brain capillaries
T. A. Longden; A. Mughal; G. W. Hennig; O. F. Harraz; B.o Shui; F. K. Lee; J. C. Lee; S. Reining; M. I. Kotlikoff; G. M. König; E. Kostenis; D. Hill-Eubanks; M. T. Nelson
Sci. Adv. 2021, 7, eabh0101
The chromodepsins - chemistry, biology and biosynthesis of a selective Gq inhibitor natural product family
C. Hermes; G. M. König; M. Crüsemann
Nat. Prod. Rep. 2021, 38, 2276-2292
Feature-based molecular networking for the targeted identification of Gq -inhibiting FR900359 derivatives
W. Hanke; J. Patt; J. Alenfelder; J. H. Voss; M. M. Zdouc; S. Kehraus; J. B. Kim; G. V. Grujicic; V. Namsivayam; R. Reher; C. E. Müller; E. Kostenis; M. Crüsemann; G. M. König
J. Nat. Prod. 2021, 84, 1941-1953.
An experimental strategy to probe Gq contribution to signal tansduction in living cells
J. Patt; J. Alenfelder; E. Pfeil; J. H. Voss; N. Merten; F. Eryilmaz; N. Heycke; U. Ricki; A. Inoue; S. Kehraus; X. Deupi; C. E. Mueller; G. M. Koenig; M. Cruesemann; E. Kostenis
J. Biol. Chem. 2021, 296, 100472
Biosynthesis and mechanism of action of the cell wall targeting antibiotic hypeptin. D. A. Wirtz; K. C. Ludwig; M. Arts; C. E. Marx; S. Krannich; P. Barac; S. Kehraus; M. Josten; B. Henrichfreise; A. Müller; G. M. König, A. J. Peoples; A. Nitti, A. L. Spoering; L. L. Ling; K. Lewis; M. Crüsemann; T. Schneider
Angew. Chem. Int. Ed. 2021, 133, 13691-13698.
Identification and quantification of hydroxybenzoyl and hydroxycinnamoyl derivatives from Korean sweet potato cultivars by UPLC-DAD-QTofF/MS
H.-W. Kim; S. M. Yoo; M.-N. Chung; J. B. Kim; S. Kehraus; G. M. König
J. Food Comp. Anal. 2021, 100, 103905.
In vitro characterization of 3-chloro-4-hydroxybenzoic acid building block formation in ambigol biosynthesis
I. D. M. Kresna; L. L. Ortega; T. Milzarek; E. R. Duell; M. Mir Mohseni; U. Mettal; G. M. König; T. M. Gulder; T. F. Schäberle
Org. Biom. Chem. 2021, 19, 2302-2311
Macrocyclic Gq protein inhibitors FR900359 and/or YM-254890−fit for translation?
J. G. Schlegel; M. Tahoun; A. Seidinger; J. H. Voss; M. Kuschak; S. Kehraus; M. Schneider; M. Matthey; B. K. Fleischmann; G. M. König; D. Wenzel; C. E. Müller
ACS Pharmacol. Transl. Sci. 2021, 4, 888-897
A community resource for paired genomic and metabolomic data mining
M.A. Schorn; S. Verhoeven; L. Ridder et al
Nature Chem. Biol. 2021, 17, 363-368.
Induction of antibiotic specialized metabolism by co-culturing in a collection of phyllosphere bacteria
S. Shan Qi; A. Bogdanov; M. Cnockaert; T. Acar; S. Ranty-Roby; T. Coenye; P. Vandamme; G. M. König; M. Crüsemann; A. Carlier
Environ, Microbiol 2021, 23, 2132-2151
Thioesterase-mediated side chain transesterification generates potent Gq signaling inhibitor FR900359
C. Hermes; R. Richarz; D. A. Wirtz; J. Patt; W. Hanke; S. Kehraus; J. H. Voß; J. Küppers; T. Ohbayashi; V. Namasivayam; J. Alenfelder; A. Inoue; P. Mergaert; M. Gütschow; C. E. Müller; E. Kostenis; G. M. König; M. Crüsemann
Nature Commun. 2021, 12, 144.
2020
Corallopyronin A for short-course antiwolbachial, macrofilaricidal treatment of filarial infections
A. Schiefer; M. P. Hübner; A. Krome; C. Lämmer; A. Ehrens; T. Aden; M. Koschel; H. Neufeld; L. Chaverra-MuñozI; R. Jansen; S. Kehraus; G. M. König; D. Pogorevc; R. Müller; M. Stadler; S. Hüttel; T. Hesterkamp; K. Wagner; K. Pfarr; A. Hoerauf
PLoS Negl Trop Dis 2020, 14: e0008930
Heterotrimeric G protein subunit Gaq is a master switch for Gbg-mediated calcium mobilization by Gi-coupled GPCRs
E. M. Pfeil; J. Brands; N. Merten; T. Vögtle; M. Vescovo; U. Rick; I.-M. Albrecht; N. Heycke; K. Kawakami; Y. Ono; F. M. Ngako Kadji; S. Hiratsuka; J. Aoki; F. Häberlein; M. Matthey; J. Garg; S. Hennen;; M.-L. Jobin; K. Seier; D. Calebiro; A. Pfeifer; A. Heinemann; D. Wenzel; G. M. König; B. Nieswandt; B. K. Fleischmann; A. Inoue; K. Simon; E. Kostenis.
Mol. Cell 2020, 80, 940-954.
Solubility and stability enhanced oral formulations for the anti-infective Corallopyronin A
A. K. Krome; T. Becker; S. Kehraus; A. Schiefer; C. Steinebach; T. Aden; S. J. Frohberge; Á. López Mármol; D. Kapote; Rolf Jansen; L. Chaverra-Muñoz; M. P. Hübner; K. Pfarr; T. Hesterkamp; M. Stadler; M. Gütschow; G. M. König; A. Hoerauf; K. G. Wagner
Pharmaceutics 2020, 12, 1005.
Selection of sponge-associated bacteria with high potential for the production of antibacterial compounds
Riyanti; W. Balansa; Y. Liu: A. Sharma; S. Mihajlovic; C. Hartwig; B. Leis; I. Frans; H. Wägele; G. M. König; T. F. Schäberle
Sci. Rep. 2020, 10, 19614
FFA2‑, but not FFA3‑agonists inhibit GSIS of human pseudoislets:a comparative study with mouse islets and rat INS‑1E cells
E. Lorza‑Gil; G. Kaiser; E. Rexen Ulven; G. M. König; F. Gerst; M. Barroso Oquendo; A. L. Birkenfeld; H.‑U. Häring; E. Kostenis; T. Ulven; S. Ullrich
Sci. Rep. 2020, 10, 16497.
Sensitive LC-MS/MS method for the quantification of macrocyclic Gαq protein inhibitors in biological samples
M. Kuschak; J. G. Schlegel; M. Schneider; S. Kehraus; J. H. Voss; A. Seidinger; M. Matthey; D. Wenzel; B. K. Fleischmann; G. M. König; C. E. Müller
Front. Chem. 2020, 8, 833.
Metabolome of the Phyllidiella pustulosa Species Complex (Nudibranchia, Heterobranchia, Gastropoda) Reveals Rare Dichloroimidic Sesquiterpene Derivatives from a Phylogenetically Distinct and Undescribed Clade
A. Bogdanov; A. Papu; S. Kehraus; M. Crüsemann; H. Wägele; G. M. König
J. Nat. Prod., 2020, 83, 2785-2796.
Ligand-specific allosteric coupling controls G protein-coupled receptor signaling
J. Holze; M. Bermudez; E. M. Pfeil; M. Kauk; T. Boedefeld; M. Irmen; C. Matera; C. Dallanoce; M. De Amici; U. Holzgrabe; G. M. Koenig; C. Trankle; G. Wolber; R. Schrage; K. Mohr; C. Hoffmann; E. Kostenis; A. Bock
ACS Pharmacol.Transl. Sci. 2020, 3, 859-867
Identification, Cloning, Expression and Functional Interrogation of the Biosynthetic Pathway of the Polychlorinated Triphenyls Ambigol A–C from Fischerella ambigua 108b
E. Duell; T. M. Milzarek; M. El Omari; L. J. Linares Otoya; T. F. Schäberle: G. M. König; T. A. M. Gulder
Org. Chem. Front, 2020, 7, 3193-3201.
Non-ribosomal peptides from marine-derived fungi
F. El Maddah; G. M. König; K. M. Fisch
Encyclopedia of Marine Biotechnology, 2020, https://doi.org/10.1002/9781119143802.ch103
Delineation of molecular determinants for FR900359 inhibition of Gq/11 unlocks Gαs
M. W. Boesgaard; K. Harpsoe; M. Malmberg; C. R. Underwood; A. Inoue; J. M. Mathiesen; G. M. König; E. Kostenis; D. E. Gloriam; H. Bräuner-Osborne
J. Chem. Biol., 2020, 245, 13850-1861.
From Persian Gulf to Indonesia: interrelated phylogeographic distance an chemistry within the genus Peronia (Onchidiidae, Gastropoda, Mollusca)
F. Maniei, J. Amiri Moghaddam, M. Crüsemann, C. Beemelsmann, G. M. König, H. Wägele
Sci. Rep. 2020, 10, 13048.
Gq/11-dependent regulation of endosomal cAMP generation by parathyroid hormone class B GPCR
A. D. White, F. G. Jean-Alphonse,, F. Fang, K. A. Peña, S. Liuc, G. M. König, A. Inoue, D. Aslanoglou, S. H. Gellman, E. Kostenis, K. Xiao, J.-P. Vilardaga
PNAS 2020 , 117, 7455-7460.
Antibacterial Scalarane from Doriprismatica stellata Nudibranchs (Gastropoda, Nudibranchia), Egg Ribbons, and their Dietary Sponge Spongia cf. agaricina (Demospongiae, Dictyoceratida)
C. Hertzer; S. Kehraus; N. Böhringer; F. Kaligis; R. Bara; D. Erpenbeck; T. F. Schäberle; H. Wägele; G. M. König
Beilstein J. Org. Chem. 2020, 16, 1596-1605.
Exploring Biased Agonism at FPR1 as a Means to Encode Danger Sensing
J. Gröper; G. M. König; E. Kostenis; V. Gerke; C. A. Raabe; U. Rescher
Cells 2020, 9, 1054
Halogenation-guided chemical screening provides insight into tjipanazole biosynthesis by the cyanobacterium Fischerella ambigua
T. Chilczuk; T. F. Schäberle; S. Vahdati; U. Mettal; M. El Omari; H. Enke; M. Wiese; G. M König; T. Horst; J. Niedermeyer
ChemBioChem 2020, 21, 2170-2177.
Cell-permeable high-affinity tracers for Gq proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors
M. Kuschak, V. Namasivayam, M. Rafehin, J. H. Voss, J. Garg, J. G. Schlegel, A. Abdelrahman, S. Kehraus, R. Reher, J. Küppers, K. Sylvester, S. Hinz, M. Matthey, D. Wenzel, B. K. Fleischmann, A. Pfeifer, A. Inoue, M. Gütschow, G. M. König, C. E. Müller
Br. J. Pharmacol. 2020, 177, 1898-1916
Impaired endothelium-mediated cerebrovascular reactivity promotes anxiety and respiration disorders in mice
J. Wenzel, C. E. Hansen, C. Bettonic, M. A. Vogt, B. Lembrich, R. Natsagdorja, G. Huber, J. Brands, K. Schmidt,, J. C. Assmann, I. Stölting, K. Saarf, J. Sedlacik, J. Fiehler, P. Ludewig, M. Wegmann, N. Feller, M. Richter, H. Müller-Fielitz, T. Walther, G. M. König, E. Kostenis, W. Raasch, N.t Hübner, P. Gass, S. Offermannsm, C. de Wit, C. A. Wagner, M. Schwaninger
PNAS 2020, 117, 1753-1761.
2019
5-HT2A receptor-dependent phosphorylation of mGlu2 receptor at Serine 843 promotes mGlu2 receptor-operated Gi/o signaling
S. Murat, M. Bigot, J. Chapron, G. M. König, E. Kostenis, G. Battaglia, F. Nicoletti, E. Bourinet, J. Bockaert, P. Marin, F. Vandermoere
Molecular Psychiatry 2019, 24, 1610-1626.
Structural and dynamical basis of G protein inhibition by YM-254890 and FR900359: an inhibitor in action
D. Tietze, D. Kaufmann, A. A. Tietze, A. Voll, R. Reher, G. M. König, F. Hausch
J. Chem. Inf. Model, 2019, 59, 4363-4373.
Isolation of fungi using the diffusion chamber device FIND technology
B. Libor, H. Harms, S. Kehraus, E. Egereva, M. Crüsemann, G. M. König
Beilstein J. Org. Chem. 2019,15, 2191–2203.
First survey of heterobranch sea slugs (Mollusca, Gastropoda) from the island Sangihe, North Sulawesi, Indonesia
N. I. J. Undap, A. Papu, D. Schillo, F. Gruber, F. Kaligis, M. Lepar, C. Hertzer, N. Böhringer, G. M. König, T. F. Schäberle, H. Wägele
Diversity, 2019, 11, 170.
Description of a new Moridilla species from North Sulawesi, Indonesia (Nudibranchia: Cladobranchia, Aeolidoidea) – based on MicroCT, histological and molecular analyses
D. Schillo, B. Wipfler, N. U. Undap, A. Papu, N. Böhringer, J. H. Eisenbarth, F. Kaligis, R. Bara, T. F. Schäberle, G. M. König, H. Wägele
Zootaxa, 2019, 4652, 265-295.
Activation of Gq signaling by Pasteurella multocida toxin inhibits the osteoblastogenic-like actions of activin A in C2C12 myoblasts, a cell model of fibrodysplasia ossificans progessiva
J. K. Ebner, G. M. König, E. Kostenis, P. Siegert, K. Aktories, J. H. C. Orth
'Bone, 2019, 127, 592-601
Light response of melanospin-expressing ganglion cells in the foetal mammalian retina
J. Verweij, S. Y. Chaney, D. Bredl, S. Vemaraju, G. M. König, E. Kostenis, R. A. Lang, D. R. Copenhagen
bioRxiv preprint, https://doi.org/10.1101/675702
Biased signaling of Ca2+-sensing receptors in cardiac myocytes regulates GIRK channel activity
M.-C. Kienitz, A. Niemeyer, G. M. König, E. Kostenis, L. Pott, A. Rinne
J. Mol.Cell. Card. 2019, 130, 107-121..
Complete Genome Sequence of the Corallopyronin A Producing Myxobacterium Corallococcus coralloides B035
S. Bouhired, O. Rupp, J. Blom, T. F. Schäberle, A. Schiefer, S. Kehraus, K. Pfarr, A. Goesmann, A. Hoerauf, G. M. König
Micribiol. Resour. Announc, 2019, 8, e00050-19.
Direct targeting of Gaq and Ga11 oncoproteins in cancer cells
S. Annala, X. Feng, N. Shridhar, F. Eryilmaz, J. Patt, J. H. Yang, E. M. Pfeil, R. D. Cervantes-Villagrana, A. Inoue, F. Häberlein, T. Slodczyk, R. Reher, S. Kehraus, S. Monteleone, R. Schrage, N. Heycke, U. Rick, S. Engel, A. Pfeifer, P. Kolb, G. M. König, M. Bünemann, T. Tüting, J. Vázquez-Prado, J. S. Gutkind, E. Gaffal, E. Kostenis
Sci. Signal. 2019, 12, eaau5948.
Biosynthetic studies of novel polyketides from the marine sponge-derived fungus Stachylidium sp. 293K04
F. El Maddah, E. Eguereva, S. Kehraus, G. M. König
Organic & Biomolecular Chemistry, 2019, 17, 2747-2752.
Draft Genome Sequence of the Marine Bacterium Labrenzia sp. 011, a Potential Protective Agent of Mollusks
J. A. Moghaddam, A. Dávila, M. Alanjary, J. Blom, G. M. König, T. F. Schäberle
Data, 2019, 3, 33
A platform of synthetic lethal gene interaction networks reveals that the GNAQ uveal melanoma oncogene controls the hippo pathway through FAK
X. Feng, N. Arang, D. Cosimo Rigiracciolo, J. Sang Lee, H. Yeema, Z. Wang, S. Lubrano, A. Kishore, J. A. Pachter, G. M. König, M. Maggiolini, E. Kostenis, D. D. Schlaepfer, P. Tamayo, Q. Chen, E. Ruppin, S. Gutkind
Cancer Cell. 2019, 35, p457–472.e5
Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity
D. Malfacini, J. Patt, S. Annala, K. Harpsøe, F. Eryilmaz, R. Reher, M. Crüsemann, W. Hanke, H. Zhang, D. Tietze, D. E Gloriam, H. Bräuner-Osborne, K. Strømgaard, G. M. König, A. Inoue, J. Gomeza, E.i Kostenis
J. Biol. Chem. 2019, 294, 5757-5758
Biosynthetic basis for structural diversity of aminophenylpyrrole-derived alkaloids
L. Linares-Otoya, Y. Liu, V. Linares-Otoya, L. Armas-Mantilla, M. Crüsemann, M. L. Ganoza-Yupanqui, J. Campos-Florian, G. M. König, T.l F. Schäberle
ACS Chem. Biol. 2019, 14, 176-181
Gβγ signaling to the chemotactic effector P-REX1 and mammalian cell migration is directly regulated by Gαq and Gα13 proteins
R. D. Cervantes-Villagrana, S. R. Adame-García, I. García-Jiménez, V. M. Color-Aparicio, Y. M. Beltrán-Navarro, G. M. König, E. Kostenis, G. Reyes-Cruz, S. Gutkind, J. Vázquez-Prado
J. Biol. Chem. 2019, 294, 531-546.
2018
FZD5 is a Gaq-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs
S. C. Wright, M. Consuelo Alonso Cañizal, T. Benkel, K. Simon, C. Le Gouill, P. Matricon, Y. Namkung, V. Lukasheva, G. M. König, S. A. Laporte, J. Carlsson,E. Kostenis, M. Bouvier, G. Schulte, C. Hoffmann
Sci. Signal. 2018, 11, eaar5536.
Marine Heterobranchia (Gastropoda, Mollusca) in Bunaken National Park, North Sulawesi, Indonesia—Follow-Up Diversity Study
J.-H. Eisenbarth, N. Undap, A. Papu, D. Schillo, J. Dialao, S. Reumschüssel, F. Kaligis †, R. Bara, T. F. Schäberle, G. M. König, N. Yonow, H. Wägele
Diversity 2018, 10, 127.
Comparative genomic and metabolomic analysis of marine myxobacteria reveals high potential for biosynthesis of specialized metabolites
J. A. Moghaddam, M. Crüsemann, M. Alanjary, H. Harms, A. Dávila, J. Blom, N. Ziemert, G. M. König, T. F. Schäberle
Sci. Rep. 2018, 8, 16600.
Soil bacteria isolated from tunisian arid areas show promising antimicrobial activities against Gram-negatives
Z. Nasfi, H. Busch, S. Kehraus, L. Linares-Otoya, G. M. König, T. F. Schäberle, R. Bachoual
Front. Microbiol. 2018, 9, 02742
Cyclopropane-containing fatty acids from the maine bacterium Labrenzia sp. 011 with antimicrobial and GPR84 activity
J. Amiri Moghaddam, A. Davila-Cespedes, S. Kehraus, M. Crüsemann, M. Köse, C. E. Müller, G. M. König
Marine Drugs 2018, 16, 369
RXFP1 receptor activation by relaxin-2 induces vascular relaxation in mice via a Gi2-protein/ PI3Kß/r/nitric oxide-coupled pathway
X. Lian, S. Beer- Hammer, B. Nuernberg, G. M. König, E. Kostenis, M. Gollasch
Front. Physiol. 2018. 9, 01234
Applying molecular netwoking for the detection of natural sources and analogues of the slective Gq inhibitor FR900359
R. Reher, M. Kuschak, N. Heycke, S. Annala, S. Kehraus, H.-F. Dai, C. E. Müller, E. Kostenis, G. M. König, M. Crüsemann
J. Nat. Prod., 2018, 81, 1628-1635 .
Antimicrobial Dialkylresorcins from Marine-Derived Microorganisms: Insights into Their Mode of Action and Putative Ecological Relevance
H. Harms, A. Klöckner, J. Schrör, M. Josten, S. Kehraus, M. Crüsemann, W. Hanke, T. Schneider, T. F. Schäberle, G. M. König
Planta Med. 2018, 84,.1363-1371.
Unveiling concealed functions of endosymbiotic bacteria harboured in the Ascomycota Stachylidium bicolor
C. Almeida, C. S. Pereira, V. Gonzalez-Menendez, G. Bills, J. Pascual, M. Sanchez-Hidalgo, S. Kehraus, O. Geniloud
Appl. Environ. Microbiol. 2018, 84, e00660-18 .
Deciphering specificity determinants for FR900359-derived Gαq inhibitors based on computational and structure-activity studies
R. Reher,, T. Kühl, S. Annala, T. Benkel, D. Kaufmann, B.Nubbemeyer, J. P. Odhiambo, P. Heimer, C. A. Bäuml, S. Kehraus, M, Crüsemann, E, Kostenis, D, Tietze, G. M. König, D.Imhof
ChemMedChem 2018, 13, 1634-1643.
The potential of three different PCR-related approaches for the authentication of mixtures of herbal substances and finished herbal medicinal products
K. Doganay-Knapp, A. Orland, G. M. König, W. Knöss
Phytomedicine 2018, 43, 60-67.
Draft Genome of the Marine Myxobacterial Strains Enhygromyxa salina SWB005 and SWB007
J. A. Moghaddam, A. Poehlein, H. Harms, M. Alanjari, R. Daniel, G. M. König, T. F.Schäberle
Genome Announc.. 2018, 6, e00324-18.
Draft Genome Sequence of Bacillus sp. M21, isolated from the arid area of Matmata, Tunisia
Z. Nasfi, A. Poehlein, H. Harms, E. Goralski, K. M. Fisch, R. Daniel, G. M. König, T. F.Schäberle, R. Bachoual
Genome Announc.. 2018, 6, e00323-18.
Orientia tsutsugamushi is highly susceptible to the RNA polymerase switch region inhibitor Corallopyronin A in vitro and in vivo
F. Kock, M. Hauptmann, A. Osterloh, T. F. Schäberle, S. Poppert, H. Frickmann, KD Menzel, G. Peschel, K. Pfarr, A. Schiefer, G. M. König, A. Hoerauf, B. Fleischer, C. Keller
Antimicrob Agents Chemother. 2018, 62, e01732-17.
Lack of beta-arrestin signaling in the absence of active G proteins
M. Grundmann, N. Merten, D. Malfacini, A. Inoue, P. Preis, K. Simon, N. Rüttiger, N. Ziegler, T. Benkel, N. K. Schmitt, S. Ishida, I. Müller, R. Reher, K. Kawakami, A. Inoue, U. Rick, T. Kühl, D. Imhof, J. Aoki, G. M. König, C. Hoffmann, J. Gomeza, J. Wess, E. Kostenis
Nature Commun. 2018, 9, 341
Heterologous expression, biosynthetic studies and ecological function of the selective Gq-signaling-inhibitor FR900359
M. Crüsemann, R. Reher, I. Schamari, A. O. Brachmann, T. Ohbayashi, M. Kuschak, M. Carbo-Pinto, T. Reuter, S. Kehraus, A. Hallab, T. F. Schäberle, B. Fleischmann, E. Kostenis, D. Wenzel, C. Müller, Y. Kikuchi, J. Piel, A. Carlier, L. Eberl, G. M. König
Angew. Chem. Int. Ed. 2018, 57, 836-840
The dialkyl resorcinol stemphol disrupts calcium homeostasis to trigger programmed immunogenic necrosis in cancer
S. Ji, J.-Y. Lee, J. Schrör, A. Mazumder, D. M. Jang, S. Chateauvieux, M. Schnekenburger, C. R. Hong, C. Christov, H. J. Kang, Y.o Lee, B. W. Han, K.-W. Kim, H.-Y. Shin, M. Dicato, C. Cerella, G. M. König, B. Orlikova, M. Diedrich
Canc. Lett. 2018, 416, 109-123
Bruton's tyrosine kinase and RAC1 promote cell survival in MLL-rearanged acute myeloid leukemia
S. C. Nimmagadda, S. Frey, B. Edelmann, C. Hellmich, L. Zaitseva, G. M. König, E. Kostenis, K. M. Bowles, T. Fischer
Leukemia, 2018, 32, 846-849.
Second survey of heterobranch sea slugs (Mollusca, Gastropoda, Heterobranchia) from Bunaken National Park, North Sulawesi, Indonesia - how much do we know after 12 years?
F. Kaligis, J. H. Eisenbarth, D. Schillo, J. Dialao, T. F. Schäberle, N. Böhringer, R. Bara, S. Reumschüssel, G. M. König, H. Wägele
Marine Biodiversity Records 2018, 11, 2.
2017
The Potential of Indonesian Gastropods found around Bunaken Island for Production of Bioactive Compounds
K. M. Fisch, C. Hertzer, N. Böhringer, Z. G. Wuisan, D. Schillo, R. Bara, F. Kaligis,H. Wägele, G. M. König, T. F. Schäberle
Mar. Drugs, 2017, 15, 384.
Diversity and antimicrobial potential of predatory bacteria from the peruvian coastline
L. Linares-Otoya, V. Linares-Otoya, L. Armas-Mantilla, C. Blanco-Olano, M. Crüsemann, M. L. Gonoza-Yupanqui, J. Campos-Florian, G. M. König, T. F. Schäberle. Marine Drugs, 2017, 15, 308
Identification and heterologous expression of the kocurin biosynthetic gene cluster
L. Linares-Otoya, V. Linares-Otoya, L. Armas-Mantilla, C. Blanco-Olano, M. Crüsemann, M. L. Gonoza-Yupanqui, J. Campos-Florian, G. M. König, T. F. Schäberle. Microbiologie, 2017, 163, 1409-1414
The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation. C. S. N. Klose, T. Mahlakõiv, J. B. Moeller, L. C. Rankin, A.-L. Flamar, H. Kabata, L. A. Monticelli, S. Moriyama, G. Garbès Putzel, N. Rakhilin, X. Shen, E. Kostenis, G. M. König, T. Senda, D. Carpenter, D. L. Farber, D. Artis. Nature, 2017, 549, 282-286
Targeted inhibition of Gq signaling induces airway relaxation in mouse models of asthma
M. Matthey, R. Roberts, A. Seidinger, A. Simon, R. Schröder, M. Kuschak, S. Annala, G. M. König, C. E Müller, I. P Hall, E. Kostenis, B. K. Fleischmann, D. Wenzel
Science Translational Medicine, 2017, 9, eaag2288
Reactivation of Gai-coupled formyl peptide reecptors is inhibited by Gaq-selctive inhibitors when induced by signals generated by the platelet-activating factor receptor
A. Holdfeldt, R. A. Dahlstrand, M. Gabl, Z. Rajabkhani, G. M. König, E. Kostenis, C. Dahlgren, H. Forsman
J. Leukoc. Biol. 2017, 102, 871-880
Volatiles from the fungal microbiome of the marine sponge Callyspongia cf. flammea
L. Barra, P. Barac, G. M. König, M. Crüsemann, J. S. Dickschat
Org. Biomol. Chem., 2017, 15, 7411-7421
Draft genome sequence of Zobellia sp. OII3, isolated from the coastal zone of the baltic sea
H. Harms, A. Poehlein, A. Thürmer, G. M. König, T. F. Schäberle
Genome Announc., 2017, 5, e00737-17
Biosynthetic studies on acetosellin and structure elucidation of a new acetosellin derivative
P. Hufendiek, S. S. M. Stölben, H. Harms, S. Kehraus, N. Merten, M.Crüsemann, I. Arslan, M. Gütschow, T. Schneider, G.M. König
Planta Medica, 2017, 83, 1044-1052.
Prostaglandin E2 glyceryl ester is an endogenous agonist of the nucleotide receptor P2Y6
A. Brüser, A. Zimmermann, B. C. Crews, G. Sliwoski, J. Meiler, G. M. König, E. Kostenis, V. Lede, L. M. Marnett, T. Schöneberg
Scientific Reports, 2017, 7, 2380.
Antimicrobial potential of bacteria associated with marine sea slugs from North Sulawesi, Indonesia
N. Böhringer, K. M. Fisch, D. Schillo, R. Bara, C. Hertzer, F. Grein, J.-H. Eisenbarth, F. Kaligis, T. Schneider, H. Wägele, G. M. König, T. F. Schäberle
Front. Microbiol., 2017, 8, 1092.
Secondary metabolome and its defensive role in the aeolidoidean Phyllodesmium longicirrum, (Gastropoda, Heterobranchia, Nudibranchia)
A. Bogdanov, C. Hertzer, S. Kehraus, S. Nietzer, S. Rohde, P. J. Schupp, H. Wägele, G. M. König
Beilstein J. Org. Chem., 2017, 13, 502-519
The rare amino acid building block 3-(3-furyl)-alanine in the the formation of non-ribosomal peptides
F. El Maddah, M. Nazir, G. M. König
Nat. Prod. Commun. 2017, 12, 147-150.
Phileucin - a cyclic dipeptide similar to phevalin (aureusimine B) from Streptomyces coelicolor M1146
N. Böhringer, M. Gütschow, G. M. König, T. F. Schäberle
Nat. Prod. Commun. 2017, 12, 107-109.
Production of antimicrobial compounds by fermentation
Harms H., König G.M., Schäberle T.F.
Methods in Molecular Biology, 2016, 1520, 49-61.
2016
Insights into the biosynthetic origin of 3-(3-furyl)alanine in Stachylidium sp. 293 K04 tetrapeptides
F. El Maddah, S.. Kehraus, M. Nazir, C. Almeida, G. M. König
J. Nat. Prod., 2016, 79, 2838-2845.
A novel allosteric activator of free fatty acid 2 receptor displays unique Gi-functional bias
D. Bolognini, C. E. Moss, K. Nilsson, A. U. Petersson, I. Donnelly, E. Sergeev, G. M. König, E. Kostenis, M. Kurowska-Stolarska, A. Miller, N. Dekker, A. B. Tobin, G. Milligan
J. Biol. Chem., 2016, 291, 18915-18931.
The adhesion G protein-coupled receptor GPR56/ADGRG1 is an inhibitory receptor on human NK cells
Chang, G. W., Hsiao, C. C., Peng, Y. M., Vieira Braga, F. A., Kragten, N. A., Remmerswaal, E. B., van de Garde, M. D., Straussberg, R., König, G. M., Kostenis, E., Knäuper, V., Meyaard, L., van Lier, R. A., van Gisbergen, K. P., Lin, H. H., Hamann, J.
Cell. Rep., 2016, 15, 1-15.
Marine-derived myxobacteria of the suborder Nannocystineae: An underexplored source of structurally intriguing and biologically active metabolites
A. Dávila-Céspedes, P. Hufendiek, M. Crüsemann, T. F. Schäberle, G. M. König
Beilstein J. Org. Chem., 2016, 12, 969-984.
Mapping physiological G protein-coupled receptor signaling pathways reveals a role for receptor phosphorylation in airway contraction
S.J. Bradley, C.H. Wiegman, M.M. Iglesias, K.C. Kong, A.J. Butcher, B. Plouffe, E. Goupil, J.-M. Bourggognon, T. Macedo-Hatch, C. LeGouill, K. Russell, S.A. Laporte, G.M. König, E. Kostenis, M. Bouvier, K.F. Chung, Y. Amrani, A.B. Tobin
PNAS, 2016, 113, 4524-4529.
Genome reduction and synthesis of secondary metabolites in Candidatus Burkholderia crenata, the obligate leaf nodule symbiont of Ardisia crenata Sims
A. Carlier, L. Fehr, M. Pinto, T.F. Schäberle, R. Reher, S. Dessein, G.M. König, L. Eberl
Environ. Microbiol. 2016, 18, 2507-2522.
Defensive diterpene from the Aeolidoidean Phyllodesmium longicirrum
A. Bogdanov, C. Hertzer, S. Kehraus, S. Nietzer, S. Rohde, P. J. Schupp, H. Wägele, G. M. König
J. Nat. Prod., 2016, 79, 611-615.
The Gq signalling pathway inhibits brown and beige adipose tissue
K. Klepac, A. Kilic, T. Gnad, L. M. Brown, B. Herrmann, A. Wilderman, A. Balkow, A. Glöde, K. Simon, M. E. Lidell, M. J. Betz, S. Enerbäck, J. Wess, M. Freichel, M. Blüher, G. König, E. Kostenis, P. A. Insel, A. Pfeifer
Nature Commun.,2016, 7,10895.
Endolides A and B, vasopressin and serotonin-receptor interacting N-methylated peptides from the sponge-derived fungus Stachylidium sp
C. Almeida, F. El Maddah, S. Kehraus, G. Schnakenburg, G. M. König
Org. Lett., 2016, 18, 528-531.
2015
The experimental power of FR900359 to study Gq-regulated biological processes
Ramona Schrage, Anna-Lena Schmitz, Evelyn Gaffal, Suvi Annala, Stefan Kehraus, Daniela Wenzel, Katrin M. Bullesbach, Tobias Bald, Asuka Inoue, Yuji Shinjo, Segolene Galandrin, Naveen Shridhar, Michael Hesse, Manuel Grundmann, Nicole Merten, Thomas H. Charpentier, Matthew Martz, Adrian J. Butcher, Tanja Slodczyk, Sylvain Armando, Maike Effern, Yoon Namkung, Laura Jenkins, Velten Horn, Anne Stoel, Harald Dargatz, Daniel Tietze, Diana Imhof, Celine Gales, Christel Drewke, Christa E. Muller, Michael Holzel, Graeme Milligan, Andrew B. Tobin, Jesus Gomeza, Henrik G. Dohlman, John Sondek, T. Kendall Harden, Michel Bouvier, Stephane A. Laporte, Junken Aoki, Bernd K. Fleischmann, Klaus Mohr, Gabriele M. König, Thomas Tüting, Evi Kostenis
Nature Commun., 2015, 6:10156.
Aß-42 lowering agents from the marine.derived fungus Dichotomomyces cejpii
H. Harms, S. Kehraus, D. Nesaei-Mosaferan, P. Hufendiek, L. Meijer, G. M. König
Steroids, 2015, 104, 182-188.
Harnessing enzymatic promiscuity in myxochelin biosynthesis for the production of 5-lipoxygenase inhibitors
J. Korb, S. König, S. Schieferdecker, H.M. Dahse, G.M. König, O. Werz, M. Nett
ChemBioChem, 2015, 16, 2445-2450.
Insights into structure-activity relationships of bacterial RNA polymerase inhibiting corallopyronin derivatives
T. F. Schäberle, A. Schmitz, G. Zocher, A. Schiefer, S. Kehraus, E. Neu, M. Roth, D. G. Vassylyev, T. Stehle, G. Bierbaum, A. Hörauf, K. Pfarr, G. M. König
J. Nat. Prod. , 2015, 78, 2505-2509.
GPR18 inhibiting amauromine and the novel triterpene glycoside auxarthonoside from the sponge-derived fungus Auxarthron reticulatum
M. Nazir, H. Harms, I. Loef, S. Kehraus, F. El Maddah, I.Arslan, V. Rempel, C.E. Müller, G.M. König
Planta Medica, 2015, 81, 1141-1145.
Epipolythiodiketopiperazines form the marine-derived fungus Dichotomomyces cejpij with NF-kB inhibitory potential
H. Harms, B. Orlikova, S. Ji, D. Nesaei-Mosaferan, G.M. König, M. Diederich
Marine Drugs, 2015, 13, 4949-4966
M. Nazir, F. El Maddah, S. Kehraus, E. Egereva, J. Piel, A..O. Brachmann, G.M. König
Org. Biomol. Chem., 2015, 13, 8071-8079.
New bicyclo-spartinols from the marine-derived fungus Phaeosphaeria spartinae
M. F. Elsebai, F. El Maddah, S. Kehraus, G. M. König
Nat. Prod. Com., 2015, 10, 637-639.
2014
Combining metabolomic analysis and microarray gene expression analysis in the charcterization of the medicinal plant Chelidonium majus L
A. Orland, K. Knapp, G.M. König, G. Ulrich.Merzenich, W. Knöß
Phytomedicine 2014, 21, 1587-1596.
Differential transcriptional profiles in HepG2 cells after the exposure to a chemically characterized complex preparation of Silybi mariani fructus and its chemically defined constituents silybin A + B
A. Orland, K. Knapp, G.M. König, W. Knöss, G. Ulrich-Merzenich
Synergy 2014, 1, 99-108.
Defense in the aeolidoidean genus Phyllodesmium (Gastropoda)
A. Bogdanov, S. Bleidissel, G. Preisfld, D. Schillo, J. Piel, A.O. Brachmann, H. Wägele, G.M. König
J. Chem. Ecol. 2014, 40, 1013-1024.
Function of the loading module in CorI and of the O-methyltransferase CorH in vinyl carbamate biosynthesis of the antibiotic corallopyronin A
T. F. Schäberle, M. Mir Mohseni, F. Lohr, A. Schmitz, G. M. König
Antimicrob. Agents Chemother. 2014, 58, 950-956.
Antibiotics from Myxobacteria
T. F. Schäberle, F. Lohr, A. Schmitz, G. M. König
Nat. Prod. Rep., 2014, 31, 953-972.
Enhanced production of undecylprodigiosin in Streptomyces coelicilor by co-cultivation with the corallopyronin A-producing myxobacterium Corallococcus coralloides
T. F. Schäberle, A. Orland, G. M. König
Biotech. Lett., 2014, 36, 641-648.
Indoloditerpenes from a marine.derived fungal strain of Dichotomomyces cejpii with antagonistic activity at GPR18 and cannabinoid receptors
H. Harms, V. Rempel, S. Kehraus, M. Kaiser, P. Hufendiek, C. E. Müller, G. M. König
J. Nat. Prod., 2014, 77, 673-677.
Biosynthesis of phenylnannolone A, a multidrug resistance reversal agent from the halotolerant myxobacterium Nannocystis pusilla B150
S. M Bouhired, M. Crüsemann, C. Almeida, T. Weber, J. Piel, T. F. Schäberle, G. M. König
ChemBioChem, 2014, 15, 757-765.
Identification of sequestered chloroplasts in photosynthetic and non-photosynthetic sacoglossan sea slugs (Mollusca, Gastropoda)
G. Christa, K. Händeler, T. F. Shäberle, G. M. König, H. Wägele
Frontiers in Zoology, 2014, 11, 15.
Corallorazines from the myxobacterium Corallococcus coralloide
A. Schmitz, S. Kehraus, T.F. Schäberle, E. Neu, C. Almeida, M. Roth, G. M. König
J. Nat. Prod., 2014, 77, 159-163.
Corallopyronin A – A promising antibiotic for treatment of filariasis
T.F. Schäberle, A. Schiefer, A. Schmitz, G.M. König, A. Hörauf, K. Pfarr
International Journal of Medical Microbiology, 2014, 304, 72-78.
2013
Decoding signaling and function of the orphan G protein–coupled receptor GPR17 with a small-molecule agonist
S. Hennen, H. Wang, L. Peters, N. Merten, K. Simon, A. Spinrath, S., R. Akkari, R. Schrage, R. Schröder, D. Schulz, C.Vermeiren, K. Zimmermann, S. Kehraus, C. Drewke, A. Pfeifer, G.M. König, K. Mohr, M. Gillard, C.E. Müller, Q.R. Lu, J. Gomeza, E. Kostenis
Science Signal. 2013, 6, ra93.
Double bond migration in corallopyronin A biosynthesis
F. Lohr, I. Jenniches, M. Frizler, M. J. Meehan, M. Sylvester, A. Schmitz, M. Gütschow, P. C. Dorrestein, G. M. König, T. F. Schäberle
Chem. Sci. 2013, 4, 4175-4180.
Antibiotics from gliding bacteria
A. Schmitz, S. Felder, T. Höver, S. Kehraus, E. Neu, F. Lohr, G.M. König, T.F. Schäberle
Phytochemistry Reviews, 2013, 12, 507-516.
Salimyxins and Enhygrolides: Antibiotic, sponge-related metabolites from the obligate marine myxobacterium Enhygromyxa salina
S. Felder, S. Kehraus, E. Neu, G. Bierbaum, T. F. Schäberle, G. M. König
ChemBioChem, 2013, 14, 1363-1371.
Salimabromide: Unexpected chemistry from the obligate marine myxobacterium Enhygromyxa salina
S. Felder, S. Dreisigacker, S. Kehraus, E. Neu, G. Bierbaum, P. R. Wright, D. Mneche, T. F. Schäberle, G. M. König
Chem. Eur. J., 2013, 19, 9319-9324.
Caught between triterpene- and steroid-metabolism: 4a-carboxylic pregane-derivative from the marine alga-derived fungus Phaeosphaeria spartinae
M. F. Elsebai, S. Kehraus, G. M. König
Steroids, 78, 880-883.
Unprecedented polyketides from a marine sponge-associated Stachylidium sp.
C. Almeida, E. Egereva, S. Kehraus, G. M. König
J. Nat. Prod., 2013, 76, 322-326.
What remains after 2 months of starvation? Analysis of sequestered algae in a photosynthetic slug, Plakobranchus ocellatus (Sacoglossa, Opistobranchia), by barcoding
G. Christa, L. Wescott, T. F. Schäberle, G. M. König, H. Wägele
Planta, 2013, 237, 559-572.
An easy-to-perform photometric assay for methyltransferase activity measurements
T. F. Schäberle, C. Siba, T. Höver, G. M. König
Anal. Biochem, 2013, 432, 38-40.
2012
New insight into the biosynthesis of prenylated xanthones: Xptb from Aspergillus nidulans catalsyses an O-prenylation of xanthones
D. Pockrandt, L. Ludwig, A. Fan, G. M. König, S.-M. Li
ChemBioChem, 2012, 13, 2764-2771
Polyketide skeletons from the marine alga-derived fungus Coniothyrium cereale
M. F. Elsebai, M. Nazir, S. Kehraus, E. Egereva, K. Ndjoko loset, L. Marcourt, D. Jeanerat, M. Gütschow, J.-L. Wolfender, G. M. König
Eur. J. Org. Chem, 2012, 6197-6203.
Marilines A-C: Novel phthalimidines from the sponge-derived fungus Stachylidium sp.
C. Almeida, Y. Hemberger, S. M. Schmitt, S. Bouhired, L. Natesan, S. Kehraus, K. Dimas, M. Gütschow, G. Bringmann, G. M. König
Chem. Eur. J., 2012, 18, 8827-8834.
Corallopyronin A specifically targets and depletes essential obligate Wolbachia endobacteria from filarial nematodes in vivo
A. Schiefer, A. Schmitz, T. F. Schäberle, S. Specht, C. Lämmer, K. L. Johnston, D. G. Vassylyev, G. M. König, A. Hoerauf, K. Pfarr
J. Inf. Dis., 2012, 206, 249-257.
4-Hydroxyphenylglycine biosynthesis in Herpetosiphon aurantiacus: a case of gene duplication and catalytic divergence
S. Kastner, S. Müller, L. Natesan, G. M. König, R. Guthke, M. Nett
Arch. Microbiol., 2012, 194, 557-566.
2011
Marilones A-C, phthalides from the sponge derived fungus Stachylidium sp.
C. Almeida, S. Kehraus, M. Prudencio, G. M. König
Beilstein J. Org. Chem., 2011, 7, 1636-1642.
Identifikation of a potent and selective cannabinoid CB1 receptor antagonist from Auxarthron reticulatum
M.F. Elsebai, V. Rempel, G. Schnakenburg, S. Kehraus, C.E. Müller, G.M. König
ACS. Med. Chem. Lett., 2011, 2, 866-869.
HLE-inhibitory alkaloids with a polyketide skeleton from the marine-derived fungus Coniothyrium cereale
M. F. Elsebai, L. Natesan, S. Kehraus, G. Schnakenburg, F. Sasse, S. Shaaban, M. Gütschow, G. M. König
J. Nat. Prod., 2011, 74, 2282-2285.
Dotofide, a guanidine-interrupted terpenoid from the marine slug Doto pinnatifida (Gastropoda, Nudibranchia)
A. Putz, S. Kehraus, G. Diaz-Agras, H. Wägele, G. M. König
Eur. J. Org. Chem., 2011, 3733-3737.
Stachyline A-D from the sponge derived fungus Stachylidium sp.
C. Almeida, N. Part, S. Bouhired, S. Kehraus, G. M. König
J. Nat. Prod., 2011, 74, 21-25.
Antimicrobial phenalenone derivatives from the marine-derived fungus Coniothyrium cereale
M. F. Elsebai, S. Kehraus, U. Lindequist, F. Sasse, S. Shaaban, M. Gütschow, M. Josten, H.-G. Sahl, G. M. König
Org. Biomol. Chem., 2011, 9, 802-808.
2010
Mode of action of epoxyphomalins A and B and characterization of related metabolites from the marine-derived fungus Paraconiothyrium sp.
I. E. Mohamed, S. Kehraus, A. Krick, G. M. König, G. Kelter, A. Maier, H.-H. Fiebig, M. Kalesse, N.P. Malek, H. Gross
J. Nat. Prod., 2010, 73, 2053-2056.
Fungal metabolites: structural diversity as incentive for anticancer drug development
H. Greve, I. E. Mohamed, A. Pontius, S. Kehraus, H. Gross, G. M. König
Phytochem. Rev., 2010, 9, 537-545.
Defensive strategies of Cladobranchia (Gastropoda, Opisthobranchia)
A. Putz, G. M. König, H. Wägele
Nat. Prod. Rep. , 2010, 27, 1386-1402.
Marine myxobacteria as a source of antibiotics - comparison of phylogy, polyketide-type genes and antibiotic production of three isolates of Enhygromyxa salina
T. F. Schäberle, E. Goralski, E. Neu, G. Hölzl, P. Dörmann, G. Bierbaum, Ö. Erol, G.M. König
Mar. Drugs, 2010, 8, 2466-2479.
Spartinoxide, a new enantiomer of A82775C with inhibitory activity toward HLE from the the marine-derived fungus Phaeosphaeria spartinae
M. F. Elsebai, S. Kehraus, M. Gütschow, G. M. König
Nat. Prod. Com., 2010, 5, 1071-1076.
Synergistic allelochemicals from a freshwater cyanobacterium
P.N. Lao, A.R. Pereira, W.-T. Liu, J. Ng, P.A. Pevzner, P.C. Dorrestein, G.M. König, V.M. Vasconcelos, W.H. Gerwick
PNAS, 2010, 107, 11183-11188.
Biosynthesis of the myxobacterial antibiotic Corallopyronin A
Ö. Erol, T. F. Schäberle, A. Schmitz, S. Rachid, C. Gurgui, M. El Omari, F. Lohr, S. Kehraus, J. Piel, R. Müller, G. M. König
ChemBioChem, 2010, 11, 1253-12665.
Novel bisabolane sesquiterpenes from the marine-derived fungus Verticilium tenerum
C. Almeida, S. Elsaedi, S. Kehraus, G. M. König
Nat. Prod. Com., 2010, 5, 507-510.
Hydroxylated sclerosporin derivatives from the marine-derived fungus Cadophora malorum
C. Almeida, E. Eguereva, S. Kehraus, C. Siering, G. M. König
J. Nat. Prod., 2010, 73, 476-478.
In vitro chemopreventive potential of fucophlorethols from the brown alga Fucus vesiculosus L. by anti-oxidant activity and inhibition of selected cytochrome P450 enzymes
S. Parys, S. Kehraus, A. Krick, K.-W. Glombitza, S. Carmeli, K. Klimo, C. Gerhäuser, G. M. König
Phytochemistry, 2010, 71, 221-229.
2009
New Polyketides from the marine-derived fungus Phaeosphaeria spartinae
M.F. Elsebai, S. Kehraus, M. Gütschow, G. M. König
Nat. Prod. Com., 2009, 4, 1463-1468.
Epoxyphomalin A and B, prenylated polyketides with potent cytotxicity from the marine-derived fungus Phoma sp.
Org. Lett., 2009, 11, 5014-5017.
Inhibition of human leukocyte elastase by brunsvicamides A-C: Cyanobacterial cyclic peptides
M. T. Sisay, S. Hautmann, C. Mehner, G. M. König, J. Bajorath, M. Gütschow
ChemMedChem, 2009, 4, 1425-1429.
Seasonal variation of polyphenolics in Ascophyllum nodosum (Phaeophyceae)
S. Parys, S. Kehraus, R. Pete, F. C. Küpper, K.-W. Glombitza, G. M. König
Europ. J. Phycol., 2009, 44, 331-338.
The superhydrophilic and superoleophilic leaf surface of Ruellia devosiana (Acanthaceae): a biological model for spreading of water and oil on surfaces
K. Koch, I. C. Blecher, G. M. König, S. Kehraus, W. Barthlott
Funct. Plant. Biol., 2009, 36, 339-350.
Biohalogenation: Nature's way to synthesize halogenated metabolites
C. Wagner, M. El-Omari, G. M. König
J. Nat. Prod., 2009, 72, 540-553.
Three new spongian diterpenes from the Fijian marine sponge Spongia sp.
H. Gross, A. D. Wright, U. Reinscheid, G. M. König
Nat. Prod. Com., 2009, 4, 315-322.
Cytotoxic and HLE-inhibitory tetramic acid derivatives from marine derived fungi
K. Neumann, S. Kehraus, M. Gütschow, G. M. König
Nat. Prod. Com., 2009, 4, 347-354.
Dietary derived sesquiterpenes from Phyllodesmium lizardensis
S. Affeld, S. Kehraus, H. Wägele, G. M. König
J. Nat. Prod., 2009, 72, 298-300.
Myxotyrosides A and B, unusual rhamnosides from Myxococcus sp.
B. Ohlendorf, W. Lorenzen, S. Kehraus, A. Krick, H. B. Bode, G. M. König
J. Nat. Prod., 2009, 72, 82-86.
2008
Phenylnannolones A-C: Biosynthesis of new secondary metabolites from the myxobacterium Nannocystis exedens
B. Ohlendorf, S. Leyers, A. Krick, S. Kehraus, M. Wiese, G. M. König
ChemBioChem, 2008, 9, 2997-3003.
New peptolides from the cyanobacterium Nostoc insulare as selective and potent inhibitors of human leukocyte elastase
C. Mehner, D. Müller, S. Kehraus, S. Hautmann, M. Gütschow, G. M. König
ChemBioChem, 2008, 9, 2692-2703.
Monodictyochromes A and B, dimeric xanthone derivatives from the marine algicolous fungus Monodyctis putredinis
A. Pontius, A. Krick, R. Mesry, S. Kehraus, S. E. Foegen, M. Müller, K. Klimo, C. Gerhäuser, G. M. König
J. Nat. Prod., 2008, 71, 1793-1799.
Noduliprevenone: A novel heterodimeric chromanone with cancer chemopreventive potential
A. Pontius, A. Krick, S. Kehraus, S. E. Foegen, M. Müller, K. Klimo, C. Gerhäuser, G. M. König
Chem. Eur. J., 2008, 32, 9860-9863.
Myxochromide B3, a new member of the myxochromide family of secondary metabolites
B. Ohlendorf, S. Kehraus, G. M. König
J. Nat. Prod., 2008, 71, 1708-1713.
Apralactone A and a new stereochemical class of curvularins from the marine fungus Curvularia sp.
H. Greve, P. J. Schupp, E. Eguereva, S. Kehraus, G. Kelter, A. Maier, H.-F. Fiebig, G. M. König
Eur. J. Org. Chem, 2008, 5085-5092.
Antiprotozoal activities of heterocyclic-substituted xanthones from the marine-derived fungus Chaetomium sp.
A. Pontius, A. Krick, S. Kehraus, R. Brun, G. M. König
J. Nat. Prod., 2008, 71, 1579-1584.
Ten membered lactones from the marine-derived fungus Curvularia sp.
H. Greve, P. J. Schupp, E. Eguereva, G. M. König
J. Nat. Prod., 2008, 71, 1651-1653.
A novel beta-amino acid in cytotoxic peptides from the cyanobacterium Tychonema sp.
C. Mehner, D. Müller, A. Krick, S. Kehraus, R. Löser, M. Gütschow, A. Maier, H.-F. Fiebig, R. Brun, G. M. König
Eur. J. Org. Chem, 2008, 1732-1739.
Das Potenzial PCR-basierter Markermethoden zur Identifizierung von Arzneipflanzen
T. Kersten, C. Daniel, G. M. König, W. Knöß
Zeitschrift für Phytotherapie, 2008, 29, 122-128.
Cytotoxic bastadin 24 from the australian sponge Ianthella quadrangulata
H. Greve, S. Kehraus, A. Krick, G. Kelter, A. Maier, H.-F. Fiebig, A. D. Wright, G. M. König
J. Nat. Prod., 2008, 71, 309-312.
Aromatic polyketides from marine algicolous fungi
A. Pontius, I. Mohamed, A. Krick, S. Kehraus, G. M. König
J. Nat. Prod., 2008, 71, 272-274.
Critical view on the monochlorodimedone assay utilized to detect haloperoxidas activity
C. Wagner, I. M. Molitor, G. M. König
Phytochemistry, 2008, 69, 323-332.
2007
Evaluation of quantitative methods for the determination of polyphenols in algal extracts
S. Parys, A. Rosenbaum, S. Kehraus, G. Reher, K.-W. Glombitza, G. M. König
J. Nat. Prod., 2007, 70, 1865-1870.
The chemistry of gliding bacteria
M. Nett, G. M. König
Nat. Prod. Rep. , 2007, 24, 1245-1261.
New Iantherans from the Marine Sponge Ianthella quadrangulata : Novel Agonists of th P2Y11 Receptor
H. Greve, S. Meis, M. U. Kassack, S. Kehraus, A. Krick, A. D. Wright, G. M. König
J. Med. Chem. , 2007, 50, 5600-5607.
Trichothecenes induce accumulation of glycosylceramide in neural cells by interfering with lactosylceramide synthase activity
A. Kralj, M. Gurgui, G. M. König, G. van Echtem-Deckert
Toxicology and Applied Pharmacology, 2007, 225, 113-122.
A marine Mesorhizobium sp. produces structurally novel long-chain N-acyl-L-homoserine lactones
A. Krick, S. Kehraus, L. Eberl, K. Riedel, H. Anke, I. Kaesler, I. Graeber, U. Szewzyk, G. M. König
Appl. Environ. Microbiol. , 2007, 73, 3587-3594.
Two new depsipeptides from the marine fungus Spicellum roseum
A. Kralj, S. Kehraus, A. Krick, G. van Echten-Deckert, G. M. König
Planta Medica , 2007, 73, 366-371.
Novel sorbicillin derivatives with an unprecedented carbon skeleton from the sponge-derived fungus Trichoderma species
K. Neumann, A. Abdel-Lateff, A. D. Wright, S. Kehraus, A. Krick, G. M. König
Eur. J. Org. Chem. , 2007, 2268-2275.
Potential cancer chemopreventive in vitro activities of monomeric xanthone derivatives from the marine algicolous fungus Monodictys putredinis
A. Krick, S. Kehraus, C. Gerhäuser, K. Klimo, M. Nieger, A. Maier, H.-F. Fiebig, I. Atodiresei, G. Raabe, J. Fleischhauer, G. M. König
J. Nat. Prod. , 2007, 70, 353-360.
Ascospiroketals A and B, unprecedented cycloethers from the marine-derived fungus Ascochyta salicorniae
S. F. Seibert, A. Krick, E. Eguereva, S. Kehraus, G. M. König
Org. Lett. , 2007, 9, 239-242.
2006
Natural products from marine organisms and their associated microbes
G. M. König, S. Kehraus, S. F. Seibert, A. Abdel-Lateff, D. Müller
ChemBioChem , 2006, 7, 229-238.
Siphonazol, an unusual metabolite from Herpetosiphon sp.
M. Nett, Ö. Erol, S. Kehraus, M. Köck, A. Krick, E. Eguereva, E. Neu, G.M. König
Angew. Chem. Int. , 2006, 23, 3863-3867.
Brunsvicamides A-C: Sponge related cyanobacterial peptides with Mycobacterium tuberculosis protein tyrosine phosphatase activity
D. Müller, A. Krick, S. Kehraus, C. Mehner, M. Hart, F.C. Küpper, K. Saxena, H. Prinz, H. Schwalbe, P. Janning, H. Waldmann, G.M. König
J. Med. Chem., 2006, 49, 4871-4878
Poleketides from marine-derived fungus Ascochyta salicorniae and their potential to inhibit protein phophatases
S.F. Seibert, E. Eguereva, A. Krick, S. Kehraus, E. Voloshina, G. Raabe, J. Fleischhauer, E. Leistner, M. Wiese, H. Prinz, K. Alexandrov, P. Janning, H. Waldmann, G.M. König
Org. Biomol. Chem., 2006, 4, 2233-2240.
An attempt to determine the absolute configuration of two ascolactone stereoisomers with time-dependent density functional theory
S.F. Seibert, G.M. König, E. Voloshina, G. Raabe, J. Fleischhauer
Chirality, 2006, 18, 413-418.
Terpenoids from marine organisms: unique structures and their pharmacological potential
H. Gross, G.M. König
Phytochemistry Reviews, 2006, 5, 115-141.
Arugosins G and H: Prenylated polyketides from the marine-derived fungus Emericella nidulans var. acristata
A. Kralj, S. Kehraus, A. Krick, E. Eguereva, G. Kelter, M. Maurer, A. Wortmann, H.-H. Fiebig, G.M. König
J. Nat. Prod., 2006, 69, 995-1000.
Antioxidant activity of 3,4,5-trihydroxybenzaldehyde isolated from Geum japonicum
J.B. Kim, G.M. König, A.D. Wright
J. Food Drug Anal., 2006, 14, 190-193
Effects of cyanobacterium Fischerella ambigua isolates and cell free culture media on zebra fish (Danio rerio) embryo development
A.D. Wright, O. Papendorf, G.M. König, A. Oberemm
Chemosphere, 2006, 65, 604-608.
2005
Potentiation of human α4β2 neuronal nicotinic receptors by a Flustra foliacea metabolite
F. Sala, J. Mulet, K.P. Reddy, J.A. Bernal, P. Wikman, L.M. Valor, L.Peters, G.M. König, M. Criado, S. Sala
Neurosc. Lett. 2005, 373, 144-149.
Stereochemical Heterogenity in Verongid Sponge Metabolites. Absolute Stereochemistry of (+)-Fistularin-3 and (+)-11-epi-Fistularin-3 by Microscale LCMS-Marfey’s Analysis
E.W. Rogers, M.F. de Oliveira, R.G.S. Berlinck, G.M. König, T.F. Molinski
J. Nat. Prod., 2005, 68, 891-896.
Ambigol C and 2,4-Dichlorbenzoic Acid, Natural Products Produced by the Terrestrial Cyanobacterium Fischerella ambigua
A.D. Wright, O. Papendorf, G.M. König
J. Nat. Prod. 2005, 68, 459-461.
2004
Prenylated Indole Alkaloids from Flustra foliacea with Subtype Specific Binding on NAChRs
L.Peters, A.D. Wright, St. Kehraus, D. Gündisch, M. C. Tilotta, G. M. König
Planta Med., issue dedicated to Prof. Nahrstedt, 2004, 70, 883-886
Isolation and structure elucidation of azoricasterol, a new sterol of the deep water sponge Macandrewia azorica
H. Gross, J. Reitner, G.M. König
Naturwissenschaften, 2004, 91, 441-446.
Novel Amino Acid Derived Natural Products from the Ascidian Atriolum robustum: Identification and pharmacological characterization of a unique adenosine derivative
S. Kehraus, S. Gorzalka, C. Hallmen, J. Igbal, Ch.E. Müller, A.D. Wright, M. Wiese, G.M. König
J. Med. Chem., 2004, 47, 2243-2255.
Translation initiation factor eIF-5A from Plasmodium falciparum
I.M.Molitor, S. Knöbel, Ch. Dang, T. Spielmann, A. Alléra, G.M. König
Mol. Biochem. Parasitol., 2004, 137, 65-74.
New Secondary Metabolites from the Marine Endophytic Fungus Apiospora montagnei
Ch. Klemke, S. Kehraus, A.D. Wright and G.M. König
J. Nat. Prod., 2004, 67, 1058-1063.
Variation of Brominated Indoles and Terpenoids within single and different colonies of the Marine Bryozoan Flustra foliaceae
L. Peters, A.D. Wright, A. Krick and G.M. König
J. Chem. Ecol., 2004, 30, 1165-1181.
Two new bicyclic cembranolides from a new Sarcophyton species and determination of the absolute configuration of sarcoglaucol-16-one
H. Gross, A.D. Wright, W. Beil, and G.M. König
Org. Biomol. Chem., 2004, 2, 1133-1138.
2003
Epicoccamide, a Novel Secondary Metabolite from a Jellyfish-Derived Culture of Epicoccum purpurascens
A.D. Wright, C. Osterhage, G. M. König
Org Biomol Chem, 2003, 1, 507-510.
Oxygenated Analogues of Gorgesterol and Ergosterol from the Soft Coral Capnella lacertiliensis
E. Goclik, G. M. König, A. D. Wright
J. Nat. Prod., 2003, 66, 157-160.
New Cytotoxic cembrane based diterpenes from the soft corals Sarcophyton cherbonnieri and Nephthea sp.
Groß, H., Kehraus, S., Nett, M., König, G. M., Beil, W., Wright, A. D.
Org. Biomol. Chem., 2003, 1, 944-949.
Three New Sesquiterpenes from the Red Alga Laurencia perforata
A. D. Wright, E. Goclik, G. M. König
J. Nat. Prod., 2003, 66, 435-437.
Responses of marine macroalgae to hydrogen-peroxide stress
A.L. Dummermuth, U. Karsten, K. M. Fisch, G. M. König, C. Wiencke
J. Exp. Mar. Biol. Ecol., 2003, 289, 103-121.
Two New Xanthone Derivatives from the Algicolous Marine Fungus Wardomyces anomalus
A. Abdel-Lateff, Ch.Klemke, G. M. König, A. D. Wright
J. Nat. Prod., 2003, 66 , 706-708.
Secondary Metabolites of Flustra foliacea and their influence on bacteria
L. Peters. G. M. König, A. D. Wright, R. Pukall, E. Stackebrandt, L. Eberl, K. Riedel
Appl. Environ. Microbiol., 2003, 69, 3469-3475
Antioxidative Meroterpenoids from the Brown Alga Cystoseira crinita
Katja M. Fisch, Volker Böhm, Anthony D. Wright, Gabriele M. König
J. Nat. Prod., 2003, 66, 968-975
HPLC Isolation of the Antiplasmodially Active Bisbenzylisoquinoline Alkaloids in Cissampelos mucronata Roots
J. Ndaya Tshibangu, A. D. Wright, G. M. König
Phytochem. Anal. 2003, 14 , 13-22
A New Antioxidant Isobenzofuranone Derivative from the Algicolous Marine Fungus Epicoccum sp.
Ahmed Abdel-Lateff, Katja M. Fisch, Anthony D. Wright, Gabriele M. König
Planta Med., 2003, 69, 831-834.
2002
A New Cytotoxic Calyculinamide Derivative, Geometricin A, from the Australian Sponge Luffariella geometrica
S. Kehraus, G. M. König, A.D. Wright
J. Nat. Prod. 2002, 65, 1056-1058.
Leucamide A: A New Cytotoxic Heptapeptide from the Australian Sponge Leucetta microraphis
S. Kehraus, G. M. König, A. D. Wright
J. Org. Chem., 2002, 67, 4989-4992.
Evaluation of selected Sudanese medicinal plants for their in vitro activity against hemoflagellates, selected bacteria, HIV-1-RT and tyrosine kinase inhibitory, and for cytotoxicity
H. Ali, G.M. König, S.A. Khalid, A.D. Wright, R. Kaminsky
J. Ethnopharmacol., 2002, 83, 219-228
5-Hydroxyramulosin, a New Natural Product Produced by Phoma tropica, a Marine-Derived Fungus from the Alga Fucus spiralis
C. Osterhage, G. M. König, P. G. Jones, A. D. Wright
Planta Med. 2002, 68, 1052-1054.
Rare Sesquiterpenes from the Algicolous Fungus Drechslera dematioidea
C. Osterhage, G. M. König, U. Höller, A. D. Wright
J. Nat. Prod. 2002, 65, 306-313.
Lepadins D-F: Antiplasmodial and Antitrypanosomal Decahydroquinoline Derivatives from the Tropical Marine Tunicate Didemnum sp.
A. D. Wright, E. Goclik, G. M. König, R. Kaminsky
J. Med. Chem. 2002, 45, 3067-3072.
Screening of African Medicinal Plants for Antimicrobial and Enzyme Inhibitory Activity
J. Ndaya Tshibangu, K. Chifundera, R. Kaminsky, A. D. Wright, G. M. König
J. Ethnopharmacol., 2002, 80, 25-35.
New Antioxidant Hydroquinone Derivatives from the Algicolous Marine Fungus Acremonium sp.
A. Abdel-Lateff, G. M. König, K. M. Fisch, U. Höller, P. Jones, A. D. Wright
J. Nat. Prod., 2002, 65, 1605-1611.
Four New Bromo-tryptamine Derivatives from the Marine Bryozoan Flustra foliacea
L. Peters, G. M. König, H. Terlau, A. D. Wright
J. Nat. Prod., 2002, 65, 1633-1637.
New and Biologically Active Imidazole Alkaloids from two Sponges of the Genus Leucetta
H. Gross, S. Kehraus, G. M. König, G. Wörheide, A. D. Wright
J. Nat. Prod. 2002, 65, 1190-1193.
2001
New Carbonimidic Dichlorides from the Australian sponge Ulosa spongia and their possible taxonomic significance
S. Kehraus, G. M. König and A. D. Wright
J. Nat. Prod., 2001, 64, 939-941.
3-Acetoxyspathulenol, a New Aromadendrane-Type Natural Product from the Soft Coral Parerythropodium fulvum
M. Wessels, G. M. König, A. D. Wright
J. Nat. Prod. 2001, 64, 370-372.
Inhibition of Heme Detoxification Processes underlies the Antimalarial Activity of Terpene Isonitrile Compounds from Marine Sponges
A. D. Wright, H. Wang, M. Gurrath, G. M. König, G. Kocak, G. Neumann, P. Loria, M. Foley, L. Tilley
J. Med. Chem., 2001, 44, 873-885.
New 4-Methoxybenzoyl Derivatives from the Ascidian Polycarpa aurata
M. Wessels, G. M. König, A. D. Wright
J. Nat. Prod. 2001, 64, 1556-1558.
2000
A New Bioactive Sesterterpene and Antiplasmodial Alkaloids from the Marine Sponge Hyrtios cf. erecta
Gesa Kirsch, A. D. Wright, G. M. König
J. Nat. Prod., 2000, 63, 825-829.
New Natural Product Isolation and Comparison of the Secondary Metabolite Content of Three Distinct Samples of the Sea Hare Aplysia dactylomela from Tenerife
M. Wessels, G. M. König and A. D. Wright
J. Nat. Prod., 2000, 63, 920-928.
Assessment of Antimycobacterial Activity of a Series of Mainly Marine Derived Natural Products
G. M. König, A. D. Wright and S. G. Franzblau
Planta Med., 2000, 66, 337-342.
Fungi from Marine Sponges: Diversity Biological Activity and Secondary Metabolites
U. Höller, A. D. Wright, G. F. Matthée, G. M. Konig, S.Draeger, H-. J. Aust, B. Schulz
Mycol. Res., 2000, 104, 1354-1365.
Pelorol from the Tropical Marine Sponge Dactylospongia elegans
E. Goclik, G. M. König and A. D. Wright
J. Nat. Prod., 2000, 63, 1150-1152.
HPLC-DAD and HPLC-MS Investigations of Marine and Terrestrial Phoma Species
C. Wegner, M. Schwibbe, G. M. König and A. D. Wright
Phytochem. Anal., 2000, 11, 288-294.
Ascosalipyrrolidinone A, an Antimicrobial Alkaloid, from the Obligate Marine Fungus Ascochyta salicorniae
C. Wegner, R. Kaminsky, G. M. König, and A. D. Wright
J. Org. Chem., 2000, 65, 6412-6417.
Fungi from marine sponges: diversity, biological activity and secondary metabolites
U. Höller, A. D. Wright, G. F. Matthée, G. M. König, S. Draeger, H.-J. Aust and B. Schulz
Mycol. Res., 2000, 104, 1354-1365.
NMR Spektroskopie, G. M. König, A. D. Wright, in: Analytik biogener Arzneistoffe, Pharmazeutische Biologie, Band 4, H. Becker, K. Adam (eds.)
Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, 2000, 37-55.
1999
Geniculol, A New Biologically Active Diterpene from the Endophytic Fungus Geniculosporium sp.
G. M. König, A. D. Wright, S. Draeger, H. -J. Aust, B. Schultz
J. Nat. Prod., 1999, 62, 155-157.
Three New Metabolites from Marine Derived Fungi of the Genera Coniothyrium and Microsphaeropsis
U. Höller, G. M. König, A. D. Wright
J. Nat. Prod., 1999, 62, 114-118.
Three New Scalarane Based Sesterterpenes from the Tropical Marine Sponge Strepsichordaia lendenfeldi
T. Jahn, G. M. König, A. D. Wright
J. Nat. Prod., 1999, 62, 375-377.
Halogenated Monoterpenes from Plocamium costatum and their Biological Activity
G. M. König, A. D. Wright and R. de Nys
J. Nat. Prod., 1999, 62, 383-385.
A New Tyrosine Kinase Inhibitor from the Marine Brown Alga Stypopodium zonale
M. Wessels, G. M. König and A. D. Wright
J. Nat. Prod.,1999, 62, 927-930.
Colletoketol
U. Höller, A. D. Wright, G. M. König, P. G. Jones
Acta Cryst., 1999, C55, 1310-1313.
1H and 13C NMR and Biological Activity Investigations of four LIchen Derived Compounds
G. M. König and A. D. Wright
Phytochem. Anal., 1999, 10, 279-284.
Cymbastela hooperi and Amphimedon terpenensis: Where do they really belong?
G. M. König and A. D. Wright
Mem. Qd. Mus., 1999 (30 June), 44, 281-288.
Hydrophilic Metabolites from the Tropical Marine Sponge Carteriospongia sp.
G. M. König and A. D. Wright
Planta Med., 1999, 65, 679-680.
Plocamium hamatum and Its Monoterpenes: Chemical and Biological Investigations of the Tropical Marine Red Alga
G. M. König, A. D. Wright and A. Linden
Phytochemistry, 1999, 52, 1047-1053.
A New Tyrosine Kinase Inhibitor from a Marine Isolate of Ulocladium botrytis and New Metabolites from the Marine Fungus Asteromyces cruciatus and Varicosporina ramulosa
U. Höller, G. M. König, A. D. Wright
Euro. J. Org. Chem., 1999, 2949-2955.
Collection and Secondary Metabolite Investigations of Marine Organisms from the two Azorean Islands Faial and St. Jorge
E. Goclik, G. M. König and A. D. Wright
Arquipelago, Bulletin of the University of the Azores, Life and Marine Sciences, 1999, 17A, 43-49.
HIV Reverse Transcriptase Inhibitors of Natural Origin
G. Mattee, G. M. König, A. D. Wright
Planta Med., 1999, 65, 493-506.
Trends in Marine Biotechnology
G. M. König, A. D. Wright
in: Drug Discovery in Nature, Grabley, Thiericke (eds.), Springer Verlag, ISBN 64844-5, 1999, 180-187.
1998
An Unprecedented Compound from the Dichloromethane Solubles of the Tropical Marine Sponge Agelas oroides
G. M. König, A. D. Wright
Planta Med., 1998, 64, 88-89.
Three New Diterpenes from the Marine Soft Coral Lobophytum crassum
G. Matthée, G. M. König and A. D. Wright
J. Nat. Prod., 1998, 61, 237-240.
New Cembranoid Diterpenes from the Soft Coral Sarcophyton ehrenbergi
G. M. König and A. D. Wright
J. Nat. Prod., 1998, 61, 494-496.
Antiplasmodial and Cytotoxic Metabolites from the Maltese Sponge Agelas oroides
G. M. König, A. D. Wright and A. Linden
Planta Med., 1998, 64, 443-447.
Hypoglycemic Activity of a HMG-Containing Flavonoid Glucoside from Chamaemelum nobile
G. M. König, A. D. Wright, W. J. Keller, R. L. Judd, and C. Day
Planta Med., 1998, 64, 612-614.
Heirridin B and 2,4-Dimethoxy-6-heptadecyl-phenol, Secondary Metabolites from the Cyanobaterium Phormidium ectocarpi with Antiplasmodial Activity
O. Papendorf, G. M. König, A. D. Wright
Phytochemistry, 1998, 49, 2383-2386.
Sesquiterpene Content of the Antibacterial Dichloromethane Extract of the Marine Red Alga Laurencia obtusa
G. M. König and A. D. Wright
Planta Med., 1997, 63, 186-187.
Secondary Metabolite Investigation of the "Living Fossil" Sponge Astrosclera willeyana
T. Jahn, G. M. König, A. D. Wright, G. Wörheide, J. Reitner
Tetrahedron Lett., 1997, 38, 3883-3884.
Ressource der Zukunft: Wirkstoffe aus marinen Organismen
G. M. König, A. D. Wright
Pharmazeutische Zeitung, 1998, 143, 4153.
1997
New and Unusual Sesquiterpenes; Kelsoene, Prespatane, Epi-g-Gurjunene and T-Cadinthiol, from the Tropical Marine Sponge Cymbastela hooperi
G. M. König, A. D. Wright
J. Org. Chem., 1997, 62, 3837-3840.
Pulsed Field Gradient Spectroscopy (PFGS): Application to the Structure Elucidation of (+)-(10S)-10-Bromo-beta-Chamigrene
G. M. König and A. D. Wright
Phytochem. Anal., 1997, 8, 167-172.
Two New Sesterterpene Tetronic Acids from the Marine Sponge Ircinia oros
U. Höller, G. M. König, A. D. Wright
J. Nat. Prod., 1997, 60, 832-835.
Laurencia rigida: Chemical Investigations of its Antifouling Dichloromethane Extract
G. M. König, A. D. Wright
J. Nat. Prod., 1997, 60, 967-970.
Marine and Aquatic Environments: Souces of Novel and Biologically Active Secondary Metabolites
G. M. König and A. D. Wright
Chemica Chronica (General edition), 1997, 59, 106-107.
Mueggelone, a Novel Inhibitor of Fish Development from the Fresh Water Cyanobacterium Aphanizomenon flos aquae
O. Papendorf, G. M. König, A. D. Wright, I. Chorus, A. Oberemm
J. Nat. Prod., 1997, 60, 1298-1300.
Meeresorganismen als Produzenten pharmakologisch aktiver Stoffe
G. M. König, A. D. Wright
Pharmazie in unserer Zeit, 1997, Heft 6, 26. Jahrg., 281.
The Marine Environment: A Source of Novel Antimalarial Lead Structures
G. M. König, A. D. Wright
in: Virtual Activity, Real Pharmacology Different Approaches to the Search for Bioactive Natural Compounds, L. Verotta (ed), Research Signpost, Trivandrum, 1997, 159.
1996
Chamaemeloside, a New Flavonoid Glycoside from Chamaemelum anthemis
G. A. Tschan, G. M. König, A. D. Wright and O. Sticher
Phytochemistry, 1996, 41, 643-646.
Novel Potent Antimalarial Diterpene Isocyanates, Isothicyanates, and Isonitriles from the Tropical Marine Sponge Cymbastela hooperi
G. M. König, A. D. Wright, C. K. Angerhofer
J. Org. Chem., 1996, 61, 3259-3267.
Antimalarial Activity: The Search for Marine Derived Natural Products which Demonstrate Selective Antimalarial Activity
A. D. Wright, G. M. König, C. K. Angerhofer, P. Greenidge, A. Linden and R. Desqueyroux-Faundez
J. Nat. Prod., 1996, 59, 710-716.
Cymbastela hooperi n. sp. (Halichondria, Axinellidae) from the Great Barrier Reef, Australia
R. W. M. van Soest, R. Desqueyroux-Faundez, A. D. Wright, G. M. König
Bulletin of the Royal Belgian Institute for Natural Sciences, Biologie, 1996, 66 suppl., 103.
X-Ray Crystal Structure of Amphilectane Derivatives
A. Linden, G. M. König and A. D. Wright
Acta Cryst., 1996, C52, 2601-2607.
Cymbastella hooperi sp. nov. (Halichondrida:Axinellidae) from the Great Barrier Reef, Australia
R. W. M. Van Soest, R. Desqueyroux-Faundez, A. D. Wright and G. M. König
Bull. Inst. R. Sci. Nat. Belg., 1996, 66 suppl., 103-108.
Marine Natural Products Research: Current Directions and Future Potential
G. M. König, A. D. Wright
Planta Med., 1996, 62, 193-211.
1995
Two New Naturally Occurring Pyrrole Derivatives from the Tropical Marine Sponge Agelas oroides
G. M. König and A. D. Wright
Nat. Prod. Lett., 1995, 5, 141.
Concerted Application of a Shift Reagent and 2D NOESY to the Structure Determination of New Natural Products from the Tropical Brown Alga Dictyopteris delicatula
G. M. König and A. D. Wright
Magn. Reson. Chem., 1995, 33, 178-183.
Biological Activities of Cyanobacteria: Evaluation of Extracts and Pure Compounds
B. Falch, G. M. König, A. D. Wright, O. Sticher, H. Bachmann, C. K. Angerhofer and J. M. Pezzuto
Planta Med.,1995, 61, 321-328.
Chemical aspects of mass spawning in corals. II.(-)-Epi-thunbergol, the sperm attractant in the eggs of the soft coral Lobophytum crassum (Cnidaria : Octocorallia)
J. C. Coll, P. A. Leone, B. F. Bowden, A. R. Carroll, G. M. König, A. Heaton, R. de Nys, M. Maida, P. M. Alino, R. H. Willis, R. C. Babcock, Z. Florian, M. N. Clayton, R. L. Miller, P. N. Alderslade
Mar. Biol., 1995, 123, 137-143.
1H (300MHz) and 13C NMR spectral assignments for diisocyanoadociane
G. M. König, A. D. Wright
Magn. Reson. Chem., 1995, 33, 694-697.
N,N-Dimethyl-1H-pyrrole-2-carboxamide
A. D. Linden, A. D. Wright, G. M. König
Acta Cryst., 1995, C51, 744-747.
Determination of the Absolute Configuration of a Series of Halogenated Furanones from the Marine Red Alga Delisea pulchra
G. M. König, A. D. Wright and G. Bernardinelli
Helv. Chim. Acta, 1995, 78, 758-764.
Studies on the Glycolipid Content of the Cyanobacterium Fischerella ambigua
B. Falch, G. M. König, A. D. Wright, O. Sticher
Planta Med.,1995, 61, 540-543.
1994
X-Ray Structure of 3,4-Epoxypalisadin A
G. M. König, A. D. Wright, F. Fronczek
J. Nat. Prod., 1994, 54, 151-154.
Diterpenes from the Brown Alga Dilophus Mediterraneus
C. Goez, A. D. Wright, G. M. König and O. Sticher
Phytochem. Analysis, 1994, 5, 68-73.
Chemical aspects of mass spawning in corals. I. Sperm-attractant molecules in the eggs of the scleractinian coral Montipora digitata
J. C. Coll, B. F. Bowden, G. V. Meehan, G. M. König, A. R. Carroll, D. M. Tapiolas, P. M. Alino, A. Heaton, R. De Nys, P. A. Leone, M. Maida, T. L. Acetet, R. H. Willis, R. C. Babcock, B. L. Willis, Z. Florian, M. N. Clayton, R. L. Miller
Mar. Biol., 1994, 118, 177-182.
Revised Structure of a Brasilane-Type Sesquiterpene isolated from the Red Alga Laurencia implicata and its absolute Configuration
Motoo Tori, Katsuyuki Nakashima, Masashi Seike, Yoshinori Asakawa, A. D. Wright, G. M. König, O. Sticher
Tetrahedron, 1994, 35, 3105-3106.
New Diterpenes from the Tropical Brown Alga Dictyota pardalis f. pseudohamata
G. M. König and A. D. Wright
Tetrahedron, 1994, 50, 8011-8018.
Biological Activities of Selected Marine Natural Products
G. M. König, A. D. Wright, O. Sticher, C. K. Angerhofer, J. M. Pezzuto
Planta Med., 1994, 60, 532-537.
Extensive 1D and 2D NMR and X-Ray Studies of Diterpenes Isolated from the Marine Alga Dictyota pardalis f. pseudohamata
G. M. König, A. D. Wright, F. R. Fronczek
J. Nat. Prod., 1994, 57, 1529-1538.
Hagers Handbuch, 5. Auflage, Band 6, Drogen P - Z, 1994: Monographien über die Gattungen Stevia, Teucrium und Pinguicula, G. M. König, C. Goez.
1993
New C15 Acetogenins and Sesquiterpenes from the Marine Red Alga Laurencia sp., c.f.
L. gracilis, G. M. König and A. D. Wright
J. Nat. Prod., 1993, 57, 477.
A Diterpene from the Marine Alga Glossophora kunthii
R. de Nys, A. D. Wright, G. M. König, O. Sticher
Phytochemistry, 1993, 32, 463-465.
New and Highly Oxidised Hydroazulenoid Diterpenes from the Tropical Marine Brown Alga Dictyota volubilis
A. D. Wright, G. M. König, O. Sticher
Tetrahedron, 1993, 49, 571-580.
Seven New Metabolites from the Marine Red Alga Laurencia majuscula
A. D. Wright, G. M. König, R. de Nys, O. Sticher
J. Nat. Prod., 1993, 56, 394-401.
Four new hydroazulenoid diterpenes from the tropical marine alga Dictyota volubilis
G. M. König, A. D. Wright, O. Sticher, H. Rüegger
Planta Med., 1993, 59, 174-178.
Agelorins A and B, 11-Epi-Fistularin-3, Three New Antibacterial Fistularin-3 Derivatives from the Tropical Marine Sponge Agelas oroides
G. M. König, A. D. Wright
Heterocycles, 1993, 36, 1351-1359.
Five New Sesquiterpenes from the Tropical Red Alga Laurencia flexilis
R. de Nys, A. D. Wright, G. M. König, O. Sticher
J. Nat. Prod., 1993, 56, 877-883.
Two Metabolites from the Red Alga Laurencia flexilis
R. de Nys, G. M. König, A. D. Wright and O. Sticher
Phytochemistry, 1993, 34, 725-728.
Ambigol A and B: New Biologically Active Polychlorinated Aromatic Compounds from the Terrestrial Blue Green Alga Fischerella ambigua
B. S. Falch, G. M. König, A. D. Wright, H. Rüegger, O. Sticher, G. Bernardinelli
J. Org. Chem., 1993, 58, 6570-6575.
New Halogenated Furanones from the marine alga Delisea pulchra (cf. fimbriata)
R. de Nys, A. D. Wright, G. M. König, O. Sticher
Tetrahedron, 1993, 46, 11213-11220.
A New Caryophyllene-based Diterpene from the Soft Coral, Cespitularia species
G. M. König, A. D. Wright
J. Nat. Prod., 1993, 56, 2198-2200.
Algal Secondary Metabolites and their Pharmaceutical Potential
G. M. König, A. D. Wright
in: Human Medicinal Agents from Plants, ACS Symposium Series 534, A. D. Kinghorn, M. F. Balandrin (eds.), Washington DC, 1993, 276.
1992
New dolabellane derivatives from the brown alga Dictyota pardalis
A. D. Wright, G. M. König, O. Sticher, P. Lubini, P. Hofmann, M. Dobler
Helv. Chim. Acta, 1992, 74, 1801.
Four new antibacterial sesterterpenes from a marine sponge of the genus Luffariella
G. M. König, A. D. Wright, O. Sticher
J. Nat. Prod., 1992, 55, 174-178.
Two new sesquiterpene isothiocyanates from the marine sponge Acanthella klethra
G. M. König, A. D. Wright, O. Sticher
J. Nat. Prod., 1992, 55, 633-638.
The enhanced role of a lanthanide shift reagent in the structure elucidation, and 1H NMR and 13C NMR characterisation of some marine natural products
A. D. Wright, G. M. König, O. Sticher
Phytochem. Anal., 1992, 3, 73-79.
A diterpene from Dictyota bartayresii
G. M. König, A. D. Wright, R. de Nys, O. Sticher
Phytochemistry, 1992, 31, 2541-2542.
The Application of Two-dimensional Nuclear Magnetic Resonance Methodologies to the Structure Solution of the New Natural Product Tenerol Acetate from Laurencia tenera
A. D. Wright, G. M. König, O. Sticher, H. Rüegger
Phytochem. Anal., 1992, 3, 263-269.
Antimalarial Sesquiterpenes from the Marine Sponge Acanthella klethra
C. K. Angerhofer, G. M. König, A. D. Wright, O. Sticher, J. M. Pezzuto
J. Nat. Prod., 1992, 55, 1787-1789.
Naturstoffe aus Meeresorganismen und höheren Pflanzen
G. M. König, A. D. Wright, S. M. Oechslin, O. Sticher
Vierteljahrsschrift der Naturforschenden Gesellschaft in Zürich, 1992, 137, 207.
Meeresorganismen als Quelle pharmazeutisch bedeutsamer Naturstoffe
G. M. König
Deutsche Apotheker Zeitung, 1992, 132, 673.
Selective screening of natural products: a resource for the discovery of novel antimalarial compounds
C. K. Angerhofer, G. M. König, A. D. Wright, O. Sticher, W. K. Milhous, G. A. Cordell, N. R. Farnsworth, J. M. Pezzuto
in Advances in Natural Products Chemistry, Atta-ur-Rahman (ed.), Harwood Academic Publishers GmbH, 1992, 311.
1991
New Xenicane and Hydroazulenoid Diterpenes from an Australian collection of Dictyota divaricata
G. M. König, A. D. Wright, O. Sticher
Tetrahedron, 1991, 47, 1399-1410.
An NMR Study of four Benzophenanthridine Alkaloids
S. M. Oechslin, G. M. König, K. Oechslin-Merkel, A. D. Wright, A. D. Kinghorn, O. Sticher
J. Nat. Prod., 1991, 54, 519-524.
Diterpenes from the brown alga Dictyota divaricata
G. M. König, A. D. Wright, O. Sticher
Phytochemistry, 1991, 30, 3679-3682.
Five new monoterpenes from the marine red alga Portieria hornemannii
A. D. Wright, G. M. König, O. Sticher, R. de Nys
Tetrahedron, 1991, 47, 5717-5724.
New sesquiterpenes and C15 acetogenins from the marine red alga Laurencia implicata
A. D. Wright, G. M. König, O. Sticher
J. Nat. Prod., 1991, 54, 1025-1033.
New planar chromatographic techniques in natural product analysis
C. A. J. Erdelmeier, G. M. König
Phytochem. Analysis, 1991, 2, 3.
1990
A new polyhalogenated monoterpene from the red alga Plocamium cartilagineum
G. M. König, A. D. Wright, O. Sticher
J. Nat. Prod., 1990, 53, 1615-1618.
Two new dolabellane derivatives from the brown alga Dictyota pardalis
A. D. Wright, G. M. König, O. Sticher
Tetrahedron, 1990, 46, 3851-3858.
New Briaran Diterpenoids from the Gorgonian Coral Junceela gemmacea
B. F. Bowden, J. C. Coll, G. M. König
Australian Journal of Chemistry, 1990, 43, 151.
1989
Chemically mediated interactions between marine organisms
J. C. Coll, B. F. Bowden, P. M. Alino, A. Heaton, G. M. König, R. de Nys, R. H. Willis, P. W. Sammarco, M. N. Clayton
Chemica Scripta, 1989, 29, 383.
The Structure Determination of a Xenicane Diterpene from Xenia garciae
G. M. König, J. C. Coll, B. F. Bowden, J. C. Gulbis, M. F. Mac Kay, S. C. La Barre, D. Laurent
J. Nat. Prod., 1989, 52, 294-299.
1987
The structures of four isomeric dihydrofuran containing cembranoid diterpenes from several species of soft corals
B. F. Bowden, J. C. Coll, A. Heaton, G. M. König, M. A. Bruck, R. E. Cramer, D. E. Klein, P. J. Scheuer
J. Nat. Prod., 1987, 50, 650-659.
Algal overgrowth of alcyonacean soft corals
J. C. Coll, I. R. Price, G. M. König, B. F. Bowden
Mar. Biol., 1987, 96, 129.
Iridoid glucosides in Avicennia officinalis
G. M. König, H. Rimpler, D. Hunkler
Phytochemistry, 1987, 26, 423-427.
1986
The natural products chemistry of alcyonacean soft corals with special reference to the genus Lobophytum
J. C. Coll, B. F. Bowden, G. M. König, R. Braslau
Bull. Soc. Chim. Belg., 1986, 95, 815.
1985
Iridoid glucosides in Avicennia marina
G. M. König, H. Rimpler
Phytochemistry, 1985, 24, 1245-1248.