The first co-authored publication of Lars Jürgenliemke, a member of the newly started GRK2873, was published in Signal Transduction and Targeted Therapy. This research highlight was a close and fruitful collaboration with Prof Evi Kostenis and a former GRK1873 member, Judith Alenfelder, and highlights the fascinating research of Makaía Papasergi-Scott, Georgios Skiniotis, and coworkers. In their publication, they use a cleverly thought-out strategy to gain fascinating insights into the molecular choreography underlying G protein activation.