Compound Library (Pharma Center Bonn)
A professional proprietary compound library was established by Christa Müller. She has collected precious compounds since her early days in research.
Since 1998, when she moved from the University of Würzburg to Bonn, she started to organize her compound collection. In 2006, she equipped a dedicated storage and handling room for the compounds, and in 2009, she obtained funding via the Neuroallianz project (BMBF- and industry-funded) to further optimize and professionalize the compound library.
The library will be continuously upgraded and extended aiming at:
- Establishment of a target-focused library comprising of about > 35.000 small molecules and natural products. Current targets include: adenosine receptors (A1, A2A, A2B, A3), P2Y receptors (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, P2Y14), P2X receptors (P2X1, P2X2, P2X3, P2X4, P2X7), ectonucleotidases (various subfamilies and subtypes), cannabinoid receptors, orphan class A G protein-coupled receptors.
- Professional compound management system for the electronic storage of physicochemical, and biological/pharmacological data which is compatible with industrial platforms for effiecient data exchange.
2008
founding year
> 35.000
proprietary compounds
> 6
collaborators
Background
Compounds originating from an academic environment are often discarded after the termination of a research project. Furthermore, valuable compounds may decompose due to inappropriate storage.
High-throughput screening approaches are increasingly utilized not only in pharmaceutical industry but also in academic environment.
Commercially available libraries are expensive and provide only little innovative potential since they can be purchased by everybody.
Concept and Infrastructure
Security
Limited access only to authorized personnel implemented by electronic lock
Compounds from different projects are kept physically separate.
Intellectual Property (IP)
A collaboration agreement will guarantee a fair allocation of IP rights.
Equipment
- Automated liquid handling system
- Cupboards with grids for solid compounds
- Freezers (-20°C) with grids for stock solutions
- Emergency generator
- Air conditioning
- Barcode system for the vials
- Weighing and transferring workstation
- Regular quality control
Planned activities
- Generation of 96- and 384-well plates for screening campaigns
Cooperation and Support
Establishment of the compound library was financially supported by:
- BioPharma Neuroallianz (Project founded by BMBF)
Cooperation partners (selection):
- Prof. Dr. F. Bracher (Department Pharmazie, Zentrum für Pharmaforschung, Ludwig-Maximilians-Universität München)
- Prof. Dr. Stefan Bräse (Institut für Organische Chemie, Karlsruher Institut für Technologie (KIT))
- Prof. Dr. Piet Herdewijn (Laboratory for Medicinal Chemistry, University of Leuven)
- Prof. Dr. Gabriele König (Pharmazeutische Biologie, Universität Bonn)
- Prof. Dr. S. Laufer (Pharmazeutisches Institut, Pharmazeutische Chemie, Eberhard-Karls-Universität Tübingen)
- TOCRIS Bioscience (Bristol, UK)
Zur Erweiterung der strukturellen Diversität der Substanzbibliothek freuen wir uns über weitere Kooperationen.
Contact
Lead compound library
Prof. Dr. Christa MüllerAddress
5th floor, room 5.106
An der Immenburg 4
53121 Bonn
Technical assisant compound library
Christin Vielmuth