2024

• Dr. Julian Breidenbach
  Peptidomimetics in Drug Development: Substrates, Titrants, and Inhibitors to Study and Combat SARS-CoV-2 and Proteolysis Targeting Chimeras as ¹⁸F-Tracers

• Dr. Tim Keuler
  Development of Molecular Chimeras Targeting the NLRP3 Inflammasome and HDAC6

2023

• Dr. Lan Phuong Vu
  Tool Compounds to Study Proteolytical Events: Development of von Hippel-Lindau (VHL) Ligands and Combinatorial Generation of Serine Protease Inhibitors
  

2022

• Dr. Carina Wirtz

  Synthesis and Bioanalytical Evaluation of Inhibitors and Tool Compounds for Human, Protozoal, and Viral Cysteine Proteases

2020

• Dr. Christian Steinebach

  Design and Synthesis of Molecular Chimaeras for the Induced Degradation of Tumour-associated Proteins

• Dr. Martin Mangold
  Biological Evaluation of Serine Protease Inhibitors and Inducers of Protein Degradation

• Dr. Patrick Jim Küppers

  Design, Synthesis and Characterization of Heterocyclized Dipeptide Derivatives as Inhibitors for Heterotrimeric Gα_q Proteins

2019

• Dr. Christian Breuer

  Design and Syntheses of Covalent Peptidomimetic Inhibitors for Human Cysteine Cathepsins

• Dr. Erik Gilberg

  Design Computational Analysis of Assay Interference and Compound Promiscuity in Medicinal Chemistry

2018

• Dr. Anna-Christina Schulz-Fincke

  Kinetic and Biological Evaluation of Fluorescent Probes and Irreversible Inhibitors for Selected Human Proteases

2016

• Dr. Anna-Madeleine Beckmann

  Identification and Characterization of Putative Interaction Partners of the Cell Surface Serine Protease Matriptase-2

• Dr. Janina Schmitz

  Synthesis and Biological Evaluation of Nitrile-Based Peptidomimetic Inhibitors for Cysteine Cathepsins

• Dr. Norbert Furtmann
  From Computational Analysis of X-ray Structures of Ligand-Target Complexes to Structure-based Compound Design, Synthesis, and Biochemical Evaluation

• Dr. Daniela Häußler

  Synthesis and Evaluation of Phosphono Dipeptides as Irreversible Inhibitors and Activity-based Probes for Matriptase-2

2014

• Dr. Matthias Mertens

  Coumarin, a Versatile Scaffold in Pharmaceutical Chemistry: Fluorescent Labeling of Amino Acids, Activity-Based Probing of Human Cathepsin S, Monoamine Oxidase B Inhibition and Chiral Derivatization

2013

• Dr. Eva Maurer

  Characterisation of the type II transmembrane serine protease matriptase-2: Analysis of expression, activity modulation and enzyme-ligand interaction

2012

• Dr. Philipp Aaron Ottersbach

  Investigations on Atropisomerism in Azadipeptides and Preparation of Conformationally Constrained Azadipeptides

• Dr. Maxim Frizler
  Development of Selective Nitrile Inhibitors and 'Activity-Based' Probes for Human Cathepsins K and S

2011

• Dr. Stefan Dosa

  Sulfamoylbenzamidine als Arginin-Mimetika: Hemmung von Trypsin-artigen Serinproteasen und Mapping des aktiven Zentrums von Matriptase-2

2010

• Dr. Mihiret Tekeste Sisay

  Virtual compound screening and SAR analysis: method development and practical applications in the design of new serine and cysteine protease inhibitors

• Dr. Hans-Georg Häcker
  Substituted Aromatic (Thio)ureas and Derived Heterocycles as Modulators of P-Glycoprotein and Multidrug Resistance-Associated Protein 1

2008

• Dr. Camino M. Gonzalez

  Enzymkinetische Charakterisierung niedermolekularer Verbindungen als Inhibitoren von Serinhydrolasen

2007

• Dr. Paul Wilhelm Elsinghorst

  Dual-mode cholinesterase inhibitors targeting muscarinic receptors

2006

• Dr. Reik Löser

  Synthese von Dipeptid-Derivaten und deren Interaktion mit Papain-ähnlichen Cysteinproteasen unter besonderer Berücksichtigung von Dipeptidnitrilen

• Dr. Sonja Kolp

  Untersuchungen zur Beeinflussung der Zymogen-Aktivierung durch kompatible Solute und zur proteolytischen Aktivität von Matriptase-2

• Dr. Agnieszka Ambrozak

  Synthesis of 5-Aminobarbituric Acids and Their Conversion to Hydantoins and Bioactive Phthalimido Derivatives

• Dr. Markus Pietsch

  Synthese tricyclischer 1,3-Oxazin-4-one und kinetische Analyse der Hemmung der Cholesterolesterase und der Acetylcholinesterase

2005

• Dr. Manuela Meusel

  Entwicklung neuer Syntheseverfahren für biologisch aktive Ureide und Hydantoine

2024

• Victoria Steiger

  Synthesis and Evaluation of Substrates and Inhibitors for the Main Protease of SARS-CoV-2

• Alexandra Maria Hingst
  Kinetik Investigation on Reactions Catalyzed by the Main Protease of SARS-CoV-2

• Vesa Krasniqi
  Enzyme Kinetic Investigations on Inhibition of Cathepsins and Monoamine Oxidases by Low Molecular Weight Compounds

2023

• Johannes Sievers
  N.N.
  

• Elsjon Sula

  Synthesis of PET Precursors for VHL-based PROTACs

2022

• Marie Möller

  Synthesis and Characterization of a New Non-covalent KEAP1 Ligand for PROTAC Applications

• Sophie Wittenburg

  Synthesis and Physicochemical Characterization of PROTACs Targeting RAF Kinases

2020

• Sabine Anna Voell

  Synthesis of PROTACs Targeting BRAF(V600E)

2019

• Dominik Brajtenbach

  Synthesis of Cyanine-Containing Activity-Based Probes for Cathepsin-K

• Jiafei Yin

  Biochemical Investigation of Inhibitors and Tool Compounds for Different Human Proteases, Esterases and Oxidases

2018

• Lan Phuong Vu

  Synthesis of E3 Ligase Ligands as Building Blocks for PROTACs

• Seyda Teke

  Synthesis of Dipeptidomimetic Carbamates as Cathepsin B Inhibitors and Precursors for Positron Emission Tomography

2017

• Franziska Kohl

  Synthesis and Biological Evaluation of a Novel BIP-V5 Containing PROTAC Targeting the Human Bax Protein

• Carina Lemke

  Development and Enzymatic Characterization of Covalent Inhibitors Adressing Various Human Cathepsins

2016

• Christian Steinebach

  Design of Phthalimide-Conjugates for Bifunctional Ligand-Based Target Protein Degradation

• Polya Georgieva Roydeva

  Untersuchung zur Hemmung von Matriptase-2 durch ausgewählte heterocyclische Verbindungen

• Lisa Reinelt

  Synthese analoger BIM-46187-Derivate

• Tianwei Li

  Kinetic Evaluation and Structural Optimization of Dipeptidyl Nitrile Type Cathepsin B Inhibitors

2015

• Laura Cremer

  Synthesis of Dipeptide Carbamates and Dipeptide Carbonates as Inhibitors of Cysteine proteases

• Tamara Scheidt

  Kinetic Investigations on Pharmaceutically Relevant Serine and Cysteine Proteases with Selected Protease Inhibitors 

• Martin Mangold

  Untersuchungen zur Reinigung und Aktivitätsregulation der rekombinanten humanen Serinprotease Matriptase-2

2013

• Karina Scheiner

  Affibody-based Enzyme Scaffolds for Metabolic Engineering of E. coli and Cyanobacteria for Improved PHB and Butanol Production in Vivo (Universität Bonn / Royal Institute of Technology, Stockholm)

• Anna Beckmann

  Synthesis of 3-Cyano-3-aza-ß-amino Acid Derivatives as Potential Inhibitors of Human Cysteine Proteases

• Verena Lülsdorff

  Charakterisierung von Hepatocyte Growth Factor Activator Type 1 (HAI-1) als Inhibitor der Serinprotease Matriptase-2

• Michael Lülsdorff

  Synthesis of Dipeptidomimetics with Inversely Oriented Warheads and their Inhibitory Activity Against Cathepsin B

• Katharina Arenz

  Evaluation of Nitroxoline-Related Compounds in a 3D In Vitro Tumour Invasion Model (Universität Bonn / University of Ljubljana)

2012

• Franziska Krumbiegel

  Methodenvalidierung eines Alkoholmarkers in Mekonium (Universität Bonn / Institut für Rechtsmedizin der Charité Berlin)

2011

• Daniela Häußler

  Synthese Fluoreszenz-markierter Serinprotease-Inhibitoren 

• Janina Schmitz

  Synthesis and Evaluation of P2-Modified Dipeptide Nitriles as Inhibitors of Cathepsin S

2009

• Matthias Mertens

  Synthesis of N- and O-sulfonylated 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine / Quinazoline Derivatives and Observation of a N-O Sulfonyl Transfer

• Eva Maurer

  Charakterisierung des Aktivierungsmechanismus der Trypsin-ähnlichen Serinprotease Matriptase-2

2012

• Lukáš Hroch

  Preparation of 3,5,5-Trisubstituted Hydantoins From Activated Cbz-Aminomalonic Acids (Universität Bonn / Univerzita Karlova v Praze)

2009

• Friederike Lohr

  Aza-Dipeptidnitrile als potentielle Cysteinprotease-Hemmstoffe: Synthese und enzymkinetische Untersuchungen

• Philipp Aaron Ottersbach

  Synthese von potentiell biologisch aktiven Benzo[1,2-d:4,3-d']bisthiazolen und 3,1-Benzothiazinen

2008

• Cornelius Heß

  17-Hydroxymethyl-17-methyl-18-nor-Derivate als Metaboliten von anabolen androgenen 17alpha-Methyl-Steroiden - massenspektrometrische Charakterisierung und renale Elimination (Universität Bonn / Institut für Biochemie, Deutsche Sporthochschule Köln)

• Maxim Frizler

  Azadipeptidnitrile als Proteaseinhibitoren: Synthese, Stabilität und Papain-Hemmung

2007

• Mihiret Tekeste Sisay

  Homology Modeling and Structural Analysis of the Catalytic Domain of Matriptase-2

• Anne-Katrin Orlovius

  Metabolismus von Stimulanzien: Synthese und direkte Bestimmung von Sulfat-Konjugaten. Ein Beitrag zur Weiterentwicklung des Nachweisverfahrens in der Dopinganalytik (Universität Bonn / Institut für Biochemie, Deutsche Sporthochschule Köln)

2006

• Eva Lepicova

  Investigations on the Darzens Condensation of 2-Bromo-4,6-dimethoxybenzofuran-3(2H)-one (Universität Bonn / Univerzita Karlova v Praze)

• Jürgen Gäb

  Synthese von 4H-3,1-Benzothiazin-4-on-Derivaten als potentielle Liganden von Adenosin-Rezeptoren

2004

• David Bolek

  Syntéza derivátu alfitoninu (Universität Bonn / Univerzita Karlova v Praze)

2002

• Ales Marecek

  Syntéza 2-benzyl-2-hydroxy-2H-benzofuran-3-onu (Universität Bonn / Univerzita Karlova v Praze)

• Abdelazim Sarhan

  Untersuchungen zur Synthese und zur D-Hydantoinase-katalysierten Hydrolyse von Hydantoinen

2001

• Markus Pietsch

  Untersuchungen zur Wechselwirkung von Pankreas-Cholesterolesterase mit niedermolekularen Verbindungen

2000

• Lars Kuerschner 

  Untersuchungen zur Enzymkinetik und zur Enzym-Ligand-Wechselwirkung von Cathepsin G-Inhibitoren