Publications and Patents

Here you will find an extensive collection of our scientific publications and registered patents.

Publications

2024

Rabea Voget, Julian Breidenbach, Tobias Claff, Alexandra Hingst, Katharina Sylvester, Christian Steinebach, Lan Phuong Vu, Renato H. Weiße, Ulrike Bartz, Norbert Sträter, Christa E. Müller, Michael Gütschow;
Development of an active-site titrant for SARS-CoV-2 main protease as an indispensable tool for evaluating enzyme kinetics.
Acta Pharmaceutica Sinica B 2024; https://doi.org/10.1016/j.apsb.2024.03.001.
Ghazl Al Hamwi, Vigneshwaran Namasivayam, Beatriz Büschbell, Robin Gedschold, Stefan Golz, Christa E. Müller;
Proinflammatory chemokine CXCL14 activates MAS-related G protein-coupled receptor MRGPRX2 and its putative mouse ortholog MRGPRB2.
Commun. Biol. 2024, 7, 52; https://doi.org/10.1038/s42003-023-05739-5.
Mariam Tahoun, Carole T Gee, Victoria E. Mc Coy, Michael Stoneman, Valerica Raicu, Marianne Engeser, Christa E. Müller;
Suberin, the hallmark constituent of bark, identified in a 45-million-year-old monkeyhair tree (Coumoxylon hartigii) from Geiseltal, Germany.
Scientific Reports 2024, 14, 118; https://doi.org/10.1038/s41598-023-50402-y.
Philipp Flury, Julian Breidenbach, Nadine Krüger, Rabea Voget, Laura Schäkel, Yaoyao Si, Vesa Krasniqi, Sara Calistri, Mattthias Olfert, Katharina Sylvester, Cheila Rocha, Raphael Ditzinger, Alexander Rasch, Stefan Pöhlmann, Thales Kronenberger, Antti Poso, Katharina Rox, Stefan A. Laufer, Christa E. Müller, Michael Gütschow, Thanigaimalai Pillaiyar;
Cathepsin-targeting SARS-CoV-2 inhibitors: design, synthesis, and biological activity.
ACS Pharmacol. Transl. Sci. 2024; https://doi.org/10.1021/acsptsci.3c00313.

2023

Vittoria Lopez, H. J. Maximilian Schuh, Salahuddin Mirza, Victoria J. Vaaßen, Michael S. Schmidt, Katharina Sylvester, Riham M. Idris, Christian Renn, Laura Schäkel, Julie Pelletier, Jean Sévigny, Annamaria Naggi, Björn Scheffler, Sang-Yong Lee, Gerd Bendas, Christa E. Müller;
Heparins are potent inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) – a promising target for the immunotherapy of cancer.
Front. Immunol. 2023, 14, 1173634; doi: 103389/fimmu2023.1173634.
Jan H. Voss, Haneen Al-Hroub, Robin Gedschold, Jennifer M. Dietrich, Evelyn Gaffal, Marieta Toma, Stefan Kehraus, Gabriele M. König, Peter Brust, Bernd K. Fleischmann, Daniela Wenzel, Winnie Deuther-Conrad, Christa E. Müller;

Imaging of Gαq proteins in mouse and human organs and tissues.
Pharmaceutics 2023, 15, 57; https://doi.org/10.3390/pharmaceutics15010057.
Nina Geiger, Viktoria Diesendorf, Valeria Roll, Eva-Maria König, Helena Obernolte, Katherina Sewald, Julian Breidenbach, Thanigaimalai Pillaiyar, Michael Gütschow, Christa E. Müller, Jochen Bodem;
Cell type-specific anti-viral effects of novel SARS-CoV-2 main protease inhibitors.
Int. J. Mol. Sci. 2023, 24, 3972; https://doi.org/10.3390/ijms24043972.
Yuta Tsukamoto, Takahiro Hiono, Shintaro Yamada, Keita Matsuno, Aileen Faist, Tobias Claff, Jianyu Hou, Vigneshwaran Namasivayam, Anja vom Hemdt, Satoko Sugimoto, Jin Ying Ng, Maria H. Christensen, Yonas M. Tesfamariam, Steven Wolter, Stefan Juranek, Thomas Zillinger, Stefan Bauer, Takatsugu Hirokawa, Florian I. Schmidt, Georg Kochs, Masayuki Shimojima, Yi-Shuian Huang, Andreas Pichlmair, Beate M. Kümmerer, Yoshihiro Sakoda, Martin Schlee, Linda Brunotte, Christa E. Müller, Manabu Igarashi, Hiroki Kato;
Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication.
Science 2023, 379, 586-591; https://doi.org/10.3390/ijms24043972.
Małgorzata Frankowska, Karolina Wydra, Agata Suder, Magdalena Zaniewska, Dawid Gawliński, Joanna Miszkiel, Anna Furgała-Wojas, Kinga Sałat, Małgorzata Filip, Christa E. Müller, Katarzyna Kieć-Kononowicz, Magdalena Kotańska;
Novel GPR18 ligands in rodent pharmacological tests: Effects on mood, pain, and eating disorders.
Int. J. Mol. Sci. 2023, 24, 9046; https://doi.org/10.3390/ijms24109046.
Tobias Claff, Jonathan G. Schlegel, Jan H. Voss, Victoria J. Vaaßen, Renato H. Weiße, Robert K. Y. Cheng, Sandra Markovic-Mueller, Denis Bucher, Norbert Sträter, Christa E. Müller;
Crystal structure of adenosine A2A receptor in complex with clinical candidate Etrumadenant reveals unprecendented antagonist interaction.
Commun. Chem. 2023, 6, 106; https://doi.org/10.1038/s42004-023-00894-6.
Pedro Valada, Sonja Hinz, Christin Vielmuth, Cátia R. Lopes, Rodrigo A. Cunha, Christa E. Müller, João Pedro Lopes;
The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine receptors.
Purinergic Signal. 2023, 19, 451-462; https://doi.org/10.1007/s11302-02-09899-7.
Mariam Tahoun, Marianne Engeser, Luca Svolacchia, Paul Martin Sander, Christa E. Müller;
Molecular taphonomy of heme: Chemical degradation of hemin under presumed fossilization conditions.
Molecules 2023, 28, 4887; https://doi.org/10.3390/molecules28134887.
Jan H. Voss, Max Crüsemann, Christian R. O. Bartling, Gabriele M. König, Kristian Strømgaard, Christa E. Müller;
Structure-affinity and structure-residence time relationships of macrocyclis Gαq protein inhibitors.
iScience 2023, 26, 106492; https://doi.org/10.1016/j.isci.2023.106492.
Michał Załuski, Tadeusz Karcz, Anna Drabczyńska, Christin Vielmuth, Agnieszka Olejarz-Maciej, Monika Głuch-Lutwin, Barbara Mordyl, Agata Siwek, Grzegorz Satała, Christa E. Müller, Katarzyna Kieć-Kononowicz;
Xanthine-dopamine hybrid molecules as multitarget drugs with potential for the treatment of neurodegenerative diseases.
Biomolecules 2023, 13, 1079; https://doi.org/10.3390/biom13071079.
Chunyang Bi, Laura Schäkel, Salahuddin Mirza, Katharina Sylvester, Julie Pelletier, Sang-Yong Lee, Thanigaimalai Pillaiyar, Jean Sévigny, Christa E. Müller;
Synthesis and structure-activity relationships of ticlopidine derivatives and analogs as inhibitors of ectonucleotidase CD39.
Bioorg. Chem. 2023, 135, 106360; https://doi.org.10.1016/j.bioorg.2023.106460.
Caterina Giraulo, Roberta Turiello, Lavinia Orlando, Sonia Leonardelli, Jennifer Landsberg, Raffaella Belvedere, Georg Rolshoven, Christa E. Müller, Michael Hölzel, Silvana Morello;
The CD73 is induced by TGF-β1 triggered by nutrient deprivation and highly expressed in dedifferentiated human melanoma.
Biomed. Pharmacother. 2023, 165, 115225; https://doi.org/j.biophar.2023.115225.
Monika Kubacka, Szczepan Mogilski, Marek Bednarski, Krzysztof Pociecha, Artur Swierczek, Noemi Nicosia, Jakub Schabikowski, Michałuski, Grażyna Chłoń-Rzepa, Jörg Hockemeyer, Christa E. Müller, Katarzyna Kieć-Kononowicz, Magdalena, Kotańska;
Antiplatelet effects of selected xanthine-based adenosine A2A and A2B receptor antagonists determined in rat blood.
Int. J. Mol. Sci. 2023, 24, 13378; https://doi.org/10.3390/ijms241713378.
Philipp Wollnitzke, Raphael Wagner, Sumaiya Yasmeen Afsar, Markus Werner, Robin Gedschold, Christa E. Müller, Oliver Werz, Gerhild van Echten-Deckert, Dirk Menche;
Synthesis and biological evaluation of simplified ajudazol derivatives reveal potent 5-lipoxygenase inhibition and considerable apoptotic activity in neuroblastoma cells.
Bioorg. Med. Chem. Lett. 2023, 94, 129464; https://doi.org/10.1016/j.bmcl.2023.129464.
Daniel Marx, Mohamed Wessam Alnouri, Sophie Clemens, Robin Gedschold, Yvonne Riedel, Ghazl Al Hamwi, Thanigaimalai Pillaiyar, Jörg Hockemeyer, Vigneshwaran Namasivayam, Christa E. Müller;
Discovery of potent agonists for the predominant variant of the orphan MAS-related G protein-coupled receptor X4 (MRGPRX4).
J. Med. Chem. 2023, 66, 15674-15698; https://doi.org/10.3390/biom13071079.
Michał Załuski, Dorota Łażewska, Piotr Jaśko, Ewelina Honkisz-Orzechowska, Kamil J. Kuder, Andreas Brockmann, Gniewomir Latacz, Małgorzata Zygmunt, Maria Kaleta, Beril Anita Greser, Agnieszka Olejarz-Maciej, Magdalena Jastrzȩbska-Wiȩsek, Christin Vielmuth, Christa E. Müller, Katarzyna Kieć-Kononowicz;
Anti-inflammatory activities of 8-Benzylaminoxanthines showing high adenosie A2A and dual A1/A2A receptor affinity.
Int. J. Mol. Sci. 2023, 24, 13707; https://doi.org/10.3390/ijms241813707.
Shenghua Gao, Letian Song, Katharina Sylvester, Beatrice Mercorelli, Arianna Loregian, Karoly Toth, Renato H. Weiße, Abibe Useini, Norbert STräter Mianling Yang, Bing Ye, Ann E. Tollefson, Christa E. Müller, Xinyong Liu, Peng Zhan;
Design, synthesis, and biological evaluation of trisubstituted piperazine derivatives as noncovalent severe acute respiratory syndrome coronavirus 2 main protease inhibitors with improved antiviral activity and favorable druggability.
J. Med. Chem. 2023, 66, 16426-16440; https://doi.org/10.1021/acs.jmedchem.3c01876.
Hai-Jun Zhang, Michał Ociepa, Molhm Nassir, Bin Zheng, Sarah A. Lewicki, Veronica Salmaso, Helay Baburi, Jessica Nagel, Salahuddin Mirza, Beatriz Büschbell, Haneen Al-Hroub, Olga Perzanowska, Ziqin Lin, Michael A. Schmidt, Martin D. Eastgate, Kenneth A. Jacobson, Christa E. Müller, Joanna Kowalska, Jacek Jemielity, Phil S. Baran;
Stereocontrolled access to thioisosteres of nucleoside di- and triphosphates.
Nature Chemistry 2023, https://doi.org/10.1038/s41557-023-01347-2.

2022

Odd L. Gammelgaard, Mikkel G. Terp, Christian Renn, Aran F. Labrijn, Oliver Hamaker, Aaraby Y. Nielsen, Henriette Vever, Soren W.K. Hansen, Morten F. Gjerstorff, Christa E. Müller, Paul W.H.I. Parren, Herik J. Ditzel;
Targeting two distinct epitopes on human CD73 with a bispecific antibody improves anticancer activity.
J. Immunother. Cancer 2022, 10:e004554; doi: 10.1136/jitc-2022-004554.
Hanna Kozłowska, Barbara Malinowska, Marta Baranowska-Kuczko, Magdalena Kusaczuk, Miłosz Nesterowicz, Mirosław Kozłowski, Christa E. Müller, Katarzyna Kieć-Kononwicz, Eberhard Schlicker;
GPR18-mediated relaxation of human isolated pulmonary arteries.
Int. J. Mol. Sci. 2022, 23, 1427; https://doi.org/10.3390/ijms23031427.
Sho Konno, Kiyotaka Kobayashi, Miki Senda, Yuta Funai, Yuta Seki, Ikumi Tamai, Laura Schäkel, Thanigaimalai Pillaiyar, Akihiro Taguchi, Atsuhiko Taniguchi, Michael Gütschow, Christa E. Müller, Koh Takeuchi, Mikako Hirohama, Atsushi Kawaguchi, Masaki Kojima, Toshiya Senda, Yoshiyuki Shirasaka, Wataru Kamitani, Yoshio Hayashi;
3CL Protease inhibitors with an electrophilic arylketone moiety as anti-SARS-CoV-2 agents.
J. Med. Chem. 2022, 65, 2926-2939; https://doi.org/101021/acs.jmedchem.1c00665.
Daniel J. Modemann, Andhika B. Mahardhika, Sabrina Yamoune, Anne-Katrin Kreyenschmidt, Frederike Maaß, Sarah Kremers, Christian Breunig, Carsten-Oliver Sahlmann, Jan Bucerius, Dietmar Stalke, Jens Wiltfang, Yvonne Bouter, Christa E. Müller, Caroline Bouter, Birgit Beller,
Development of high-affinity fluorinated ligands for cannabinoid subtype 2 receptor, and in vitro evaluation of a readioactive tracer for imaging.
Eur. J. Med. Chem. 2022, 232, 114138; https://doi.org/10.1016/j.ejmech.2022.114138.
Karolina Losenkova, Akira Tkeda, Symantas Ragauskas, Marc Cerrada-Gimenez, Maria Vähätupa, Simon Kaja, Marius L. Paul, Constanze C. Schmies, Georg Rolshoven, Christa E. Müller, Jouko Sandholm, Sirpa Jalkanen, Giedrius Kalesnykas, Gennady G. Yegutkin;
CD73 controls ocular adenosine levels and protects retina from light-induced phototoxicity.
Cell. Mol. Life Sci. 2022, 79, 152; https://doi.org/10.1007/s0018-022-04187-4.
a) Tobias Claff, Tim A. Klapschinski, Udaya K. Tiruttani Subhramanyam, Victoria J. Vaaßen, Jonathan G. Schlegel, Christin Vielmuth, Jan H. Voß, Jörg Labahn, Christa E. Müller;
Single stabilizing point mutation enables high-resolution co-crystal structures of the adenosine A2A receptor with preladenant conjugates. “Hot paper”, selected for Inside Cover Page.
Angew. Chem. Int. Ed. 2022, e2022115545; doi.org/10.1002/anie.202115545.

b) Tobias Claff, Tim A. Klapschinski, Udaya K. Tiruttani Subhramanyam, Victoria J. Vaaßen, Jonathan G. Schlegel, Christin Vielmuth, Jan H. Voß, Jörg Labahn, Christa E. Müller;
Die einzige stabilisierende Punktmutation ermöglicht hochaufgelöste Co-Kristallstrukutren des Adenosin-A2A-Rezeptors mit Preladenant-Konjugaten.
Angew. Chem. 2022, e202005545; doi.org/ange.202115545.
Mariam Tahoun, Marianne Engeser, Vigneshwaran Namasivayam, Paul Martin Sander, Christa E. Müller;
Chemistry and analysis of organic compounds in dinosaurs. Selected for Cover Page.
Biology 2022, 11, 670; https://doi.org/10.3390/biology 11050670.
Valerie J. Brock, Insa M.A. Wolf, Maroc Er-Lukowiak, Niels Lory, Tobias Stähler, Lena-Marie Woelk, Hans-Willi Mittrücker, Christa E. Müller; Friedrich Koch-Nolte, Björn Rissiek, René Werner, Andreas H. Guse, Björn-Philipp Diercks;
P2X4 and P2X7 are essential players in basal T cell activity and Ca2+ signalling milliseconds after T cell activation.
Sci. Adv. 2022, 8, eabl9770.
Adriaan P. IJzerman, Kenneth A. Jacobson, Christa E. Müller, Bruce N. Cronstein, Rodrigo A Cunha;
International union of basic and clinical pharmacology. CXII: Adenosine receptors: a further update.
Pharmacol. Rev. 2022, 74, 340-372; dx.doi.org/10.1124/pharmrev.121.000445.
Alexander Neumann, Isaac Y. Attah, Haneen Al-Hroub, Vigneshwaran Namasivayam, Christa E. Müller;
Discovery of P2Y2 receptor antagonist scaffolds through virtual high-throughput screening.
J. Chem. Inf. Model. 2022, 62, 1538-1549; https.//doi.org/10.1021/acs.jcim.1c01235.
Mirko Scortichini, Riham Mohammed Idris, Susanne Moschütz, Antje Keim, Veronica Slamaso, Clemens Dobelmann, Paola Oliva, Karolina Losenkova, Heikki Irjala, Samuli Vaittinen, Jouko Sandholm, Gennady G. Yegutkin, Norbert Sträter, Anna Junker, Christa E. Müller, Kenneth A. Jacobson;
Structure-activity relationship of 3-methylcytidine-5’-α,β-methylenediphosphates as CD73 inhibitors.
J. Med. Chem. 2022, 65, 2409-2433; https://doi.org.10.1021/acsjmedchem.1c01852.
Bianca Schulte, Maria König, Beate I. Escher, Sophie Wittenburg, Matic Proj, Valentina Wolf, Carina Lemke, Gregor Schnakenburg, Izidor Sosič, Hendrik Streeck, Christa E. Müller, Michael Gütschow, Christian Steinebach;
Andrographolide derivatives target the KEAP1/NRF2 axis and possess potent anti-SARS-CoV-2 activity.
ChemMedChem 2022, 17, e202100732; doi.org/10.1002/cmdc.202100732.
Jan Hendrik Voss, Andhika B. Mahardhika, Asuka Inoue, Christa E. Müller;
Agonist-dependent coupling of the promiscuous adenosine A2B receptor to Gα protein subunits.
ACS Pharmacol. Transl. Sci. 2022, 5, 373-386; https://doi.org/10.1021/acsptsci.2c00020.
Bastian Mähler, Kathrin Janssen, Mariam Tahoun, Frank Tomaschek, Rico Schellhorn, Christa E. Müller, Gabriele Bierbaum, Jes Rust;
Adipocere formation in biofilms as a first step in soft tissue preservation.
Sci. Rep. 2022, 12:10122. doi: 10.1038/s41598-022-14119-8.
Isabel Paiva, Lucrezia Cellai, Céline Meriaux, Lauranne Poncelet, Ouda Nebie, Jean-Michel Saliou, Anne-Sophie Lacoste, Anthony Papegaey, Hervé Drobecq, Stéphanie Le Gras, Marion Schneider, Enas M. Malik, Christa E. Müller, Emilie Faivre, Kevin Carvalho, Victoria Gomez-Murcia, Didier Vieau, Bryan Thiroux, Sabiha Eddarkaoui, Thibaud Lebouvier, Estelle Schueller, Laura Tzeplaeff, Iris Grgurina, Jonathan Seguin, Jonathan Stauber, Luisa V. Lopes, Luc Buée, Valérie Buée-Scherrer, Rodriga A. Cunha, Rima Ait-Belkacem, Nicolas Sergeant, Jean-Sébastien Annicotte, Anne-Laurence Boutillier, David Blum;
Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription.
J. Clin. Invest. 2022, 132: e149371; doi: 10.1172/JCI149371.
Christa E. Müller, Tobias Claff;
Activated microglia nibbling glycosaminoglycans from spinal cord perineural nets: a new mechanism for neuropathic pain.
Signal Transduction and Targeted Therapy 2022, 7: 333; https://doi.org/10.1038/s41392-022-01162-0.
Julie Companys-Alemany, Andreea L. Turcu, Marion Schneider, Christa E. Müller, Santiago VázqueZ, Christian Griñan-Ferré, Mercè Pallàs;
NMDA receptor antagonists reduce amyloid-β deposition by modulating calpain-1 signaling and autophagy, rescuing cognitive impairment in 5XFAD mice.
Cell. Mol. Life Sci. 2022, 79:408; https://doi.org/10.1007/s00018-022-04438-4.
Thanigaimalai Pillaiyar, Philipp Flury, Nadine Krüger, Haicia Su, Laura Schäkel, Elany Barbosa Da Silva, Olga Eppler, Thales Kronenberger, Tianqing Nie, Stephaie Luedtke, Cheila Rocha, Katharina Sylvester, Marvin R. I., James H. McKerrow, Anti Poso, Stefan Pöhlmann, Michael Gütschow, Anthony J. O'Donoghue, Yechun Xu, Christa E. Müller, Stefan A. Laufer;
Small-molecule thioesters as SARS-CoV-2 main protease inhibitors: Enzyme inhibition, structure-activity relationships, antiviral activity, and X-ray structure determination.
J. Med. Chem. 2022, 65, 9376-9395; doi: 10.1021/acs.jmedchem.2c00636.
Jan H. Voss, Christa E. Müller;
Heterotrimeric G protein α-subunits – structures, peptide-derived inhibitors, and mechanisms.
Curr. Med. Chem. 2022, 29, 6359-6378; https://doi.org/10.2174/0929867329666220308112424.
Michał Abram, Marcin Jakubiec, Katelyn Reeb, Mary Hongying Cheng, Robin Gedschold, Anna Rapacz, Szczepan Mogilski, Katarzyna Socała, Dorota Nieoczym, Małgorzata Szafarz, Gniewomir Latacz, Bartłomiej Szulczyk, Justyna Kalinowska-Tłuścik, Kinga Gawel, Camila V. Esguerra, ElżbietaWyska, Christa E. Müller, Ivet Bahar, Adréia C. K. Fontana, Piotr Wlaź, Rafał M. Kamiński, Krysztof Kamiński;
Discovery of (R)-N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide [(R)-AS-1], a novel orally bioavailable EAAT2 modulator with drug-like properties and potent antiseizure activity in vivo.
J. Med. Chem. 2022, 65, 11703-11725; https://doi.org/10.1021/acs.jmedchem.2c00534.
Shenghua Gao, Letian Song, Tobias Claff, Molly Woodson, Katharina Sylvester, Lanlan Jing, Renato H. Weiße, Yusen Cheng, Norbert Sträter, Laura Schäkel, Michael Gütschow, Bing Ye, Mianling Yang, Tao Zhang, Donwei Kang, Karoly Toth, John Travis, Ann E. Tollesfson, Christa E. Müller, Pent Zahn, Xinyong Liu;
Discovery and crystallographic studies of nonpeptidic piperazine derivatives as covalent SARS-CoV-2 main protease inhibitors.
J. Med. Chem. 2022, 65, 16902-16917: https://doi.org/10.1021/acs/jmedchem.2c01716 .
Andhika B. Mahardhika, Anastasiia Ressemann, Sarah E. Kremers, Mariana S. Gregório Castanheira, Clara T. Schoeder, Christa E. Müller, Thanigaimalai Pillaiyar;
Design, synthesis, and structure-activity relationships of diindolylmethane derivatives as cannabinoid CB2 receptor agonists.
Arch. Pharm. 2022, e2200493; https://doi.org/10.1002/ardp.202200493.
Stephanie Weinhausen, Jessica Nagel, Vigneshwaran Namasivayam, Claudia Spanier, Aliaa Abdelrahman, Theodor Hanck, Ralf Hausmann, Christa E. Müller;
Extracellular binding sites of positive and negative allosteric P2X4 receptor modulators.
Life Sci. 2022, 121143; https://doi.org/10.1016/j.lfs.2022.121143.
Magdalena Kotańska, Anna Dziubina, Małgorzata Szafarz, Kamil Mika, Marek Bednarski, Noemi Nicosia, Ahmed Temirak, Christa E. Müller, Katarzyna Kieć-Kononowicz;
Preliminary evidence of the potent and selective adenosine A2B receptor antagonist PSB-603 in reducing obesity and some of its associated metabolic disorders in mice.
Int. J. Mol. Sci. 2022, 23, 13439; https://doi.org/10.3390/ijms232113439.
Birte Niemann, Saskia Haufs-Brusberg, Laura Puetz, Martin Feickert, Michelle Y Jaeckstein, Anne Hoffmann, Jelena Zurkovic, Markus Heine, Eva-Maria Trautmann, Christa E. Müller, Anke Tönjes, Christian Schlein, Azin Jafari, Holger K Eltzschig, Thorsten Gnad, Matthias Blüher, Natalie Krahmer, Peter Kovacs, Joerg Heeren, Alexander Pfeifer;
Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine.
Nature 2022, 609, 361-368; https://doi.org/10.1038/s41586-022-05041-0.
Shenghua Gao, Katharina Sylvester, Letian Song, Tobias Claff, Lanlan Jing, Molly Woodson, RenatoH. Weiße, Yusen Cheng, Laura Schäkel, Marvin Petry, Michael Gütschow, Anke C. Schiedel, Norbert Sträter, Dongwei Kang, Shujing Xu, Karoly Toth, John Travis, Ann E. Tollefson, Christa E. Müller, Xinyong Liu, Peng Zhan;
Discovery and crystallographic studies of trisubstituted piperazine derivatives as non-covalent SARS-CoV-2 main protease inhibitors with high target specifity and low toxicity.
J. Med. Chem. 2022, 65, 13343-13364; https://doi.org/10.1021/acs.jmedchem.2c01146.
Laura Schäkel, Salahuddin Mirza, Riekje Winzer, Vittoria Lopez, Riham Idris, Haneen Al-Hroub, Julie Pelletier, Jean Sévigny, Eva Tolosa, Christa E. Müller;
Protein kinase inhibitor ceritinib blocks ectonucleotidase CD39 – a promising target for cancer immunotherapy;
J. Immunother. Cancer 2022, 10:e004660; doi:10.1136/jitc-2022-004660.
Ghazl Al Hamwi, Yvonne Riedel, Sophie Clemens, Vigneshwaran Namasivayam, Dominik Thimm, Christa E. Müller;
MAS-related G protein-coupled receptors X (MRGPRX): Orphan GPCRs with potential as targets for future drugs.
Pharmacology & Therapeutics 2022, 239, 108259; https://doi.org/10.1016/j.pharmthera.2022.108259.
Christa E. Müller, Vigneshwaran Namasivayam. Agonists, Antagonists, and Modulators of P2X7 Receptors. In: Nicke, A. (eds) The P2X7 Receptor. Methods in Molecular Biology, vol 2510. Humana, New York 2022; https://doi.org/10.1007/978-1-0716-2384-8_2.

2021

Jan H. Voss, Jessica Nagel, Muhammad Rafehi, Ramon Guixá-González, Davide Malfacini, Julian Patt, Stefan Kehraus Asuka Inoue, Gabriele M. König, Evi Kostenis, Xavier Deupi, Vigneshwaran Namasivayam, Christa E. Müller; Unraveling binding mechanism and kinetics of macrocyclic Gαq protein inhibitors. Pharmacol. Res. 2021, 153, 105880; https://doi.org/10.1016/j.phrs.2021.105880
Enja Schneider, Riekje Winzer, Anne Rissiek, Isabell Ricklefs, Catherine Meyer-Schwesinger, Franz L. Ricklefs, Andreas Bauche, Jochen Behrends, Rudolph Reimer, Santra Brenna, Hauke Wasielewski, Melchior Lauten, Brörn Rissiek, Berta Puig, Filippo Cortesi, Tim Magnus, Ralf Fliegert, Christa E. Müller, Nicola Gagliani, Eva Tolosa; CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression. Nat. Commun. 2021, 12, 5911; https://doi.org/10.1038/s41467-021-26134-w.
Laura Schäkel, Salahuddin Mirza, Markus Pietsch, Sang-Yong Lee, Tim Keuler, Katharina Sylvester, Julie Pelletier, Jena Sévigny, Thanigaimalai Pillaiyar, Vigneshwaran Namasivayam, Michael Gütschow, Christa E. Müller; 2-Substituted thienotetrahydropyrindine derivatives: Alleosteric ectonucleotidase inhibitors. Arch. Pharm. 2021, e2100300; https://doi.org/10.1002/ardp.202100300.
Sarah Leitzen, Matthias Vogel, Michael Steffens, Thomas Zapf, Christa E. Müller, Martin Brandl; Quantification of degradation products formed during heat sterilization of glucose solutions by LC-MS/MS: Impact of autoclaving temperature and duration on degradation. Pharmaceuticals 2021, 14, 1121; https://doi.org/10.3390/ph14111121.
Max Braune, Nico Scherf, Claudia Heine, Katja Sygnecka, Thanigaimalai Pillaiyar, Chiara Parravicini, Bernd Heimrich, Maria P. Abbracchio, Christa E. Müller, Heike Franke; Involvement of GPR17 in neuronal fibre outgrowth. Int. J. Mol. Sci. 2021, 22, 11683; https://doi.org/10.3390/ijms222111683.
Thanigaimalai Pillaiyar, Francesca Rosato, Monika Wozniak, Jeremy Blavier, Maëlle Charles, Céline Laschet, Thales Kronenberger, Christa E. Müller, Julien Hanson; Structure-activity relationships of agonists for the orphan G protein-coupled receptor GPR27. Eur. J. Med. Chem. 2021, 225, 113777; https://doi.org/10.1016/j.ejmech.2021.113777.
Magdalena Kotańska, Monika Kubacka, Marek Bednarski, Noemi Nicosia, Małgorzata Szafarz, Wokciech Jawień, Christa E. Müller, Katarzyna Kieć-Kononowicz; The GPR18 agonist PSB-KD-107 exerts endothelium-dependent vasorelaxant effects; Pharmaceuticals 2021, 14, 799; https://doi.org/10.3390/ph14080799.
Thanigaimalai Pillaiyar, Masoud Sedaghati, Andhika B. Mahardhika, Lukas L. Wendt, Christa E. Müller; Iodine-catalyzed electrophilic substitution of indoles: Synthesis of (un)symmetriyal diindoylmethanes with a quarternary carbon center. Beilstein J. Org. Chem. 2021, 17, 1464-1475.
Katharina Wolf, Helen Kühn, Felicitas Boehm, Lisa Gebhardt, Markus Glaudo, Konstantin Agelopoulos, Sonja Ständer, Philipp Ectors, Dirk Zahn, Yvonne K. Riedel, Dominik Thimm, Christa E. Müller; Sascha Kretschmann, Anita N. Kremer, Daphne Chien, Nathachit Limjunyawong, Qi Peng, Xinzhong Dong, Pavel Kolkhir, Jörg Scheffel, Mia Lykk SØgaard, Benno Weigmann, Markus F. Neurath, Tomasz Hawro, Martin Metz, Michael J. M. Fischer, Andreas E. Kremer; A group of cationic amphiphilic drugs activates MRGPRX2 and induces scratching behavior in mice. J. Allergy Clin. Immunol. 2021, 148, 506-522e8; https://doi.org.10.1016/j.jaci.2020.12.655.
Jonathan G. Schlegel, Mariam Tahoun, Alexander Seidinger, Jan H. Voss, Markus Kuschak, Stefan Kehraus, Marion Schneider, Michaela Matthey, Bernd K. Fleischmann, Gabriele M. König, Daniela Wenzel, Christa E. Müller; Macrocyclic Gq protein inhibitors FR900359 and/or YM-254890 – Fit for translation? ACS Pharmacol. Transl. Sci. 2021, 4, 888-897; https://dx.doi.org/10.1021/ascptsci.1x00021.
Sho Konno, Kiyotaka Kobayashi, Miki Senda, Yuta Funai, Yuta Seki, Ikumi Tamai, Laura Schäkel, Thanigaimalai Pillaiyar, Akihiro Taguchi, Atsuhiko Taniguchi, Michael Gütschow, Christa E. Müller, Koh Takeuchi, Mikako Hirohama, Atsushi Kawaguchi, Masaki Kojima, Toshiya Senda, Yoshiyuki Shirasaka, Wataru Kamitani, Yoshio Hayashi;
3CL Protease inhibitors with an electrophilic arylketone moiety as anti-SARS-CoV-2 agents.J. Med. Chem. 2021. https://doi.org/101021/acs.jmedchem.1c00665.
Christa E. Müller;
Accelerating translation of innovative drugs from bench to patients: ACS Pharmacology and Translational Science to evolve, grow, and bridge the gap between chemistry and biology in drug research and development.ASC Pharmacol. Transl. Sci. 2021; https://doi.org/101021.acsptsci.1c00124.
Thanigaimalai Pillaiyar, Masoud Sedaghati, Andhika B. Mahardhika, Lukas L. Wendt, Christa E. Müller;
Iodine-catalyzed electrophilic substitution of indoles: Synthesis of (un)symmetriyal diindoylmethanes with a quarternary carbon center. Beilstein J. Org. Chem. 2021, 17, 1464-1475. https://doi.org/10.3762/bjoc.17.102
Wiebke Hanke, Julian Patt, Judith Alenfelder, Jan H. Voss, Mitja M. Zdouc, Stefan Kehraus, Jung Bong Kim, Goran V. Grujičić, Vigneshwaran Namasivayam, Raphael Reher, Christa E. Müller, Evi Kostenis, Max Crüsemann, Gabriele M. König;
Feature-based molecular networking for the targeted identification of Gq-inhibiting FR900359 derivatives.J. Nat. Prod. 2021, 84, 1941-1953; https://doi.org/10.1021/acs.jnatprod.1c00194.
Stefanie Hagenow, Anna Affini, Elsa Y. Pioli, Sonja Hinz, Yan Zhao, Gregory Porras, Vigneshwaran Namasivayam, Christa E. Müller, Jina-Sheng Lin, Erwan Bezard, Holger Stark;
Adenosine A2AR/A1R antagonists of enabling additional H3R antagonism for the treatment of Parkinson’s disease.J. Med. Chem. 2021, 64, 8246-8262; https://doi.org/10.1021/acs.jmedchem.0c00914.
Sang-Yong Lee, Vigneshwaran Namasivayam, Nader M. Boshta, Arianna Perotti, Salahuddin Mirza, Silvia Bua, Claudiu T. Supuran, Christa E. Müller;
Discovery of potent nucleotide pyrophosphatase/phosphodiesterase3 (NPP3) with ancillary carbonic anhydrase inhibition for cancer (immune)therapy.RCS Med. Chem. 2021, 12, 1187-1206; https://doi.rog/10.1039/d1md00117e.
Marcel Lindemann, Sladjana Dukic-Stefanovic, Sonja Hinz, Winnie Deuther-Conrad, Rodrigo Teodoro, Cathleen Juhl, Jörg Steinbach, Peter Brust, Christa E. Müller, Barbara Wenzel;
Synthesis of a novel fluorinated xanthine derivatives with high adenosine A2B receptor binding affinity.Pharmaceuticals 2021, 14, 485; https://doi.rog/10.3390/ph14050485.
Julian Patt, Judith Alenfelder, Eva Marie Pfeil, Jan Hendrik Voss, Nicole Merten, Funda Eryilmaz, Nina Heycke, Uli Rick, Asuka Inoue, Stefan Kehraus, Xavier Deupi, Christa E. Müller, Gabriele M. König, Max Crüsemann, Evi Kostenis;
An experimental strategy to probe Gq contribution to signal transduction in living cells. J. Biol. Chem. 2021, 296, 10047; https://doi.org/10.1016/j.bc.2021.100472.
Magdalena Kotańska, Małgorzata Szafarz, Kamil Mika, Anna Dziubina, Marek Bednarski, Christa E. Müller, Jacek Sapa, Katrzyna, Kieć-Kononowicz;
PSB 603 – a known selective adenosine A2B receptor antagonist – has anti-inflammatory activity in mice.Biomed. Pharmacother. 2021, 135, 111164; https://doi.org/10.1016/j.biopha.2020.111164.
Peter Illes, Christa E. Müller, Kenneth A. Jacobson, Thomas Grutter, Annette Nicke, Samuel J. Fountain, Charles Kennedy, Günther Schmalzing, Michael F. Jarvis, Stanko S. Stojilkovic, Brian F. King, Francesco Di Virgilio;

Update of P2X receptor properties and their pharmacology: IUPHAR Review 30.
Br. J. Pharmacol. 2021, 178, 489-514; https://doi: 101111/bph.15299.
Danyal Zahiri, Philipp Burow, Claudia Großmann, Christa E. Müller, Manuela Kapperstück, Fritz Markwart;
Sphingosine-1-phosphate induces migration of microglial cells via activation of volume-sensitive anion channels, ATP secretion and activation of purinergic receptors.
BBA – Mol. Cell Res. 2021, 1868, 118915; doi:10.1016/j.bbamcr.2020.118915.
Reiner Schneider, Patrick Leven, Tim Glowka, Ivan Kuzmanov, Mariola Lysson, Bianca Schneiker, Anna Miesen, Younis Baqi, Claudia Spanier, Ivetta Grants, Elvio Mazzotta, Egina Villalobos-Hernandez, Jörg C. Kalff, Christa E. Müller, Fedias L. Christofi, Sven Wehner;
A novel P2X2-dependent purinergic mechanism of enteric gliosis in intestinal inflammation.EMBO Mol. Med. 2021, 13, e12724. https://doi.org/10.15252/emmm.202012724

Azeem Danish, Robin Gedschold, Sonja Hinz, Anke C. Schiedel, Dominik Thimm, Peter Bedner, Christian Steinhäuser, Christa E. Müller; A cellular assay for the identification and characterization of connexin gap junction modulators. Int. J. Mol. Sci. 2021, 22, 1417; https://doi.org./10.3390/ijms22031417

Vittoria Lopez, Laura Schäkel, H. J. Maximilian Schuh, Michael S. Schmidt, Salahuddin Mirza, Christian Renn, Julie Pelletier, Sang-Yong Lee, Jean Sévigny, Susanne Alban, Gerd Bendas, Christa E. Müller;
Sulfated polysaccharides from macroalgae are potent dual inhibitors of human ATP-hydrolyzing ectonucleotidases NPP1 and CD39.
Mar. Drugs 2021, 19, 51. https://doi.org/10.33909/md19020051.
Cornelia Hermes, René Richarz, Daniel A. Wirtz, Julian Patt, Wiebke Hanke, Stefan Kehraus, Jan Hendrik Voß, Jim Küppers, Tsuba Ohbayashi, Vigneshwaran Namasivayam, Judith Alenfelder, Asuka Inoue, Peter Mergaert, Michael Gütschow, Christa E. Müller, Evi Kostenis, Gabriele M. König, Max Crüsemann;
Thioesterase-mediated side chain transesterification generates potent Gq signaling inhibitor FR900359.
Nature Commun. 2021, 12, 1-12; https://doi.org/10.1038/ss41467-020-20418-3
Mariam Tahoun, Carole T. Gee, Victoria E. McCoy, P. Martin Sander, Christa E. Müller;

Chemistry of porphyrins in fossil plants and animals.
RSC Adv. 2021, 11, 7552-7536. https:/doi.org/10.1039/D0RA10688G
Marjorie A. Carnero Corrales, Sarah Zinken, Georgios Konstantinidis, Muhammad Rafehi, Aliaa Abdelrahman, Yao-Wen Wu, Petra Janning, Christa E. Müller, Luca Laraia, Herbert Waldmann;
Thermal proteome profiling indentifies the membrane- bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin.
Cell Chem. Biol. 2021, 28, 1-8; https://doi.org/10.1016/j.chembiol.2021.02.017
a) Julian Breidenbach, Carina Lemke, Thanigaimalai Pillaiyar, Laura Schäkel, Ghazl Al Hamwi, Miriam Diett, Robin Gedschold, Nina Geiger, Vittoria Lopez, Salahuddin Mirza, Vigneshwaran Namasivayam, Anke C. Schiedel, Katharina Sylvester, Dominik Thimm, Christin Vielmuth, Lan Phuong Vu, Maria Zyulina, Jochen Bodem, Michael Gütschow, Christa E. Müller;
Targeting the main protease of SARS-CoV-2: From the establishment of high throughput screening to the design of tailored inhibitors.
Angew. Chem. Int. Ed. 2021, 60, 10423-10429; https://doi.org/10.1002/anie.202016961.

b) Julian Breidenbach, Carina Lemke, Thanigaimalai Pillaiyar, Laura Schäkel, Ghazl Al Hamwi, Miriam Diett, Robin Gedschold, Nina Geiger, Vittoria Lopez, Salahuddin Mirza, Vigneshwaran Namasivayam, Anke C. Schiedel, Katharina Sylvester, Dominik Thimm, Christin Vielmuth, Lan Phuong Vu, Maria Zyulina, Jochen Bodem, Michael Gütschow, Christa E. Müller;
Die Hauptprotease von SARS-CoV-2 als Zielstruktur: Von der Etablierung eines Hochdurchsatz-Screenings zum Design maßgeschneiderter Inhibitoren.
Angew. Chem. 2021, 133, 10515-10521; doi.org/101002/ange.202016961
Magdalena Kotańska, Kamil Mika, Małgorzata Szafarz, Monika Kubacka, Christa E. Müller, Jacek Sapa, Katarzyna Kieć-Kononowicz;

Effects of GPR18 ligands on body weight and metabolic parameters in a female rat model of excessive eating.
Pharmaceuticals 2021, 14, 270; https://doi.org/10.3390/ph14030270.
Jonathan G. Schlegel, Mariam Tahoun, Alexander Seidinger, Jan H. Voss, Markus Kuschak, Stefan Kehraus, Marion Schneider, Michaela Matthey, Bernd K. Fleischmann, Gabriele M. König, Daniela Wenzel, Christa E. Müller;
Macrocyclic Gq protein inhibitors FR900359 and/or YM-254890 – Fit for translation?
ACS Pharmacol. Transl. Sci. 2021; https://dx.doi.org/10.1021/ascptsci.1x00021
Katharina Wolf, Helen Kühn, Felicitas Boehm, Lisa Gebhardt, Markus Glaudo, Konstantin Agelopoulos, Sonja Ständer, Philipp Ectors, Dirk Zahn, Yvonne K. Riedel, Dominik Thimm, Christa E. Müller; Sascha Kretschmann, Anita N. Kremer, Daphne Chien, Nathachit Limjunyawong, Qi Peng, Xinzhong Dong, Pavel Kolkhir, Jörg Scheffel, Mia Lykk SØgaard, Benno Weigmann, Markus F. Neurath, Tomasz Hawro, Martin Metz, Michael J. M. Fischer, Andreas E. Kremer;
A group of cationic amphiphilic drugs activates MRGPRX2 and induces scratching behavior in mice.
J. Allergy Clin. Immunol. 2021, https://doi.org.10.1016/j.jaci.2020.12.655

2020

Marcel Lindemann, Rareş-Petru Moldovan, Sonja Hinz, Winnie Deuther-Conrad, Daniel Gündel, Sladjana Dukic-Stefanovic, Magali Toussaint, Rodrigo Teodoro, Cathleen Juhl, Jörg Steinbach, Peter Brust, Christa E. Müller, Barbara Wenzel;
Development of a radiofluorinated adenosine A_2B receptor antagonist as potential ligand for PET imaging.
J. Int. Mol. Sci. 2020, 21, 3197; doi: 10.3390/ijms21093197.
Sanjay Bhattarai, Jan Pippel, Emma Rose Scaletti, Riham Idris, Marianne Freundlieb, Georg Rolshoven, Christian Renn, Sang-Yong Lee, Aliaa Abdelrahman, Herbert Zimmermann, Ali El-Tayeb, Christa E Müller, Norbert Sträter;
2-Substituted α,β methylene-ADP derivatives: Potent competitive ecto-5′-nucleotidase (CD73) inhibitors with variable binding modes.
J. Med. Chem. 2020, 63, 2941-2957; doi: 10.1021/acs.jmedchem.9b01611.
Isaac Yaw Attah, Alexander Neumann, Haneen Al-Hroub, Muhammad Rafehi, Younis Baqi, Vigneshwaran Namasivayam, Christa E. Müller;
Ligand binding and activation of UTP-activated G protein-coupled P2Y₂ and P2Y₄ receptors elucidated by mutagenesis, pharmacological and computational studies.
Biochim. Biophys. Acta Gen. Subj. 2020, 1864, 129501.
Aliaa Abdelrahman, Swapnil G. Yerande, Vigneshwaran Namasivayam, Tim A. Klapschinski, Mohamed Wessam Alnouri, Ali El-Tayeb, Christa E. Müller;
Substituted 4-phenylthiazoles: Development of potent and selective A₁, A₃and dual
A₁/A₃ adenosine receptor antagonists.
Eur J. Med. Chem. 2020, 186, 111879.
Elisabetta De Filippo, Sonja Hinz, Veronica Pellizzari, Giuseppe Deganutti, Ali El-Tayeb, Gemma Navarro, Rafael Franco, Stefano Moro, Anke C. Schiedel, Christa E. Müller;
A_2A and A_2B adenosine receptors: The extracellular loop 2 determines high (A_2A) or low affinity (A_2B) for adenosine.
Biochem. Pharmacol. 2020, 172, 113718; https://doi.org/10.1016/j.bcp.2019.113718.
Stephan Scheeff, Solenne Rivière, Johal Ruiz, Aliaa Abdelrahman, Anna-Christina Schulz-Fincke, Meryem Köse, Felix Tiburcy, Helmut Wieczorek, Michael Gütschow, Christa E. Müller, Dirk Menche;
Synthesis of novel potent archazolids: Pharmacogy of an emerging class of anticancer drugs.
J. Med. Chem. 2020; https://dx.doi.org/10.1021/acs.jmedchem.9b01887.
Thanigaimalai Pillaiyar, Mario Funke, Haneen Al-Hroub, Stefanie Weyler, Sabrina Ivanova, Aliaa Abdelrahman, Christa E. Müller;
Design, synthesis and biological evaluation of suramin-derived dual antagonists of the proinflammatory G protein-coupled receptors P2Y2 and GPR17.
Eur. J. Med. Chem. 2020, 186, 111789.
Markus Kuschak, Vigneshwaran Namasivayam, Muhammad Rafehi, Jan H. Voss, Jaspal Garg, Jonathan G. Schlegel, Aliaa Abdelrahman, Stefan Kehraus, Raphael Reher, Jim Küppers, Katharina Sylvester, Sonja Hinz, Michaela Matthey, Daniela Wenzel, Bernd K. Fleischmann, Alexander Pfeifer, Asuka Inoue, Michael Gütschow, Gabriele M. König, Christa E. Müller;
Cell-permeable high-affinity tracers for G_q proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors.
Br. J. Pharmacol. 2020, 177, 1898-1916; https://doi.org/10.1111/bph.14960.
Christa E. Müller, Younis Baqi, Vigneshwaran Namasivayam;
Agonists and antagonists for purinergic receptors.
Methods Mol. Biol. 2020, 2041, 45-64; doi: 10.1007/978-1-4939-9717-6_3.
Meryem Köse, Thanigaimalai Pillaiyar, Vigheshwaran Namasivayam, Elisabetta De Filippo, Katharina Sylvester, Trond Ulven, Ivar von Kügelgen, Christa E. Müller; An agonist radioligand for the proinflammatory lipid-activated G protein-coupled receptor GPR84 providing structural insights.
J. Med. Chem. 2020, DOI: 10.1021/acs.jmedchem.9b01339.
Yue Zhang, Carolyn M. Ecelbarger, Lisa A. Lesniewski, Christa E. Müller, Bellamkonda K. Kishore;
P2Y₂ receptor promotes high-fat diet-induced obesity.
Front Endocrinol. 2020, 11, 1-19; doi: 10.3389/fendo.2020.00341
Christa E. Müller, Younis Baqi, Vigneshwaran Namasivayam;
Agonists and antagonists for purinergic receptors.
Methods Mol. Biol. 2020, 2041, 45-64; doi: 10.1007/978-1-4939-9717-6_3
Vittoria Lopez, Sang-Yong Lee, Holger Stephan, Christa E. Müller;
Recombinant expression of ecto-nucleotide prophosphatase/phosphodiesterase 4 (NPP4) and development of luminescence-based assay to identify inhibitors.
Analyt. Biochem. 2020, 603, 113774
Michał Załuski, Jakub Schabikowski, Piotr Jaśko, Adrian Bryła, Agnieszka Olejarz-Maciej, Maria Kaleta, Monika Głuch-Lutwin, Andreas Brockmann, Sonja Hinz, Małgorzata, Zygmunt, Kamil Kuder, Gniewomir Latacz, Christin Vielmuth, Christa E. Müller, Katarzyna Kieć-Kononowicz;
8-Benzylaminoxanthine scaffold variations for selective ligands acting on adenosine A_2A receptors. Design, synthesis and biological evaluation.
Bioorg. Chem. 2020, 101, 104033
Wenjin Li, Joren Guillaume, Younis Baqi, Isabell Wachsmann, Volkmar Gieselman, Serge Van Calenbergh, Christa E. Müller;
Synthesis and structure-activity relationships of cerebroside analogues as substrates of cerebroside sulphotransferease and discovery of a coempetitive inhibitor.
J. Enzym. Inhib. Med. Chem. 2020, 35, 1503-1512; https://doi.org/10.1080/14756366.2020.1791841
Stephan Scheeff, Solenne Rivière, Johal Ruiz, Aliaa Abdelrahman, Anna-Christina Schulz-Fincke, Meryem Köse, Felix Tiburcy, Helmut Wieczorek, Michael Gütschow, Christa E. Müller, Dirk Menche;
Synthesis of novel potent archazolids: Pharmacogy of an emerging class of anticancer drugs.
J. Med. Chem. 2020, 63, 1684-1698; https://dx.doi.org/10.1021/acs.jmedchem.9b01887
Alexander Neumann, Christa E. Müller, Vigneshwaran Namasivayam;
P2Y₁-like nucleotide receptors – Structures, molecular modeling, mutagenesis, and oligomerization.
WIREs Comput. Mol. Sci. 2020, 10, e1416; doi: 10.1002/wcms.1461
Alexander Neumann, Viktor Engel, Andhika B. Mahardhika, Clara T. Schoeder, Vigneshwaran Namasivayam, Katarzyna Kieć-Kononowicz, Christa E. Müller;
Computational investigations on the binding mode of ligands for the cannabinoid-activated G protein-coupled receptor GPR18.
Biomolecules 2020, 10, 686; doi: 10.3390/biom10050686
Younis Baqi, Mahmoud Rashed, Laura Schäkel, Enas M. Malik, Julie Pelletier, Jean Sévigny, Amelie Fiene, Christa E. Müller;
Development of anthraquinone derivatives as ectonucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors with selectivity for NTPDase2 and NTPDase3.
Front. Pharmacol. 2020, 11, 1-15; doi: 10.3389/fphar.2020.01282
Laura Schäkel, Constanze C. Schmies, Riham M. Idris, Xihuan Luo, Sang-Yong Lee, Vittoria Lopez, Salahuddin Mirza, The Hung Vu, Julie Pelletier, Jean Sévigny, Vigneshwaran Namasivayam, Christa E. Müller;
Nucleotide analog ARL67156 as a lead structure for the development of CD39 and dual CD39/CD73 ectonucleotidase inhibitors.
Front. Pharmacol. 2020, 11, 1-23; doi:10.33389/fphar.2020.01294
Markus Kuschak, Jonathan G. Schlegel, Marion Schneider, Stefan Kehraus, Jan H. Voss, Alexander Seidinger, Michaela Matthey, Daniela Wenzel, Bernd K. Fleischmann, Gabriele M. König, Christa E. Müller;
Sensitive LC-MS/MS method for the quantification of macrocyclic Gα_q protein inhibitors in biological samples.
Front. Chem. 2020, 8, 833; doi: 10.3389/fchem.2020.00833.eCollection2020
Constanze C. Schmies, Georg Rolshoven, Riham M. Idris, Karolina Losenkova, Christian Renn, Laura Schäkel, Haneen Al-Hroub, Yulu Wang, Francesca Garofano, Ingo G. H. Schmidt-Wolf, Herbert Zimmermann, Gennady G. Yegutkin, Christa E. Müller;
Fluorescent probes for ecto-5’-nucleotidase (CD73).
ACS Med. Chem. Lett. 2020, 11, 2253-2260; https://dx.doi.org.10.1021/acsmedchemlett.0c00391
Mariana Temido-Ferreira, Diana G. Ferreira, Vânia L. Batalha, Inês Marques-Morgado, Joana E. Coelho, Pedro Pereira, Rui Gomes, Andreia Pinto, Sara Carvalho, Paula M. Canas, Laetitia Cuvelier, Valerie Buée-Scherrer, Emilie Faivre, Younis Baqi, Christa E. Müller, José Pimentel, Serge N. Schiffmann, Luc Buée, Michael Bader, Tiago F. Outeiro, David Blum, Rodrigo A. Cunha, Hélène Marie, Paula A. Pousinha, Luísa V. Lopes;
Age-related shift in LPD is dependent on neuronal adenosine A_2A receptors interplay with mGluR5 and NMDA receptors.
Mol. Psychiatry 2020, 25, 1876-1900; https://doi.org/10.1038/s41380-018-0110-9
Clara T. Schoeder, Andhika B. Mahardhika, Anna Drabczyńska, Katarzyna Kieć-Kononowicz, Christa E. Müller;
Discovery of tricyclic xanthines as agonists of the cannabinoid-activated orphan G protein-coupled receptor GPR18.
ACS Med. Chem Lett. 2020, 11, 2024-2031; https://dx.doi.org/101021/acsmedchemlett.Oc00208
Maria P. Abbracchio, Kenneth A. Jacobson, Christa E. Müller, Herbert Zimmermann;
Professor Dr. Geoffrey Burnstock (1929-2020).
Purinergic Signal. 2020, 16, 137-149; https://doi.org/10.1007/s11302-020-09709-y
Kenneth A. Jacobson, Esmerilda G. Delicado, Christian Gachet, Charles Kennedy, Ivar von Kügelgen, Beibei Li, M. Teresa Miras-Portugal, Ivana Novak, Torsten Schöneberg, Raquel Perez-Sen, Doreen Thor, Beili Wu, Zhenlin Yang, Christa E. Müller;
Update of P2Y receptor pharmacology: IUPHAR Review 27.
Br. J. Pharmacol. 2020, 177, 2413-2433; doi: 10.1111/bph.15005
Carsten Hoffmann, Christa E. Müller, Herbert Zimmermann;
Obituary Geoff Burnstock (1929 – 2020).
Naunyn-Schmiedebergs Arch. Pharmacol. 2020, 393, 1773-1776; https://doi.org/10.1007/s00210-020-01937-8
Bastian Mähler, Kathrin Janssen, Martina Menneken, Mariam Tahoun, Markus Lagos, Gabriele Bierbaum, Christa E. Müller, Jes Rust;
Calcite precipitation forms crystal clusters and muscle mineralization during the decomposition of Cambarellus diminutus (Descapoda: Cambaridae) in freshwater.
Palaeontologia Electronica 2020, 23, a56; https://doi.org/10.26879/992palaeo-electronica/2020/2893-decomposing-crayfish
Theodore E. Liston, Sonja Hinz, Christa E. Müller, Debrorah M. Holstein, Jay Wendling, Roger J. Melton, Mary Campbell, William S. Korinek, R. Rama Suresh, Dane A. Sethre-Hofstad, Zhan-Guo Gao, Dilip K. Tosh, Kenneth A. Cacobson, James D. Lechleiter;
Nucleotide P2Y₁ receptor agonists are in vitro and in vivo prodrugs of A₁/A₃ adenosine receptor agonists: implications for roles of P2Y₁ and A₁/A₃ receptors in physiology and pathology.
Purinergic Signal. 2020, https://doi.org/10.1007/s11302-020-09732-z
Kenneth A. Jacobson, Adriaan P. IJzerman, Christa E. Müller;
Medicinal chemistry of P2 and adenosine receptors: Common scaffolds adapted for multiple targets.
Biochem. Pharmacol. 2020, 114311; https://doi.org/10.1016/j.bcp.2020.114311

2019

Molhm Nassir, Urid Arad, Sang-Yong Lee, Shani Yourno, Christian Renn, Herbert Zimmermann, Julie Pelletier, Jean Sévigny, Christa E. Müller, Bilha Fischer;
Identification of adenine-N9-(methoxy)ethyl-β-bisphosphonate as NPP1 inhibitors attenuates NPPase activity in human osteroarthritic chondrocytes.
Purinergic Sigal. 2019, 15, 247-263.
Michał Załuski, Jakub Schabikowski, Miriam Schlenk, Agnieszka Olejarz-Maciej,Bartłomiej Kubas, Tadeusz Karcz, Kamil Kuder, Gniewomir Latacz, Małgorzata Zygmunt,David Synak, Sonja Hinz, Christa E. Müller,Katarzyna Kieć-Kononowicz
Novel multi-target directed ligands based on annelated xanthine scaffold with aromatic substituents acting on adenosine receptor and monoamine oxidase B synthesis, in vitro and in silico studies.
Bioorg. Med. Chem, 2019, 27, 1195-1210.
Carina Lemke, Joscha Christmann, Jiafei Yin, José M. Alonso, Estefanía Serrano, Mourad Chioua, Lhassane Isaili, María Angeles Martínez-Grau, Christopher D. Beadle, Tatiana Vetman, Florian M. Dato, Ulrike Bartz, Paul W. Elsinhorst, Markus Pietsch, Christa E. Müller, Isabel Iriepa, Timo Wille, José Marco-Contelles, Michael Gütschow;
Chromenones as multineurotargeting inhibitors of human enzymes.
ACS Omega 2019, 4, 22161-22168.
Tobias Claff, Jing Yu, Véronique Blais, Nilkanth Patel, Charlotte Martin, Lijie Wu, Gye Won Han, Brien J. Holleran, Olivier Van der Poorten, Kate L. White, Michael A. Hanson, Philippe Sarret, Louis Gendron, Vadim Cherezov, Vsevolod Katritch, Steven Ballet, Zhi-Jie Liu, Christa E. Müller, Raymond C. Stevens;
Elucidating the active δ-opioid receptor crystal strucure with peptide and small-molecule agonists.
Sci. Adv. 2019, 5, eaax9115.
Astrid S. Obrecht, Nicole Urban, Michael Schaefer, Anni Röse, Achim Kless, Jannis E. Meents, Angelika Lampert, Aliaa Abdelrahman, Christa E. Müller, Günther Schmalzing, Ralf Hausmann;
Identification of aurintricarboxylic acid as a potent allosteric antagonist of P2X1 and P2X2 receptors.
Neuropharmacol. 2019, 158, 107749.
Sanjay Bhattarai, Jan Pippel, Anne Meyer, Marianne Freundlieb, Constanze Schmies, Aliaa Abdelrahman, Amelie Fiene, Sang-Yong Lee, Herbert Zimmermann, Ali E-Tayeb, Gennady G. Yegutkin, Norbert Sträter, Christa E. Müller;
X-ray co-crystal structure guedes the way to subnanomolar competitive ecto-5‘-nucleotidase (CD73) inhibitors for cancer immunotherapy.
Adv. Therap. 2019, 190075, 1-8.
Molhm Nassir, Salahuddin Mirza, Uri Arad, Sangyong Lee, Muhammad Rafehi, Isaac Yaw Attha, Christian Renn, Herbert Zimmermann, Julie Pelletier, Jean Sévigny, Christa E. Müller, Bilha Fischer;
Adenine-(methoxy)-ethoxy-P_α,α-dithio-triphosphate inhibits pathologic calcium pyrophosphate deposition in osteoarthritic human chondrocytes.
Org. Biomol. Chem. 2019, 17, 9913-9923.
Christa E. Müller;
Fortschritte in der Cannabis-Forschung aus pharmazeutische-chemischer Sicht.
Bundesgesundheitsblatt 2019, 62, 818-824.
Marvin Rausch, Julia Deisinger, Hannah Ulm, Anna Müller, Wenjin Li, Patrick Hardt, Marc Sylvester, Xiaogang Wang, Xue Li, Christa E. Müller, Marianne Engeser, Waldemar Vollmer, Hans-Georg Sahl, Jean Lee, Tanja Schneider;
Coordination of capsule assembly and cell wall biosynthesis in Staphylococcus aureus.
Nat. Commun. 2019, 10, 1-15; doi: 10.1038/s41467-019-09356-x.
Anna Junker, Christian Renn, Clemens Dobelmann, Vigneshwaran Namasivayam, Shanu Jain, Karolina Losenkova, Heikki Irjala, Sierra Duca, Ramachandran Balasubramanian, Saibal Chakraborty, Frederik Börgel, Herbert Zimmermann, Gennady Yegutkin, Christa E. Müller, Kenneth Jacobson;
Structure-activity relationship of purine and pyrimidine nucleotides as ecto-5'-nucleotidase (CD73) inhibitors.
J. Med. Chem. 2019, 62, 3677-3695.
Monica Armida, Alessandra Metteucci, Anotnella Pèzzola, Younis Baqi, Christa E. Müller, Patrizia Popoli, Rosa Lusia Potenza;
Modulating P1 adenosine receptors in disease progression of SOD1^G93A mutant mice.
Neurochem. Res. 2019, 44, 1037-1042.
Diego Dal Ben, Michela Buccioni, Catia Lambertucci, Gabriella Marucci, Andrea Spinaci, Anna Marchenkova, Aliaa Abdelrahman, Andrea Nistri, Christa E. Müller, Rosaria Volpini;
Investigation on 2’,3’-O-substituted ATP derviatives and analogs as novel P2X3 receptor antagonists.
ACS Med. Chem. Lett. 2019, 10, 493-498.
Daniel Marx, Gregor Schnakenburg, Stefan Grimme, Christa E. Müller;
Structural and conformational studies on carboxamides of 5,6-diaminouracils –percursors of biologically active xanthine derivatives.
Molecules 2019, 24, 1-16.
Francisco M. Mouro, Attila Köfalvi, Luís A. André, Younis Baqi, Christa E. Müller, Joaquim A. Ribeiro. Ana M. Sebastião;
Memory deficits induced by chronic cannabinoid exposure are prevented by adenosine A_2A receptor antagonism.
Neuropharmacol. 2019, 155, 10-21.
Jie Jiang, Catharina Julia Seel, Ahmed Temirak, Vigneshwaran Namasivayam, Antonella Arridu, Jakub Schabikowski, Younis Baqi, Sonja Hinz, Jörg Hockemeyer, Christa E. Müller;
A_2B Adenosine receptor antagonists with picomolar potency.
J. Med. Chem. 2019, 62, 4032-4055.
Younis Baqi, Christa E. Müller;
Antithrombotic P2Y12 receptor antagonists: Recent developments in drug discovery.
Drug Disc. Today 2019, 24, 325-333; doi.org/10.1016/J.drudis.2018.09.021.
Daniel Marx, Lukas M. Wingen, Gregor Schnakenburg, Christa E. Müller, Matthias S. Scholz;
Fast, efficient, and versatile synthesis of 6-amino-5-carboxamidouracils as precursors for 8-substituted xanthines.
Front. Chem. 2019, 7, 1-15; doi: 10.3389/fchem.2019.00056.
Paola Vaz, Carol Hartley, Sang-Yong Lee, Fiona Sansom, Timothy Adams, Kathryn Stalder, Lesley Pearce, George Lovrecz, Glenn Browing, Christa E. Müller, Joannne Devlin;
Koala and wombat gammaherpesviruses encode the first known viral nucleoside triphosphate diphosphohydrolase (NTPDase) homologs and are phylogenetically divergent from all known gammaherpesviruses.
J. Virol. 2019, 93, e01404-18.
Julian Zeiner, Sirpa Loukovaara, Karolina Losenkova, Mariachiara Zuccarini, Ani M. Korhonen, Kaisa Lehti, Anu Kauppinen, Kai Kaarniranta, Christa E. Müller, Sirpa Jalkanen, Gennady G Yegutkin;
Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous haemorrhage.
J. Mol. Chem. 2019,97, 341-354.

2018

Alberto Baroja-Mazo, Beatriz Revilla-Nuin, África de Bejar, Laura Martínez-Alarcón, José I. Herrero, Ali El-Tayeb, Christa E. Müller, Pedro Aparicio, Pablo Pelegrín, José A. Pons;
Extracellular adenosine reversibly inhibits the activation of human regulatory T cells and negatively influences the achievement of the operational tolerance in liver transplantation.
Am. J. Transplant. 2018, doi:10.111/ajt.15023.
Younis Baqi, Thanigaimalai Pillaiyar, Aliaa Abdelrahman, Olesja Kaufmann, Samer Alshaibani, Muhammad Rafeh, Saman Ghasimi, Rhalid Akkari, Kirsten Ritter, Katharina Simon, Andreas Spinraht, Evi Kostenis, Qiang Zhao, Meryem Köse, Vigneshwaran Namasivayam, Christa E. Müller;
3(-2Carboxyethyl)indole-2-carboxylic acid derivatives: structural requirements and properties of potent agonists of the orphan G protein-coupled receptor GPR17.
J. Med. Chem. 2018, doi: 1021/acs.jmedchem.7b01768.
Ali Haider, Kristof Zarschler, Sachin A. Joshi, Rachelle M. Smith, Zhengguo Lin,, Ali S. Mougharbel, Utta Herzog, Christa E. Müller, Holger Stephan, Ulrich Kortz;
Preyssler-Pope-Jeannin polyanion [NaP5W30O110]14- and [AgP5W30O110]14-: Microwave-assistde synthsis, structure, and biological activity.,
J. Inorg. Gen. Chem. 2018, doi: 10.1002/zaac.201800113
Emilie Faivre, Joana E. Coelho, Katja Zornbach, Enas Malik, Younis Baqi, Marion Schneider, Lucrezia Cellai, Kevin Carvalho, Shéhérazade Sebda, Martin Figeac, Sabiha Eddarkaoui, Raphaelle Caillierez, Yijuang Chern, Michael T Heneka, Nicolas Sergeant, Christa E. Müller, Annett Halle, Luc Buee, Luísa V. Lopes, David Blum;
Beneficial effect of a selective adenosine A2A receptor antagonist in the APPswe/PS1dE9 mouse model of Alzheimer’s Disease.
Frontiers Mol. Neurosci. 2018, 11, 1-13
Muhammad Rafehi, Christa E. Müller;
Tools and drugs for uracil nucleotide-activated P2Y receptors.
Pharmacol. Ther. 2018, 190, 24-80.
Pierre Koch, Andreas Brunschweiger, Vigneshwaran Namasivayam, Stefan Ullrich, Annalisa Maruca, Beatrice Lazzaretto, Petra Küppers, Sonja Hinz, Jörg Hockemeyer, Michael Wise, Jag Heer, Stefano Alcaro, Katarzyna Kieć-Kononowicz, Christa E. Müller;
Probing substituents in the 1- and 3-position: Tetrahydropyrazino-annelated water-soluble xanthine derivatives as multi-target drugs with potent adenosine receptor antagonistic activity.
Frontiers in Chemistry 2018, 6, 1- 28
Raphael Reher, Markus Kuschak, Nina Heycke, Suvi Annala, Stefan Kehraus, Hao-Fu Dai, Christa E. Müller, Evi Kostenis, Gabriele M. König, Max Crüsemann;
Applying Molecular Networking for the Detection of Natural Sources and Analogues of the Selective Gq Protein Inhibitor FR900359.
J. Nat. Prod. 2018, 81, 1628-1635.
Michał Załuski, Katarzyna Stanuch, Tadeusz Karcz, Sonja Hinz, TGenivowir Latacz, Ewa Szymańska, Jakub Schabikolwski Agata Doroż-Płonka, Jadwiga Handzlik, Anna Drabczyńska, Christa E. Müller, Katarzyna Kieć-Kononowicz;
Tricyclic xanthine derivatives containing a basic substituent: adenosine receptor affinity and drug-related properties.
MedChemComm. 2018, 9, 951-962.
Marcel Lindemann, Sonja Hinz, Winnie Deuther-Conrad, Vigneshwaran Namasivayam, Sladjana Dukic Stefanovic, Rodrigo Teodore, Magali Toussaint, Mathias Kranz, Cahtleen Juhl, Jörg Steinbach, Peter Brust, Christa E. Müller, Barbara Wenzel;
Radiosynthesis and in vivo evaluation of a fluorine-18 labeled pyrazine based radioligand for PET imaging of the adenosine A2B receptor.
Bioorg. Med. Chem. 2018, 26, 4650-4663.
Thanigaimalai Pillaiyar, Ewelina Gorska, Gregor Schnakenburg, Christa E. Müller;
General synthesis of unsymmetrical 3,3’-(Aza)diinolylmethane derivatives
J. Org. Chem. 2018, 83, 9902-9913.
Sonja Hinz, Wessam Alnouri, Ulrich Pleiss, Christa E. Müller;
Tritium-labeled agonists as tools for studying A2B receptors.
Purinergic Signal. 2018, 14, 223-233.
Clara T. Schoeder, Maria Kaleta, Andhika Mahardhika, Agnieszka Olejarz-Maciej, Dorota Łaźewska, Katarzyna Kieć-Kononowicz, Christa E. Müller;
Structure-activity relationships of imidazothiazinones and analogs as antagonists of the cannabinoid-activated orphan G protein-coupled receptor GPR18.
Eur. J. Med. Chem. 2018, 155, 381-397.
Meryem Köse, Sabrina Gollos, Tadeusz Karcz, Amelie Fiene, Fabian Heisig, Andrea Behrenswerth, Katarzyna Kieć-Kononowicz, Vigneshwaran Namasivayam, Christa E. Müller;
Fluorescent-labeled selective adenosine A2B receptor antagonist enables competition binding assay by flow cytometry.
J. Med. Chem. 2018, 61, 4301-4316
Clara Schoeder, Cornelius Hess, Burkhard Madea, Jens Meiler, Christa E. Müller;
Pharmacological evaluation of new constituents of “Spice”: synthetic cannabinoids based on indole, indazole, benzimidazole and carbazole scaffolds.
Forensic Toxicol. 2018, 36, 385-403.
Ulrich Gergs, Daniel Rothkirch, Britt Hofmann, Hendrik Treede, Bernard Robaye, Andreas Simm, Christa E. Müller, Joachim Neumann;
Mechanism underlying the contractile activity of UTP in the mammalian.
Eur. J. Pharmacol. 2018, 830, 47-58.
Daniel Poppe, Jonas Doerr, Marion Schneider, Ruven Wilkens, Julius A. Steinbeck, Julia Ladewig, Allison Tam, David E. Paschon, Philip D. Gregory, Andreas Reik, Christa E. Müller, Philipp Koch, Oliver Brüstle;
Genome editing in neuroepthelial stem cells to generat human neurons with high adenosine-releasing capacity.
Stem Cells Transl. Med. 2018, 7, 477-485.
Thanigaimalai Pillaiyar, Muhammad Dawood, Hina Irum, Christa E. Müller;
A rapid, efficient and versatile green synthesis of 3,3’-diindolylmethanes.
Arkivoc 2018, doi: https://doi.org/10.24820/ark.5550190.p010.259.
Seung-Hwa Kwak, Seungheon Shin, Ji-Hyun Lee, Kin-Kyoung Shim, Minjeong Kim, So-Deok Lee, Aram Lee, Jinsu Bae, Jin-Hee Park, Aliaa Abdelrah,an, Christa E. Müller, Steve K. Cho, Seok-Gu Kang, Myungt Ae Bae, Jung Yoon Yang, Hyojin Ko, William A. Goddard III, Youn-Chul Kim;
Synthesis and structure-activity relationships of quinolinone and quinoline-based P2X7 receptor antagonists and their anti-sphere formation activities in glioblastoma cells.
Eur. J. Med. Chem. 2018, 151, 462-481.
Thanigaimalai Pillaiyar, Meryem Köse, Vigneshwaran Namasivayam, Katharina; Sylvester, Gleice Borges, Dominik Thimm; Ivar von Kügelgen, Christa E. Müller;
6-(Ar)Alkylamino-substituted uracil derivatives: Lipid mimetics with potent activity at the orphan G protein-coupled receptor 84 (GPR84).
ACS Omega 2018, 3, 3357-3364.
Luca Antonioli, Ali El-Tayeb, Carolina Pellegrini, Matteo Fornai, O. Awwad, G. Giustarini, Gianfranco Natale, Larisa Ryskalin, Zoltán H. Németh, Christa E. Müller, Corrado Blandizzi, Rocchina Colucci;
Anti-inflammatory effect of a novel locally acting A2A receptor agonist in a rat model of oxazolone-induced colitis.
Purinergic Signal. 2018, 14, 27-36.
Sonja Hinz, Gemma Navarro, Dasiel Barroto-Escuela, Benjamin F. Seibt, York-Christoph Ammon, Elisabetta de Filippo, Azeem Danish, Svenja K. Lacher, Barbora Cervinková, Muhammad Rafehi, Kjell Fuxe, Anke C. Schiedel, Rafael Franco, Christa E. Müller;
Adenosine A2A receptor ligand recognition and signaling is blocked by A2B receptors.
Oncotarget 2018, 9, 13593-13611.
Dasiel O. Borroto-Escuela, Sonja Hinz, Gemma Navarro, Rafael Franco, Christa E. Müller, Kjell Fuxe;
Understanding the role of adenosine A2 AR heteroreceptor complexes in neurodegeneration and neuroinflammation.
Front. Neurosci. 2018, 12, 1-11, doi: 10.3389/fnins.2018.00043.
Max Crüsemann, Raphael Reher, Isabella Schamani, Alexander O. Brachmann, Tsubasa Ohbayashi, Markus Kuschak, Davide Malfacini, Alexander Seidinger, Marta Pinto-Carbó, René Richarz, Tatjana Reuter, Stefan Kehraus, Asis Hallab, Misty Attwood, Helgi B. Schiöth, Peter Mergaert, Yoshimoto Kikuchi, Till F. Schäberle, Evi Kostenis, Daniela Wenzel, Christa E. Müller, Jörn Piel Aurélien Carlier, Leo Eberl, Gabriele M. König;
Heterologous expression, biosynthetic studies, and ecological function of the selective Gq-signaling inhibitor FR900359.
Angew. Chem. Int. Ed. 2018, 57, 836-840.
Willem Jespers, Anke C. Schiedel, Laura H. Heitmann, Robert M. Cooke, Lisa Kleene, Gerard J. P. van Westen, David E. Gloriam, Christa E. Müller, Eddy Sotelo, Hugo Guitiérrez-de-Serán;
Structural mapping of adenosine receptor mutations: lingand binding and signaling mechanisms.
Trends Pharmacol. Sci. 2018, 39, 75-89.
Toru Hosoi, Shinsuke Ino, Fumie Ohnishi, Kenichi Todoroki, Michiko Yoshii, Mai Kaimoto, Christa E. Müller, Koichiro Ozawa;
Mechanisms of the action of adenine on anti-allergic effects in mast cells.
Immunity, Inflammation and Disease 2018, 6, 97-105. doi: 10.1002/iid3.200.
Eduardo Fuentes, Manuel Fuentes, Julio Caballero, Iván Palomo, Sonja Hinz, Ali El-Tayeb, Christa E. Müller;
Adenosine A2A receptor agonists with potent antiplatelet activity.
Platelets 2018, 29, 292-300. doi: 10.1080/09537104.2017.1306043

2017

Vigneshwaran Namasivayam, Sang-Yong Lee, Christa E. Müller;
The promiscuous ectonucleotidase NPP1: molecular insights into substrate binding and hydrolysis.
Biochim. Biophys. Acta 2017, 1861, 603-614.
Azeem Danish, Vigneshwaran Namasivayam, Anke C. Schiedel, Christa E. Müller;
Interaction of Approved Drugs with Synaptic Vesicle Protein 2A.
Arch. Pharm. 2017, 350, e1700003. doi: 10.1002/ardp.201700003.
Sang-Yong Lee, Soumya Sarkar, Sanjay Bhattarai, Vigneshwaran Namasivayam, Steven de Jonghe, Holger Stephan, Piet Herdewijn, Ali El-Tayeb, Christa E. Müller;
Substrate-dependence of competitive nucleotide pyrophosphatase/phosphodiesterase1 (NPP1) inhibitors.
Front. Pharmacol. 2017, 8: 1-15. doi: 10.3389/fphar.2017.00054.
Francisco M. Mouro, Vânia L. Batalha, Diana G. Ferreira, Joana E. Coelho, Younis Baqi, Christa E. Müller, Luísa V. Lopes, Joaquim A. Ribeiro, Ana M. Sebastião;
Chronic and acute adenosine A_2A receptor blockade prevents long-term episodic memory disruption caused by acute cannabinoid CB1 receptor activation.
Neuropharmacol. 2017, 117, 316-327.
Christa E. Müller, Domink Thimm, Karl-Heinz Baringhaus;
The 2016 Frontiers in Medicinal Chemistry in Bonn.
ChemMedChem 2017, 12, 100-103.
Muhammad Rafehi, Joachim C. Burbiel, Isaac Y. Attah, Aliaa Abdelrahman, Christa E. Müller;
Synthesis, characterization, and in vitro evaluation of the selective P2Y₂ receptor antagonist AR-C118925.
Purinergic Signal. 2017, 13, 89-103.
Ramasri Sathanoori, Paulina Bryl-Gorecka, Christa E. Müller, Laurie Erb, Gary A. Weisman, Björn Olde, David Erlinge.
P2Y₂ receptor modulates shear stress-induced cell alignment and actin stress fibers in human umbilical vein endothelial cells.
Cell. Mol. Life Sci. 2017, 74, 731-746.

Yue Zhang, János Peti-Peterdi, Anna U. Brandes, Anne Riquier-Brison, Noel G. Carlson, Christa E. Müller, Carolyn M. Ecelbarger, Bellamkonda K. Kishore;
Prasugrel suppresses development of lithium-induced nephrogenic diabetes insipidus in mice.
Purinergic Signal. 2017, 13, 239-248.
Aliaa Abdelrahman, Vigneshwaran Namasivayam, Sonja Hinz, Anke C. Schiedel, Meryem Köse, Maggi Burton, Ali El-Tayeb, Michel Gillard, Jürgen Bajorath, Marc de Ryck, Christa E. Müller;
Characterization of P2X4 receptor agonists and antagonists by calcium influx and radioligand binding studies.
Biochem. Pharmacol. 2017, 125, 41-54.
Muhammad Rafehi, Enas Malik, Alexander Neumann, Aliaa Abdelrahman, Theodor Hanck, Vigneshwaran Namasivayam, Christa E. Müller, Younis Baqi;
Development of potent and selective antagonists for the UTP-avtivated P2Y4 receptor.
J. Med. Chem. 2017, 60, 3020-3038.
Azeem Danish, Sang-Yong Lee, Christa E. Müller;
Quantification of green fluorescent protein-(GFP-)tagged membrane proteins by capillary gel electrophoresis.
Analyst 2017, 142, 3648-3655.
Raquel Boia, Filipe Elvas, Maria H. Madeira, Inês D. Aires, Ana C. Rodrigues-Neves, Pedro Tralhão, Eszter S. Szabó, Younis Baqi, Christa E. Müller, Ângelo R, Tomé, Rodrigo A. Cunha, and Antonio F. Ambrósio, Ana R. Santiago;
Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage.
Cell Death Dis. 2017, 8, e3065.
Jasmina Wiemann, Tzu-Ruei Yan, Philipp N. Sander, Marion Schneider, Marianne Engeser, Stephanie Kath-Schorr, Christa E. Müller, P. Martin Sander;
Dinosaur origin of egg color: oviraptors laid blue-green eggs.
PeerJ. 2017, 5, e3706; doi 10.7717/peerj3706.
Marta Cellorio, Estefanía Rojo-Bustamante, Diana Fernández-Suárez, Elena Sáez, Ander Estella-Hermoso de Mendoza, Christa E. Müller, María J. Ramírez, Julen Oyarzábal, Rafael Franco, María S. Aymerich;
GPR55: A therapeutic target for Parkinson’s disease?
Neuropharmacol. 2017, 125, 319-332.
Thanigaimalai Pillaiyar, Meryem Köse, Katharina Sylvester, Heike Weighardt, Dominik Thimm, Gleice Borges, Irmgard Förster, Ivar von Kügelgen, Christa E. Müller;
Diindolylmethane derivatives: potent agonists of the immunostimulatory orphan G protein-coupled receptor GPR84.
J. Med. Chem. 2017, 60, 3636-3655.
Kai Fredriksson, Philip Lottmann, Sonja Hinz, Iounut Onila, Aliaksei Shymanets, Christian Harteneck, Christa E. Müller, Christian Griesinger, Thomas E. Exner;
Nanodiscs for INPHARMA NMR characterization of GPCRs: ligand binding to the human A_2A adenosine receptor.
Angew. Chemie Int. Ed. Engl. 2017, 51, 5750-5754.
Paulo A. de Oliveira, James A. R. Dalton, Marc López-Cano, Adrià Ricarte, Xavier Morató, Filipe C. Matheus, Andréia S. Cunha, Christa E. Müller, Reinaldo N. Takahashi, Víctor Fernández-Dueñas, Jesús Giraldo, Rui D. Prediger, Francisco Ciruela;
Angiotensin II type 1/adenosine A2A receptor oligomers: a novel target for tardive dyskinesia.
Nature Scientific Rep. 2017, 7, 1857; doi:10.1038/s41598-017-02037-z.
Linda Feldbrügge, Alan C. Moss, Eric U. Yee, Eva Csizmadia, Shuji Mitsuhashi, Maria Serena Longhi, Bynvant Sandhu, Holger Stephan, Yan Wu, Adam S. Cheifetz, Christa E. Müller, Jean Sévigny, Simon C. Robson, Z. Gordon Jiang;
Expression of ecto-nucleoside triphosphate diphosphohydrolases-2 and -3 in the enteric nervous system affects inflammation in experimental colitis and Crohn’s disease.
J. Crohns Colitis 2017, 11, 1113-1123.
Michaela Matthey, Richard Roberts, Alexander Seilinger, Annika Simon, Ralf Schröder, Markus Kuschak, Suvi Annaly, Gabriele M. König, Christa E. Müller, Ian P. Hall, Evi Kostenis, Bernd K. Fleischmann, Daniela Wenzel;
Targeted inhibition of Gq signaling induces airway relaxation in mouse models of Asthma.
Sci. Transl. Med. 2017, 9, eaag2288; doi: 10.1126/scitranslmed.aag2288.
Sang-Yong Lee, Christa E. Müller;
Nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) and its inhibitors.
MedChemComm 2017, doi: 10.1039/c7md00015d.j.
Katinka Bekö, Bence Koványi, Flóra Gölöncsér, Gergely Horváth, Ádám Dénes, Zsuzsanna Környei, Bálint Botz, Zsuzsanna Helyes, Christa. E. Müller, Beata Sperlágh;
Contribution of platelet P2Y12 receptors to chronic complete Freund's adjuvant-induced inflammatory pain.
J. Thrombosis Haemostasis 2017, doi: 10.1111/jth.13684.
Muhammad Rafehi, Alexander Neumann, Younis Baqi, Enas M. Malik, Michael Wiese, Vigneshwaran Namasivayam, Christa E. Müller;
Molecular recognition of agonists and antagonists by the nucleotide-activated G protein-coupled P2Y2 receptor.
J. Med. Chem. 2017, 60, 8425-8440. doi: 10.1021/acs.jmedchem.7b00854.
Markus Schneider, Kirsten Prudic, Anja Pippel, Manuela Klapperstück, Ursula Braam, Christa E. Müller, Günther Schmalzing, Fritz Markwardt;
Interaction of purinergic P2X4 and P2X7 receptor subunits.
Front. Pharmacol. 2017, 8, 1–14; doi: 10.3389/fphar.2017.00860.
Verena Angerer, Lukas Mogler, Jan-Patrick Steitz, Philippe Bisel, Cornelius Hess, Clara Schoeder, Christa E. Müller, Laura Huppertz, Folker Westphal, Jan Schäper, Volker Auwärter;
Structural characterization and pharmacological evaluation of the new synthetic cannabinoid CUMYL-PEGACLONE.
Drug Test. Anal. 2017, doi: 10.1002/dta.2237.

2016

Enas M. Malik, Mahmoud Rashed, Lukas Wingen, Younis Baqi, Christa E. Müller;
Ullmann reactions of 1-amino-4-bromoanthraquinones bearing various 2-substituents furinishing novel dyes.
Dyes and Pigments 2016, 131, 33-40
Kenneth A. Jacobson, Christa E. Müller;
Medicinal chemistry of adenosine, P2Y and P2X receptors.
Neuropharmacol. 2016, 104, 31-49.
Cornelius Hess, Clara T. Schoeder, Thanigaimalai Pillaiyar, Burkhard Madea, Christa E. Müller;
Pharmacological evaluation of synthesis cannabinoids identified as constituents of spice.
Forensic Toxicol. 2016, 34, 329-343.
Sang-Yong Lee, Arianna Perotti, Steven De Jonghe, Piet Herdewijn, Theodor Hanck, Christa E. Müller;
Thiazolo[3,2-a]benzimidazol-3(2H)-one derivatives: structure-activity relationships of selective nucleotide pyrophosphatase/phosphodiesterase1 (NPP1) Inhibitors.
Bioorg. Med. Chem. 2016, 24, 3157-3165.
Elisabetta De Filippo, Vigneshwaran Namasivayam, Lukas Zappe, Ali El-Tayeb, Anke C. Schiedel, and Christa E. Müller;
Role of extracellular cysteine residues in the adenosine A_2A receptor.
Purinergic Signal. 2016, 12, 313-329.
Paul A. Mann, Anna Müller, Kerstin A. Wolff, Thierry Fischmann, Hao Wang, Patricia Reed, Yan Hou, Wenjin Li, Christa E. Müller, Jianying Xiao, Nicholas Murgolo, Xinwei Sher, Todd Mayhood, Payal R. Sheth, Asra Mirza, Marc Labroli, Li Xiao, Mark McCoy, Charles J. Gill, Mariana G. Pinho, Tanja Schneider, Terry Romer;
Chemical genetic analysis and functional characterization of staphylococcal wall teichoic acid 2-epimerases reveals unconventional antibiotic drug Targets.
PLoS Pathog. 2016, 12(5), e1005585.
Samantha J. Podurgiel, Tiahna Spencer, Rotem Kovner, Younis Baqi, Christa E. Müller, Merce Correa, John D. Salamone;
Induction of oral tremor in mice by the acetylcholinesterase inhibitor galantamine: reversal with adenosine A_2A antagonism.
Pharmacol. Biochem. Behav. 2016, 140, 62-67.
Cyril Laurent, Sylvie Burnouf, B. Ferry, Vânia L. Batalha, Joana E. Coelho, Younis Baqi, Enas Malik, Elodie Marciniak, S. Parrot, Ann Van der Jeugd, E. Faivre, V. Flaten, Catherine Ledent, Rudi D’Hooge, Nicolas Sergeant, Malika Hamdane, Sandrine Humez, Christa E. Müller, Luisa V. Lopes, Luc Buée, David Blum;
A_2A adenosine receptor deletion is protective in a mouse model of tauopathy.
Mol. Psychiatry 2016, 21, 97-107.
Vânia L. Batalha, Diana G. Ferreira, Joana E. Coelho, Jorge S. Valadas, Rui Gomes, Mariana Temido-Ferreira, Tatiana Shmidt, Younis Baqi, Luc Buée, Christa E. Müller, Malika Hamdane, Tiago F. Outeiro, Michael Bader, Sebastiaan H. Meijsing, Ghazaleh Sadri-Vakili, David Blum, Luisa V. Lopes;
The caffeine-binding adenosine A_2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function.
Nat. Sci. Rep. 2016, 6: 31493, doi: 10.1038/srep313493.
Amelie Fiene, Younis Baqi, Enas M. Malik, Patrice Newton, Wenjin Li, Sangyong Lee, Elizabeth L. Hartland, Christa E. Müller;
Inhibitors for the bacterial Ectonucleotidase Lp1NTPDase from Legionella pneumophila.
Bioorg. Med. Chem. 2016, 24, 4363-4371.
Caroline Flegel, Felix Vogel, Adrian Hofreuter, Sebastian Wojcik, Clara Schoeder, Katarzyna Kieć-Kononowicz, Norbert H. Brockmeyer, Christa E. Müller, Christian Becker, Janine Altmüller, Hanns Hatt, Günter Gisselmann;
Characterization of non-olfactory GPCRs in human sperm with a foucs on GPR18.
Nat. Sci. Rep. 2016, 6: 32255, doi: 10.1038/srep32255.
Laura López-Cruz, Noemi Dan-Miguel, Pilar Bayarri, Younis Baqi, Christa E. Müller, John D. Salamone, Mercé Correa;
Ethanol and caffeine effects on social interaction and recoginition in mice; involvement of adenosine A_2A and A₁ Receptors.
Front. Behav. Neurosci. 2016, 10, 1-15.
Andreas Brunschweiger, Pierre Koch, Miriam Schlenk, Muhammad Rafehi, Hamid Radjainia, Petra Küppers, Sonja Hinz, Felipe Pineda, Michael Wiese, Jörg Hockemeyer, Jag Heer, Frédéric Denonne, Christa E. Müller;
8-Substituted 1,3-dimethyltetrahydropyrazino[2,1-f]purinediones: Water-soluble adenosine receptor antagonists and monoamine oxidase B inhibitors.
Bioorg. Med. Chem. 2016, 24, 5462-5480.
Jin-Hee Park, Darren R. Williams, Ji-Hyung Lee, So-Deok Lee, Je-Heon Lee, Hyojin Ko, Ga-Eun Lee, Sujin Kim, Jeong-Min Lee, Aliaa Abdelrahman, Christa E. Müller, Da-Woon Jung, Yong-Chul Kim;
Potent suppressive effects of 1-piperidinylimidaole based novel P2X7 receptor antagonists on cancer cell migration and Invasion.
J. Med. Chem. 2016, 59, 7410-7430.
Joachim C. Burbiel, Wadih Ghattas, Petra Küppers, Meryem Köse, Svenja Lacher, Anna-Maria Herzner, Rajan Subramanian Kombu, Raghuram Rao Akkinepally, Jörg Hockemeyer, Christa E. Müller;
2-Amino[1,2,4]triazolo[1,5-c]quinazolines and derived novel heterocycles: Synthesis and struct
re-activity relationships of potent adenosine receptor antagonists.
ChemMedChem 2016, 11, 2272-2286.
Enas M. Malik, Christa E. Müller;
Anthraquinones as Pharmacological Tools and Drugs.
Med. Res. Rev. 2016, 36, 705-748.

2015 - 2011

2015

Ramona Schrage, Anna-Lena Schmitz, Evelyn Gaffal, Suvi Annala, Stefan Kehraus, Daniela Wenzel, Katrin M. Büllesbach, Tobias Bald, Asuka Inoue, Yuji Shinjo, Ségolène Galandrin, Naveen Shridhar, Michael Hesse, Manuel Grundmann, Nicole Merten, Thomas H. Charpentier, Matthew Martz, Adrian J. Butcher, Tanja Slodczyk, Sylvain Armando, Maike Effern, Yoon Namkung, Laura Jenkins, Velten Horn, Anne Stößel, Harald Dargatz, Daniel Tietze, Diana Imhof, Céline Galés, Christel Drewke, Christa E. Müller, Michael Hölzel, Graeme Milligan, Andrew B. Tobin, Jesús Gomeza, Henrik G. Dohlman, John Sondek, T. Kendall Harden, Michel Bouvier, Stéphane A. Laporte, Junken Aoki, Bernd K. Fleischmann, Klaus Mohr, Gabriele M. König, Thomas Tüting, Evi Kostenis;
The experimental power of FR900359 to study Gq-regulated biological processes.
Nat. Commun. 2015, 6: 10156, doi:10.1038/ncomms10156.

Enas M. Malik, Younis Baqi, Christa E. Müller;
Syntheses of 2-substituted 1-amino-4-bromoanthraquinones (bromaminic acid analogues) – precursors for dyes and drugs.
Beilstein J. Org. Chem. 2015, 11, 2326-2333.
Christa E. Müller;
Adenosine A_2A receptor antagonists in Drug Development.
The Adenosinergic System – A Non-Dopaminergic Target in Parkinson’s Disease
by Micaela Morelli, Nicola Simola, Jadwiga Wardas (Eds); Current Topics in Neurotoxicity, Vol. 10, Springer Verlag, 2015.
Sanjay Bhattarai, Marianne Freundlieb, Jan Pippel, Anne Meyer, Aliaa Abdelrahman, Amelie Fiene, Sang-Yong Lee, Herbert Zimmerman, Gennady G. Yegutkin, Norbert Sträter, Ali El-Tayeb, Christa E. Müller;
Methylene-ADP (AOPCP) derivatives and analogues: development of potent and selective ecto-5'-nucleotidase (CD73) inhibitors.
J. Med. Chem. 2015, 58, 6248-6263.

Silvia Paoletta, Davide Sabbadin, Ivar von Kügelgen, Sonja Hinz, Vsevolod Katritch, Kristina Hoffmann, Aliaa Abdelrahman, Jens Straßburger, Younis Baqi, Qiang Zhao, Raymond C. Stevens, Stefano Moro, Christa E. Müller, Kenneth A. Jacobson;
Modeling ligand recognition at the P2Y₁₂ receptor in light of X-ray structural information.
J. Comput.-Aided Mol. Des. 2015, 29, 737-756.
Marie-Therese Fuzzati-Armentero, Silvia Cerri, Giovanna Levandis, Giulia Ambrosi, Elena Montepeloso, Ginafilippg Antoninetti, Fabio Blandini, Younis Baqi, Christa E. Müller, Rosario Volpini, Giulia Costa, Nicola Simola, Annalisa Pinna;
Dual target strategy: combining distinct non-dopaminergic Treatments reduces neuronal cell loss and synergistically modulates L-DOPA-induced rotational behavior in a rodent model of Parkinson's disease.
J. Neurochem. 2015, 134, 740-747.

Mamona Nazir, Henrik Harms, Irene Loef, Stefan Kerhaus, Fayrouz El Maddah, Idris Arslan, Viktor Rempel, Christa E. Müller, Gabriele M. König;
GPR18 inhibiting amauromine and the novel triterpene glycoside auxarthonoside from the sponge-derived fungus Auxarthron reticulatum.
Planta Med. 2015, 81, 1141-1145.
Bellamkonda K. Kishore, Noel G. Carlosin, Carolyn M. Ecelbarger, D. E. Kohan, Christa E. Müller, R. D. Nelson, János Peti-Peterdi, Yue Zhang;
Targeting renal purinergic signalling for the treatment of lithium-induced nephrogenic diabetes insipitus.
Acta Physiol. 2015, 214, 176-188.
Jasmin Wiemann, Tzu-Ruei Yang, Philipp N. Sander, Marion Schneider, Marianne Engeser, Stephanie Kath-Schorr, Christa E. Müller, P. Martin Sander;
The blue-green eggs of dinosaurs: How fossil metabolites provide insights into the evolution of bird reproduction.
PeerJ PrePrints 2015, 3:e1323; https://dx.doi.org/10.7278/peerj.preprints.1080.

Amelie Fiene, Younis Baqi, Joanna Lecka, Jean Sévigny, Christa E. Müller;
Fluorescence polarization immunoassays for monitoring nucleoside triphosphatediphosphohydrolase (NTPDase) activity.
Analyst 2015, 140, 140-148.
Sangyong Lee, Amelie Fiene, Wenjin Li, Theodor Hanck, Konstantin A. Brylev, Vladimir E. Fedorov, Joanna Lecka, Ali Haider, Hans-Jürgen Pietzsch, Herbert Zimmermann, Jean Sévigny, Ulrich Kortz, Holger Stephan, Christa E. Müller;
Polyoxometalates - Potent and selective ecto-nucleotidase inhibitors.
Biochem. Pharmacol. 2015, 93, 171–181.
Christa E. Müller;
Medicinal chemistry of P2X receptors: Allosteric modulators.
Curr. Med. Chem. 2015, 22, 929-941.
Ramasri Sathanoori, Federica Rosi, B. J. Gu, James S. Wiley, Christa E. Müller, Björn Olde, David Erlinge;
Shear stress modulates endothelial KLF2 through activiation of P2X4.
Purinergic Signal. 2015, 11, 139-153.
Samantha E. Yohn, Christian Thompson, Patrick A. Randall, Christie A. Lee, Christa E. Müller, Younis Baqi, Mercè Correa, John D. Salamone;
The VMAT-2 inhibitor tetrabenazine alters effort-related decision making as measured by the T-maze barrier choice task: reversal with the adenosine A_2A antagonist MSX-3 and the catecholamine uptake blocker bupropion.
Psychopharmacol. 2015, 232, 1313-1323.
Manuella P. Kaster, Nuno J. Machado, Henrique B. Silva, Ana Nunes, Ana Paula Ardais, Magda Santana, Younis Baqi, Christa E. Müller, Ana Lúcia S. Rodrigues, Lisiane O. Porciúncula, Jiang-Fan Chen, Ângelo R. Tomé, Paula M. Agostinho, Paula M. Canas, Rodrigo A. Cunha;
Caffeine acts through neuronal adenosine A_2A receptors to prevent mood and memory dysfunction triggered by chronic stress.
Proc. Natl. Acad. Sci. USA 2015, 112, 7833-7838.
Wei Li, Henrique B. Silva, Joana Real, Yu-Mei Wang, Daniel Rial, Ping Li, Marie-Pierce Payen, Yauanguo Zhou, Christa E. Müller, Angelo R. Tomé, Rodrigo A. Cunha, Jiang-Fan Chen;
Inactivation of adenosine A_2A receptors reverses working memory deficits at early stages of Huntington’s disease models.
Neurobiol. Disease 2015, 79, 70-80.
Wenjin Li, Isabell Zech, Volkmar Gieselmann, Christa E. Müller;
A capillary electrophoresis method with dynamic pH junction stacking for the monitoring of cerebroside sulfotransferase.
J. Chromatogr. A 2015, 1407, 222-227.
Dominik Thimm, Anke C. Schiedel, János Peti-Peterdi, Bellamkonda K. Kishore, Christa E. Müller;
The nucleobase adenine as a signalling molecule in the kidney.
Acta Physiol. 2015, 213, 808-818.
Yue Zhang, Janos Peti-Peterdi, Christa E. Müller, Noel G. Carlson, Younis Baqi, David L. Strasburg, Kristina M. Heiney, Karie Villaneuva, Donald E. Kohan, Bellamkonda K. Kishore;
P2Y₁₂ receptor localizes in the renal collecting duct and its blockade augments arginine vasopressin action and alleviates nephrogenic diabetes insipidus.
J. Am. Soc. Nephrol. 2015, 26, 2978-2987.
Mohamad Wessam Alnouri, Stephan Jepards, Alessandro Casari, Anke C. Schiedel, Sonja Hinz, Christa E. Müller;
Selectivity is species-dependent: Characterization of standard agonists and antagonists at human, rat, and mouse adenosine receptors.
Puringeric Sigal. 2015, 11, 389-407.

2014

Fabian Heisig, Sabrina Gollos, Sven J. Freudenthal, Ali El-Tayeb, Jamshed Iqbal, Christa E. Müller;
Synthesis of BODIPY derivatives substituted with various bioconjugatable linker groups: A construction kit for fluorescent labeling of receptor ligands.
J. Fluoresc. 2014, 24, 213-230.
Eric E. Nunes, Patrick A. Randall, Alexavier Estrada, Brian Epling, Evan H. Hart, Christie A. Lee, Younis Baqi, Christa E. Müller, Mercé Correa, John D. Salamone;
Effort-related motivational effects of the pro-inflammatory cytokine interleukin 1-beta: studies with the concurrent fixed ratio 5/ chow feeding choice task.
Psychopharmacol. 2014, 231, 726-737.
Maoqun Tian, Aliaa Abdelrahman, Stephanie Weinhausen, Sonja Hinz, Stefanie Weyer, Stefan Dosa, Ali El-Tayeb, Christa E. Müller;
Carbamazepine derivatives with P2X4 receptor-blocking activity.
Bioorg. Med. Chem. 2014, 22, 1077-1088.
Younis Baqi, Samer Alshaibani, Kirsten Ritter, Aliaa Abdelrahman, Andreas Spinrath, Evi Kostenis, Christa E. Müller;
Improved synthesis of 4-/6-substituted 2-carboxy-1H-indole-3-propionic acid derivatives and structure-activity relationships as GPR17 agonists.
Med. Chem. Commun. 2014, 5, 86-92.
Jordi Bonaventura, Alberto J. Rico, Estefanía Moreno, Salvador Sierra, Marta Sánchez, Natasha Luquin, Daniel Farré, Christa E. Müller, Eva Martínez-Pinilla, Antoni Cortés, Josefa Mallol, Marie-Therese Armentero, Annalisa Pinna, Enric I. Canela, Carme Lluís, Peter J. McCormick, José L. Lanciego, Vicent Casadó, Rafael Franco;
L-DOPA-treatment in primates disrupts the expression of A2A adenosine-CB1 cannabinoid-D2 dopamine receptor heteromers in the caudate nucleus.
Neuropharmacol. 2014, 79, 90-100.
Matthias Mertens, Sonja Hinz, Christa E. Müller, Michael Gütschow;
Alkynyl–coumarinyl ethers as MAO-B inhibitors.
Bioorg. Med. Chem. 2014, 22, 1916-1928.
Sang-Yong Lee, Christa E. Müller;
Large-volume sample stacking with polarity switching for monitoring of nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) reactions by capillary electrophoresis.
Electrophoresis 2014, 35, 855–863.
Viktor Rempel, Kerstin Atzler, Andrea Behrenswerth, Tadeusz Karcz, Clara Schoeder, Sonja Hinz, Maria Kaleta, Dominik Thimm, Katarzyna Kieć-Kononowicz, Christa E. Müller;
Bicyclic imidazole-4-one derivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 und GPR55.
Med. Chem. Commun. 2014, 5, 632-649.
Meryem Köse, Kirsten Ritter, Katharina Thiemke, Michel Gillard, Evi Kostenis, Christa E. Müller;
Development of [³H]2-carboxy-4,6-dichloro-1H-indole-3-propionic acid ([³H]PSB-12150): a useful tool for studying GPR17.
ACS Med. Chem. Lett. 2014, 5, 326-330.
Kaihua Zhang, Jin Zhang, Zhan-Guo Gao, Dandan Zhang, Lan Zhu, GyeWon Han, Steven M. Moss, Silvia Paoletta, Evgeny Kiselev, Weizhen Lu, Gustavo Fenalti, Wenru Zhang, Christa E. Müller, Huaiyu Yang, Hualiang Jiang, Vadim Cherezov, Vsevolod Katritch, Kenneth A. Jacobson, Raymond C. Stevens, Beili Wu, Qiang Zhao;
Structure of the human P2Y₁₂ receptor in complex with an antithrombotic drug.
Nature 2014, 509, 115-118.
Jin Zhang, Kaihua Zhang, Zhan-Guo Gao, Silvia Paoletta, Dandan Zhang, Gye Won Han, Tingting Li, Limin Ma, Wenru Zhang, Christa E. Müller, Huaiyu Yang, Hualiang Jiang, Vadim Cherezov, Vsevolod Katritch, Kenneth A. Jacobson, Raymond C. Stevens, Beili Wu, Qiang Zhao;
Agonist-bound structure of the human P2Y₁₂ receptor.
Nature 2014, 509, 119-122.
Henrik Harms, Viktor Rempel, Stefan Kehraus, Marcel Kaiser, Peter Hufendiek, Christa E. Müller, Gabriele M. König;
Indoloditerpenes from a marine-derived fungal strain of Dichotomomyces cejpii with antagonistic activity at GPCR18 and cannabinoid receptors.
J. Nat. Prod. 2014, 77, 673-677.
André Jerónimo-Santos, Vânia L. Batalha, Christa E. Müller, Younis Baqi, Ana Maria Sebastião, Luisa V. Lopes, Maria José Diógenes;
Impact of in vivo chronic blockade of adenosine A_2A receptors on the BDNF-mediated facilitation of LTP.
Neuropharmacol. 2014, 83, 99-106.
Gergely Horváth, Flóra Gölöncsér, Cecilia Csölle, Kornél Király, Rómeó D. Andó, Mária Baranyi, Bence Koványi, Zoltán Máté, Kristina Hoffmann, Irina Algaier, Younis Baqi, Christa E. Müller, Ivar Von Kügelgen, Beáta Sperlágh;
Central P2Y₁₂ receptor blockade alleviates inflammatory and neuropathic pain and cytokine production in rodents.
Neurobiol. Dis. 2014, 70, 162-178.
Patrick A. Randall, Christie A. Lee, Eric J. Nunes, Samantha E. Yohn, Victoria Nowak, Bilal Khan, Priya Shah, Saagar Pandit, V. Kiran Vemuri, Alex Makriyannis, Younis Baqi, Christa E. Müller, Merce Correa, John D. Salamone;
The VMAT-2 inhibitor tetrabenazine affects effort-related decision making in a progressive ratio/chow feeding choice task: reversal with antidepressant drugs.
PLoS one 2014, e99320.
Cyril Laurent, Sabiha Eddarkaoui, Maxime Derisbourg, Antoine Leboucher, Dominique Demeyer, Sébastien Carrier, Marion Schneider, Malika Hamdane, Christa E. Müller, Luc Buée, David Blum;
Beneficial effects of caffeine in a transgenic model of Alzheimer’s disease-like tau pathology.
Neurobiol. Aging 2014, 35, 2079-2090.
Sonja Hinz, Svenja K. Lacher, Benjamin F. Seibt, Christa E. Müller;
BAY60-6583 acts as a partial agonist at adenosine A_2B receptors.
J. Pharmacol. Exp. Ther. 2014, 349, 427–436.
Karin Önnheim, Karin Christenson, Michael Gabla, Joachim C. Burbiel, Christa E. Müller, Tudor I. Opreaa, Johan Bylund, Claes Dahlgren, Huamei Forsman;
A novel receptor cross-talk between the ATP receptor P2Y₂ and formyl peptide receptors reactivates desensitized neutrophils to produce superoxide.
Exp. Cell Res. 2014, 323, 209-217.
Matthias Zebisch, Younis Baqi, Petra Schäfer, Christa E. Müller, Norbert Sträter;
Crystal structure of NTPDase2 in complex with the sulfoanthraquinone inhibitor PSB-071.
J. Struct. Biol. 2014, 185, 336-341.
Andreas Brunschweiger, Pierre Koch, Miriam Schlenk, Felipe Pineda, Petra Küppers, Sonja Hinz, Meryem Köse, Stefan Ullrich, Jörg Hockemeyer, Michael Wiese, Jag Heer, Christa E. Müller;
8-Benzyltetrahydropyrazino[2,1-f]purinediones: water-soluble tricyclic xanthine derivatives as multitarget drugs for neurodegenerative diseases.
ChemMedChem 2014, 9, 1704–1724.
Nikolay T. Tzvetkov, Sonja Hinz, Petra Küppers, Marcus Gastreich, Christa E. Müller;
Indazole- and indole-5-carboxamides: selective and reversible monoamine oxidase B inhibitors with subnanomolar potency.
J. Med. Chem. 2014, 57, 6679−6703.
Silvia Cerri, Giovanna Levandis, Giulia Ambrosi, Elena Montepeloso, Gian Filippo Antoninetti, Rafael Franco, José Luis Lanciego, Younis Baqi, Christa E. Müller, Annalisa Pinna, Fabio Blandini, Marie Therese Armentero;
Neuroprotective potential of adenosine A_2A and cannabinoid CB₁ receptor antagonists in an animal model of Parkinson disease.
J. Neuropath. Exp. Neurol. 2014, 73, 414-424.
Wenjin Li, Hannah Ulm, Marvin Rausch, Xue Li, Katie O’Riordan, Jean C. Lee, Tanja Schneider, Christa E. Müller;
Analysis of the Staphylococcus aureus capsule biosynthesis pathway in vitro: Characterization of the UDP-GlcNAc C6 dehydratases CapD and CapE and identification of enzyme inhibitors.
Int. J. Med. Microbiol. 2014, 304, 958-969.
Alexander Fuchs, Roland Baur, Clara Schoeder, Erwin Sigel, Christa E. Müller;
Structural analogues of the natural products magnolol and honokiol as potent allosteric potentiators of GABA_A receptors.
Bioorg. Med. Chem. 2014, 22, 6908-6917.
Kristina Hoffmann, Dominique A. Lutz, Jens Straßburger, Younis Baqi, Christa E. Müller, Ivar von Kügelgen;
Competitive mode and site of interaction of ticagrelor at the human platelet P2Y₁₂ receptor.
J. Thromb. Haemost. 2014, 12, 1898-1905.
Holger Stephan, Martin Walther, Silke Fähnemann, Paola Ceroni, Jennifer K. Molloy, Giacomo Bergamini, Fabian Heisig, Christa E. Müller, Werner Kraus, Peter Comba;
Bispidines for Dual Imaging.
Chem. Eur. J. 2014, 20, 17011-17018.
Christa E. Müller, Anke C. Schiedel, Herbert Zimmermann;
Purines 2014: Nucleotides, nucleosides and nucleobases – international conference on signalling, drugs and targets.
Purinergic Signal. 2014, 10, 651-656.
Miriam C. Peeters, Qilan Li, Rachel Elands, Gerard J.P. van Westen, Eelke B. Lenselink, Christa E. Müller, Adriaan P. IJzerman;
Domains for activation and inactivation in G protein-coupled receptors – A mutational analysis of constitutive activity of the adenosine A_2B receptor.
Biochem. Pharmacol. 2014, 92, 348-357.
Yassine Sassi, Andrea Ahles, Dong-Jiunn Jeffery Truong, Younis Baqi, Sang-Yong Lee, Britta Husse, Jean-Sébastien Hulot, Ariana Foinquinos, Thomas Thum, Christa E. Müller, Andreas Dendorfer, Bernhard Laggerbauer, Stefan Engelhardt;
Cardiac myocyte–secreted cAMP exerts paracrine action via adenosine receptor activation.
J. Clin. Invest. 2014, 124, 5385-5397.
Lei Chang, Sang-Yong Lee, Piotr Leonczak, Jef Rozenski, Steven De Jonghe, Theodor Hanck, Christa E. Müller, Piet Herdewijn;
Imidazopyridine- and purine-thioacetamide derivatives: potent inhibitors of nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1).
J. Med. Chem. 2014, 57, 10080-10100.
Thorsten Gnad, Saskia Scheibler, Ivar von Kügelgen, Camilla Scheele, Ana Kilić, Anja Glöde, Linda S. Hoffmann, Laia Reverte-Salisa, Philipp Horn, Samet Mutlu, Ali El-Tayeb, Mathias Kranz, Winnie Deuther-Conrad, Peter Brust, Martin E. Lidell, Matthias J. Betz, Sven Enerbäck, Jürgen Schrader, Gennady G. Yegutkin, Christa E. Müller, Alexander Pfeifer;
Adenosine activates brown adipose tissue and recruits beige adipocytes via A_2A receptors.
Nature 2014, 516, 395-399.
Z. Gordon Jiang, Yan Wu, Eva Csizmadia, Linda Feldbrügge, Keiichi Enjyoji, John Tigges, Vasilis Toxavidis, Holger Stephan, Christa E. Müller, C. James McKnight, Alan Moss, Simon C. Robson;
Characterization of circulating microparticle-associated CD39 family ecto-nucleotidases in human plasma.
Purinergic Signal. 2014, 10, 611-618.
Marianne Freundlieb, Herbert Zimmermann, Christa E. Müller;
A new sensitive ecto-5‘-nucleotidase assay for compound screening.
Anal. Biochem. 2014, 446, 53-58.
Annalisa Pinna, Jordi Bonaventura, Daniel Farré, Marta Sánchesz, Nicola Simola, Josefa Mallol, Carme Lluís, Giulia Costa, Younis Baqi, Christa E. Müller, Antoni Cortés, Peter McCormick, Enric I. Canela, Eva Martínez-Pinilla, José L. Lanciego, Vicent Casadó, Marie-Therese Armentero, Rafael Franco;
L-DOPA disrupts adenosine A_2A-cannabinoid CB₁-dopamine D₂ receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: Biochemical and behavioral studies.
Exp. Neurol. 2014, 253, 180-191.
Cyril Laurent, Sylvie Burnouf, B. Ferry, Vânia L. Batalha, Joana E. Coelho, Younis Baqi, Enas Malik, Elodie Marciniak, S. Parrot, Ann Van der Jeugd, E. Faivre, V. Flaten, Catherine Ledent, Rudi D’Hooge, Nicolas Sergeant, Malika Hamdane, Sandrine Humez, Christa E. Müller, Luisa V. Lopes, Luc Buée, David Blum;
A_2A adenosine receptor deletion is protective in a mouse model of tauopathy.
Mol. Psychiatry 2014, 1-11.

2013

Vânia L. Batalha, José M. Pego, Bruno M. Fontinha, Ana R. Costenla, Jorge S. Valadas, Younis Baqi, Hamid Radjainia, Christa E. Müller, Ana M. Sebastião, Luisa V. Lopes;
Adenosine A_2A receptor blockade reverts hippocampal stress-induced deficits and restores corticosterone circadian oscillation.
Mol. Psych. 2013, 18, 320-331.
Philippe Ohlmann, Anna Lecchi, Ali El-Tayeb, Christa E. Müller, Marco Cattaneo, Christian Gachet;
The platelet P2Y₁₂ receptor under normal and pathological conditions. Assessment with the radiolabeled selective antagonist [³H]PSB-0413.
Purinergic Signal. 2013, 9, 59-66.
Benjamin F. Seibt, Anke C. Schiedel, Dominik Thimm, Sonja Hinz, Farag F. Sherbiny, Christa E. Müller;
The second extracellular loop of GPCRs determines subtype-selectivity and controls efficacy as evidenced by loop exchange study at A₂adenosine receptors.
Biochem. Pharmacol. 2013, 85, 1317-1329.
Jamshed Iqbal, Shoaib Iqbal, Christa E. Müller;
Advances in immobilized Enzyme microbioreactors in capillary electrophoresis.
Analyst 2013, 138, 3104-3116.
Anne Stößel, Miriam Schlenk, Sonja Hinz, Petra Küppers, Jag Heer, Michael Gütschow, Christa E. Müller;
Dual targeting of adenosine A_2A receptors and monoamine oxidase B by 4H-3,1-benzothiazin-4-ones.
J. Med. Chem. 2013, 56, 4580-4596.
Viktor Rempel, Nicole Volz, Franziska Gläser, Martin Nieger, Stefan Bräse, Christa E. Müller;
Antagonists for the orphan G-protein-coupled receptor GPR55 based on a coumarin scaffold.
J. Med. Chem. 2013, 56, 4798-4810.
Mario Funke, Dominik Thimm, Anke C. Schiedel, Christa E. Müller;
8-Benzamidchormen-4-one-2-carboxylic acids - potent and selective agonists for the orphan G protein-coupled receptor GPR35.
J. Med. Chem. 2013, 56, 5182-5197.
Dominik Thimm, Anke C. Schiedel, Farag F. Sherbiny, Sonja Hinz, Katharina Hochheiser, Daniela C.G. Bertarelli, Astrid Maaß, Christa E. Müller;
Ligand-specific binding and activation of the human adenosine A_2B receptor.
Biochemistry 2013, 52, 726-740.

Samantha J. Podurgiel, Eric J. Nunes, Samantha E. Yohn, James Barber, Alexis Thompson, Meredith Milligan, Christie A. Lee, Laura López-Cruz, Marta Pardo, Olga Valverde, Catherine Ledent, Younis Baqi, Christa E. Müller, Mercé Correa. John D. Salamone;
The vesicular monoamine transporter (vmat-2) inhibitor tetrabenazine induces tremulous jaw movements in rodents: implications for pharmacological models of parkinsonian tremor.
Neuroscience 2013, 250C, 507-519.
Elisabete Augusto, Marco Matos, Jean Sévigny, Ali El-Tayeb, Margaret S. Bynoe, Christa E. Müller, Rodrigo A. Cunha, and Jiang-Fan Chen;
Ecto-5′-nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A_2A receptor functions.
J. Neurosci. 2013, 33, 11390-11399.

Bellamkonda K. Kishore, Yue Zhang, Haykanush Gevorgyan, Donald E. Kohan, Anke C. Schiedel, Christa E. Müller, János Peti-Peterdi;
Cellular localization of adenine receptors in the rat kidney and their functional significance in the inner medullary collecting duct.
Am. J. Physiol. Renal. Physiol. 2013, 305, F1298–F1305.

Lyndsey E. Collins-Praino, Nicholas E. Paul, Felicia Ledgard, Samantha J. Podurgiel, Rotem Kovner, Younis Baqi, Christa E. Müller, Patrick B. Senatus, John D. Salamone;
Deep brain stimulation of the subthalamic nucleus reverses oral tremor in pharmacological models of parkinsonism: interaction with the effects of adenosine A_2A antagonism.
Eur. J. Neurosci. 2013, 38, 2183-2191.

Anna Drabczyńska, Tadeusz Karcz, Ewa Szymańska, Meryem Köse, Christa E. Müller, Minka Paskaleva, Janina Karola-Wojciechowsa, Jadwiga Handzlik, Olga Yuzlenko, Katarzyna Kieć-Kononowicz;
Synthesis, biological activity and molecular modelling studies of tricyclic alkylimidazo-, pyrimido- and diazepinopurinediones.
Purinergic Signal. 2013, 9, 395-414.

Carla G. Silva, Christine Métin, Walid Fazeli, Nuno J. Machado, Sanja Darmopil, Pierre-Serge Launay, Antoine Ghestem, Marie-Pascale Nesa, Emilie Bassot, Eszter Szabó, Younis Baqi, Christa E. Müller, Angelo R. Tomé, Anton Ivanov, Dirk Isbrandt, Yuri Zilberter, Rodrigo A. Cunha, Monique Esclapez, Christophe Bernard;
Adenosine receptor antagonists including caffeine alter fetal brain development in mice.
Sci. Transl. Med. 2013, 5, 197ra104.

Marta Pardo, Laura López-Cruz, Olga Valverde, Catherine Ledent, Younis Baqi, Christa E. Müller, John D. Salamone, Mercé Correa;
Effect of subtype-selective adenosine receptor antagonists on basal or haloperidol-regulated striatal function: studies of exploratory locomotion and c-Fos immunoreactivity in outbred and A_2A R KO mice.
Behav. Brain Res. 2013, 247, 217-226.
John D. Salamone, Lyndsey E. Collins-Praino, Marta Pardo, Samantha J. Podurgiel, Younis Baqi, Christa E. Müller, Michael A. Schwarzschild, Mercé Correa;
Conditional neural knockout of the adenosine A_2A receptor and pharmacological A_2A antagonism reduce pilocarpine-induced tremulous jaw movements: Studies with a mouse model of parkinsonian tremor.
Eur. Neuropsychopharmacol. 2013, 23, 972-977.
Holger Stephan, Manja Kubeil, Franziska Emmerling, Christa E. Müller;
Polyoxometalates as versatile enzyme inhibitors.
Eur. J. Inorg. Chem. 2013, 1585-1594.

Pierre Koch, Rhalid Akkari, Andreas Brunschweiger, Thomas Borrmann, Miriam Schlenk, Petra Küppers, Meryem Köse, Hamid Radjainia, Jörg Hockemeyer, Anna Drabczyńska, Katarzyna Kieć-Kononowicz, Christa E. Müller;
1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases.
Bioorg. Med. Chem. 2013, 21, 7435–7452.
Stephanie Hennen, Haibo Wang, Lucas Peters, Nicole Merten, Katharina Simon, Andreas Spinrath, Stefanie Blättermann, Rhalid Akkari, Ramona Schrage, Ralf Schröder, Daniel Schulz, Celine Vermeiren, Katrin Zimmermann, Stefan Kehraus, Christel Drewke, Alexander Pfeifer, Gabriele M. König, Klaus Mohr, Michel Gillard, Christa E. Müller, Q. Richard Lu, Jesús Gomeza, Evi Kostenis;
Decoding signaling and function of the orphan G protein-coupled receptor GPR17 with a small-molecule agonist.
Sci. Signal. 2013, 6, 1-16.
Melanie Knospe, Christa E. Müller, Patrizia Rosa, Aliaa Abdelrahman, Ivar von Kügelgen, Dominik Thimm, Anke C. Schiedel;
The rat adenine receptor: pharmacological characterization and mutagenesis studies to investigate its putative ligand binding site.
Purinergic Signal. 2013, 9, 367-381.
Dominik Thimm, Melanie Knospe, Aliaa Abdelrahman, Miguel Moutinho, Bernt B. A. Alsdorf, Ivar von Kügelgen, Anke C. Schiedel, Christa E. Müller;
Characterization of new G protein-coupled adenine receptors in mouse and hamster.
Purinergic Signal. 2013, 9, 415-426.
Edith Hochhauser, Ronit Cohen, Maayan Waldman, Anna Maksin, Ahuva Isak, Dan Aravot, P. Suresh Jayasekara, Christa E. Müller, Kenneth A. Jacobson, Asher Shainberg;
P2Y₂ receptor agonist with enhanced stability protects the heart from ischemic damage in vitro and in vivo.
Purinergic Signal. 2013, 9, 633-642.
Alexander Fuchs, Victor Rempel, Christa E. Müller;
The natural structure magnolol as a lead structure for the development of potent cannabinoid receptor agonists.
PLOS one 2013, 8, e77739.
Eric J. Nunes, Patrick A. Randall, Evan E. Hart, Charlotte Freeland, Samantha E. Yohn, Younis Baqi, Christa E. Müller, Laura López-Cruz, Mercé Correa, John D. Salamone;
Effort-related motivational effects of the VMAT-2 inhibitor tetrabenazine: implications for animal models of the motivational symptoms of depression.
J. Neurosci. 2013, 33, 19120-19130.
Anke C. Schiedel, Svenja Lacher, Carsten Linnemann, Percy A. Knolle, Christa E. Müller;
Antiproliferative effects of selective adenosine receptor agonists and antagonists on human lymphocytes: evidence for receptor-independent mechanisms.
Purinergic Signal. 2013, 9, 351-365.
Dominik Thimm, Mario Funke, Anne Meyer, Christa E. Müller;
6-Bromo-8-(4-[³H]methoxybenzamido)-4-oxo-4H-chromene-2-carboxylic acid: a powerful tool for studying orphan G protein-coupled receptor GPR35.
J. Med. Chem. 2013, DOI 10.1021/jm4009373.
Fabian Heisig, Sabrina Gollos, Sven J. Freudenthal, Ali El-Tayeb, Jamshed Iqbal, Christa E. Müller;
Synthesis of BODIPY derivatives substituted with various bioconjugatable linker groups: A construction kit for fluorescent labeling of receptor ligands.
J. Fluoresc. 2013, 23, DOI 10.1007/s10895-013-1289-4.
Eric E. Nunes, Patrick A. Randall, Alexavier Estrada, Brian Epling, Evan H. Hart, Christie A. Lee, Younis Baqi, Christa E. Müller, Mercé Correa, John D. Salamone;
Effort-related motivational effects of the pro-inflammatory cytokine interleukin 1-beta: studiese with the concurrent fixed ratio 5/ chow feeding choice task.
Psychopharmacol. 2013, DOI 10.1007/s00213-013-3285-4

2012

Patrick A. Randall, Marta Pardo, Eric J. Nunes, Laura López Cruz, V. Kiran Vermurei, Alex Makriyannis, Younis Baqi, Christa E. Müller, Mercè Correa, John D. Salamone;
Dopaminergic modulation of effort-related choice behavior as assessed by a progressive ratio chow feeding choice task: pharmacological studies and the role of individual differences. PLOS ONE 2012, 53, 1-10.
Younis Baqi, Christa E. Müller; Efficient and mild deamination procedure for 1-aminoanthraquinones yielding a diverse library of novel derivatives with potential biological activity.
Tetrahedron letters 2012, 53, 6739-6742.
Viktor Rempel, Nicole Volz, Sonja Hinz, Tadeusz Karcz, Irene Meliciani, Martin Nieger, Wolfgang Wenzel, Stefan Bräse, Christa E. Müller;
7-Alkyl-3-benzylcoumarins: a versatile scaffold for the development of potent and selective cannabinoid receptor agonists and antagonists.
J. Med. Chem. 2012, 55, 7967-7977.
Sang-Yong Lee, Sébastien A. Lévesque, Jean Sévigny, Christa E. Müller;
A highly sensitive capillary electrophoresis method using p-nitrophenyl 5'-thymidine monophosphate as a substrate for the monitoring of nucleotide pyrophosphatase/phosphodiesterase activities.
J. Chromatogr. B 2012, 55, 162-169.
Victor Hernández-Olmos, Aliaa Abdelrahman, Ali El-Tayeb, Diana Freudendahl, Stephanie Weinhausen, Christa E. Müller;
N-Substituted phenoxazine and acridone derivatives: structure-activity relationships of potent P2X4 receptor antagonists.
J. Med. Chem. 2012, 55, 9576-9588.
Karen Knapp, Matthias Zebisch, Jan Pippel, Ali El-Tayeb, Christa E. Müller, Norbert Sträter;
Crystal structure of the human ecto-5'-nucleotidase (CD73): insights into the regulation of puringic signalling.
Stucture 2012, 20, 2161-2173.
Nikolay T. Tzvetkov, Harald Euler, Christa E. Müller;
Regioselective synthesis of 7,8-dihydroimidazo[5,1-c][1,2,4]triazine-3,6(2H,4H)-dione derivatives: A new drug-like heterocyclic scaffold.
Beilstein J. Org. Chem. 2012, 8, 1584-1593.
Ulrich Flögel, Sandra Burghoff, Peter L.E.M. van Lent, Sebastian Temme, Lisa Galbarz, Zhaoping Ding, Ali El-Tayeb, Sandra Huels, Florian Bönner, Nadine Borg, Christoph Jacoby, Christa E. Müller, Wim B. van den Berg, Jürgen Schrader; Selective activation of adenosine A2A receptors on immune cells by a CD73 dependent prodrug suppresses joint inflammation in experimental rheumatoid arthritis.
Science Transl. Med. 2012, 4, 1-8.
Nikolay Tzvetkov, Christa E. Müller;
Facile synthesis of 5-amino and 7-amino-6-azaoxindole derivatives.
Tetrahedron Lett. 2012, 53, 5597-5601.
Simone Hildenbrand, Susanne Schoch, Marec von Lehe, Rainer Surges, Christa E. Müller;
Tritium-Labeled Brivaracetam with High Specific Activity: Preparation, Characterization and Application in Human Brain Samples.
ChemMedChem 2012, 7, 1369-1374.

Carl Högberg, Olof Gidlöf, Francesca Deflorian, Kenneth A. Jacobson, Aliaa Abdelrahman, Christa E. Müller, Björn Olde, David Erlinge;
Farnesyl pyrophosphate is an endogenous antagonist to ADP-stimulated P2Y₁₂ receptor-mediated platelet aggregation.
Thromb. Haemost. 2012, 108, 119-132.
Peter Ripphausen, Marianne Freundlieb, Andreas Brunschweiger, Herbert Zimmermann, Christa E. Müller, Jürgen Bajorath;
Virtual screening identifies novel sulfonamide inhibitors of ecto-5‘-nucleotidase.
J. Med. Chem. 2012, 55, 6576-6581.
Jessica S. Santerre, Eric J. Nunes, Rotem Kovner, Chelsea E .Leser, Patrick A. Randall, Lyndsey E. Collins-Praino, Laura Lopez Cruz, Merce Correa, Younis Baqi, Christa E. Müller, John D. Salamone.
The novel adenosine A_2A antagonist prodrug MSX-4 is effective in animal models related to motivational and motor functions.
Pharmacology, Biochemistry and Behavior 2012, 102, 477-487.

Christa E. Müller, Anke C. Schiedel, Younis Baqi;
Allosteric modulators of rhodopsin-like G protein-coupled receptors: opportunities in drug development.
Pharmacol. Ther. 2012, 135, 292-315.

Marta Pardo, Laura Lopez-Cruz, Olga Valverde, Catherine Ledent, Younis Baqi, Christa E. Müller, John D. Salamone, Merce Correa;

Adenosine A_2A receptor antagonism and genetic deletion attenuate the effects of dopamine D₂ antagonism on effort-based decision making in mice.

Neuropharmacology 2012, 62, 2068-2077.

Renata Ciccarelli, Christa E. Müller, Herbert Zimmermann;
International conference on purinergic drugs and targets – 4th joint German-Italian purine club meeting, Bonn, Germany, July 22-25, 2011.
Purinergic Signal. 2012, 8, 105-106.
Sebastian Michael, Haba Abdel-Aziz, Dieter Weiser, Christa E. Müller, Olaf Kelber, Karen Nieber;
Adenosine A_2A receptor contributes to the anti-inflammatory effect of the fixed herbal combination STW5 (Iberogast®) in rat small intestinal preparations.
Naunyn-Schmiedeberg’s Arch. Pharmacol. 2012, 385, 411-421.
Sebastian Michael, H.-W. Rauwald, Haba Abdel-Aziz, Dieter Weiser, Christa E. Müller, Olaf Kelber, Karen Nieber;
Adenosine receptors: new targets to protect against tissue damage in inflammatory bowel symptoms. Sami Karoui (ed.) Inflammatory Bowel Disease – Advances in Pathogenesis and Management, 42-58, 2012.
Alessia Melani, Francesca Corti, Holger Stephan, Christa E. Müller, Paola Bruni, Maria G. Vannucchi, Felicita Pedata;
Ecto-ATPase inhibition: ATP and adenosine release under physiological and ischemic in vivo conditions in the rat striatum.
Exp. Neurol. 2012, 233, 193-204.
Younis Baqi, Christa E. Müller;
Convergent synthesis of the potent P2Y receptor antagonist MG 50-3-1 based on a regioselective Ullmann coupling reaction.
Molecules 2012, 17, 2599-2615.
Michael Gütschow, Miriam Schlenk, Jürgen Gäb, Minka Paskaleva, Muhamad Wessam Alnouri, Silvia Scolari, Jamshed Iqbal, Christa E. Müller;
Benzothiazinones: A novel class of adenosine receptor antagonists structurally unrelated to xanthine and adenine derivatives.
J. Med. Chem. 2012, 55, 3331-3341.

2011

Younis Baqi, Ralf Hausmann, Christiane Rosefort, Jürgen Retting, Günther Schmalzing, Christa E. Müller;

Discovery of potent competitive antagonists and positive modulators of the P2X2 receptor.

J. Med. Chem. 2011, 54, 817-830.
Christa E. Müller, Kenneth A. Jacobson;
Xanthines as Adenosine Receptor antagonists. B.B. Fredholm (ed.) Handbook of Experimental Pharmacology, Vol. 200, Methylxanthines, 151-199, 2011.
Christa E. Müller;
Purinrezeptoren als Zielstrukturen in der Arzneimittelforschung.
Biospektrum 2011, 17, 645-648.

Mahmoud Fahmi Elsebai, Viktor Rempel, Gregor Schnakenburg, Stefan Kehraus, Christa E. Müller, Gabriele M. König;
Identification of a potent and selective cannabinoid CB1 receptor antagonist from Auxarthron reticulatum.
Med. Chem. Lett. 2011, 2, 866-869.
Ali El-Tayeb, Sebastian Michael, Aliaa Abdelrahmen, Andrea Behrenswerth, Sabrina Gollos, Karen Nieber, Christa E. Müller;
Development of polar adenosine A_2A receptor agonists for inflammatory bowel disease: synergism with A_2B antagonists.
ACS Med. Chem. Lett. 2011, 2, 890-895.
Marie Therese Armentero, Annalisa Pinna, Sergi Ferré, José Luis Lanciego, Christa E. Müller, Rafael Franco;
Past, present and future of A_2Aadenosine receptor antagonists in the therapy of Parkinson’s disease;
Pharmacology & Therapeutics 2011, 132, 280-299.
Anna Drabczyńska, Olga Yuzlenko, Meryem Köse, Minka Paskaleva, Anke C. Schiedel, Janina Karolak-Wojciechowska, Jadwiga Handzlik, Tadeusz Karcz, Kamil Kuder, Christa E. Müller, Katarzyna Kieć-Kononowicz;
Synthesis and biological activity of tricyclic cycloalkylimidazo-, pyrimido- and diazepinopurinediones.
Eur. J. Med. Chem. 2011, 46, 3590-3607.
Zuzana Justinová, Sergi Ferré, Godfrey H. Redhi, Paola Mascia, Jessica Stroik, Davide Quarta, Sevil Yasar, Christa E. Müller, Rafael Franco, Steven R. Goldberg;
Reinforcing and neurochemical effects of cannabionid CB1 receptor agonists, but not cocaine, are altered by an adenosine A_2A receptor antagonist.
Addict. Biol. 2011, 16, 405-415.
Patrick A. Randall, Eric J. Nunes, Simone L. Janniere, Colin M. Stopper, Andrew M. Farrar, Thomas N. Sager, Younis Baqi, Jörg Hockemeyer, Christa E. Müller, John D. Salamone;
Stimulant effects of adenosine antagonists on operant behaviour: differential actions of selective A_2A and A₁ antagonists.
Psychopharmacology 2011, 216, 173-186.

Anke C. Schiedel, Sonja Hinz, Dominik Thimm, Faraq Sherbiny, Thomas Borrmann, Astrid Maaß, Christa E. Müller;
The four cysteine residues in the second extracellular loop of the human adenosine A_2B receptor: Role in ligand binding and receptor function.
Biochem. Pharmacol. 2011, 82, 389-399.
Ali El-Tayeb, Aidong Qi, Robert A. Nicholas, Christa E. Müller;
Structural modifications of UMP, UDP and UTP leading to subtype-selective agonists for P2Y₂, P2Y₄, and P2Y₆ receptors.
J. Med. Chem. 2011, 54, 2878-2890.
Mariana Pereira, Andrew M. Ferrar, Jörg Hockemeyer, Christa E. Müller, John D. Salamone, Joan I. Morrell;
Effect of the adenosine A_2A receptor antagonist MSX-3 on motivational disruptions of maternal behavior induced by dopamine antagonism in the early postpartum rat.
Psychopharmacology 2011, 213, 69-79.
Jamshed Iqbal, Christa E. Müller;
High-sensitivity capillary electrophoresis method for monitoring purine nucleoside phosphorylase and adenosine deaminase reactions by a reversed electrode polarity switching mode.
J. Chromatogr. A 2011, 1218, 4764-4771.
Lyndsey E. Collins, Nicholas E. Paul, Shams F. Abbas, Chelsea E. Leser, Samantha J. Podurgiel, Daniel J. Galtieri, James J. Chrobak, Younis Baqi, Christa E. Müller, John D. Salamone;
Oral tremor induced by galantamine in rats: A model of the parkinsonian side effects of cholinomimentics used to treat Alzheimer’s.
Pharmacol. Biochem. Behav. 2011, 99, 414-422.
Anne Pick, Henrik Müller, Ralf Mayer, Britta Haenisch, Ilza K. Pajeva, Mathias Weigt, Heinz Bönisch, Christa. E. Müller, Michael Wiese;
Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP).
Bioorg. Med. Chem. 2011, 19, 2090-2102.
Bertil B. Fredholm, Adriaan P. IJzerman, Kenneth A. Jacobson, Joel Linden, Christa E. Müller;
Nomenclature and classification of adenosine receptors – An update.
Pharmacol. Rev. 2011, 63, 1-34.
Miriam C. Peeters, Gerard J. P. van Westen, Dong Guo, Lisanne E. Wisse, Christa E. Müller, Margot W. Beukers, Adriaan P. IJzerman;
GPCR structure and activation: an essential role for the first extracellular loop in activating the adenosine A_2B receptor.
FASEB J. 2011, 25,632-643.

Christa E. Müller, Kenneth A. Jacobson;
Recent developments in adenosine receptor ligands and their potential as novel drugs.
Biochim. Biophys. Acta – Biomembranes 2011, 1290-1308.
Anna Drabczyńska, Małgorzata Zygmunt, Jacek Sapa, Barbara Filipek, Christa E. Müller, Katarzyna Kieć-Kononowicz;
Antiparkinsonian effects of novel adenosine A_2A receptor antagonists.
Arch. Pharm. Chem. Life Sci. 2011, 344,20-27.

2010 - 2006

2010

Sandra Dettmann, Katrin Szymanowitz, Anja Wellner, Anke Schiedel, Christa E. Müller;
2-Phenyl-1-[4-(2-piperidine-1-yl-ethoxy)benzyl]-1H-benzimidazoles as ligands for the estrogen receptor: Synthesis and pharmacological evaluation.
Bioorg. Med. Chem. 2010, 18, 4905-4916.
Harald Euler, Armin Kirfel, Amelie Zech, Jörg Hockemeyer, Christa E. Müller;
Crystal structure of 6-amino-3-cyclopropyl-1-ethyl-1H-pyrimidine-2,4-dione hydrate, C₉H₁₃N₃O₂H₂O.
Z. Kristallogr. NCS 2010, 225, 595-596.

Lyndsey E. Collins, Daniel J. Galtieri, Patricia Collins, Shawnet K. Jones, Russel G. Port, Nicholas E. Paul, Jörg Hockemeyer, Christa E. Müller, John D. Salamone;
Interactions between adenosine and dopamine receptor antagonists with different selectivity profiles: Effects on locomotor activity.
Behav. Brain Res. 2010, 211, 148-155.
Younis Baqi, Christa E. Müller;
Synthesis of alkyl- and aryl-amino-substituted anthraquinone derivatives by microwave-assisted copper(0)-catalyzed Ullmann coupling reactions.
Nat. Protocols 2010, 5, 945-953.
Lyndsey E. Collins, Daniel J. Galtieri, Lise T. Brennum, Thomas N. Sager, Jörg Hockemeyer, Christa E. Müller, James R. Hinman, James J. Chrobak, John D. Salamone;
Oral tremor induced by the muscarinic agonist pilocarpine is suppressed by the adenosine A_2A antagonists MSX-3 and SCH58261, but not the adenosine A₁ antagonist DPCPX.
Pharmacology, Biochemistry and Behavior 2010, 94, 561-569.
Sebastian Michael, Claudia Warstat, Fabien Michel, Luo Yan, Christa E. Müller, Karen Nieber;
Adenosine A_2A agonist and A_2B antagonist mediate an inhibition of inflammation-induced contractile disturbance of a rat gastrointestinal preparation.
Purinergic Signal. 2010, 6, 117-124.
Anja B. Scheiff, Swapnil G. Yerande, Ali El-Tayeb, Wenjin Li, Gajanan S. Inamdar, Kamala K. Vasu, Vasudevan Sudarsanam, Christa E. Müller;
2-Amino-5-benzoyl-4-phenylthiazoles: development of potent and selective adenosine A₁ receptor antagonists.
Bioorg. Med. Chem. 2010, 18, 2195-2203.
Andrew M. Farrar, Kristen N. Segovia, Patrick A. Randall, Lyndsey E. Collins, Eric J. Nunes, Colin Stopper, Jörg Hockemeyer, Christa E. Müller, Merce Correa, John D. Salamone;
Nucleus accumbens and effort-related functions: behavioural and neural markers of the interactions between adenosine A_2A and dopamine D₂ receptors.
Neuroscience 2010, 166, 1056-1067.
Thomas Emmrich, Ali El-Tayeb, Hesham Taha, Roland Seifert, Christa E.Müller, Andreas Link;
Synthesis of a hydrolytically stable, fluorescent-labeled ATP analog as a tool for probing adenylyl cyclases.
Bioorg. Med. Chem. Lett. 2010, 20, 232-235.
Giana P. Cognato, Paula M. Agostinho, Jörg Hockemeyer, Christa E. Müller, Diogo O. Souza, Rodrigo A. Cunha;
Caffeine and an adenosine A_2A receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life.
J. Neurochem. 2010, 112, 453-462.
Jamshed Iqbal, Aileen Knowles, Christa E. Müller;
Development of a microbioreactor with ecto-nucleoside triphosphate diphosphohydrolase 2 (NTPDase2) immobilized on a polyacrylamide-coated capillary at the outlet.
J. Chromatogr. A, 2010, 1217, 600-604.
Younis Baqi, Sang-Yong Lee, Jamshed Iqbal, Peter Ripphausen, Anne Lehr, Anja B. Scheiff, Herbert Zimmermann, Jürgen Bajorath, Christa E. Müller;
Development of potent and selective inhibitors of ecto-5’-nucleotidase based on an anthraquinone scaffold.
J. Med. Chem. 2010, 53, 2076-2086.

Xiaofeng Sun, Yan Wu, Wenda Gao, Keiichi Enjyoji, Eva Csizmadia, Christa E. Müller, Takashi Murakami, Simon C. Robson;
CD39/ENTPD1 expression by CD4+Foxp3+ regulatory T cells promotes hepatic metastatic tumor growth in mice.
Gastroenterology 2010, 139, 1030-1040.
Christa E. Müller, Sergi Ferré;
Blocking striatal adenosine A_2A receptors: a new strategy for basal ganglia disorders;
Frontiers in CNS Drug Discovery 2010, 1, 304-341.
Christa E. Müller;
Emerging structures and ligands for P2X3 and P2X4 receptors - towards novel treatments of neuropathic pain.
Purinergic Signal. 2010, 6, 145-148.

2009

Harald Euler, Bruno Barbier, Nikolay T. Tzvetkov, Christa E. Müller;
Crystal structure of 3-benzyl-5,5-dimethylimidazolidine-2,4-dione, C₁₂H₁₄N₂O₂.
Z. Kristallogr. NCS 2009, 224, 601-602 .
Ali El-Tayeb, Jamshed Iqbal, Andrea Behrenswerth, Michael Romio, Marion Schneider, Herbert Zimmermann, Jürgen Schrader, Christa E. Müller;
Nucleoside-5’monophosphates as prodrugs of adenosine A_2A receptor agonists activated by ecto-5’-nucleotidase.
J. Med. Chem. 2009, 52, 7669-7677.
Christa E. Müller;
Prodrug approaches for enhancing the bioavailability of drugs with low solubility.
Chemistry & Biodiversity 2009, 6, 2071-2083.
Faraq F. Sherbiny, Anke C. Schiedel, Astrid Maaß, Christa. E. Müller;
Homology modelling of the human adenosine A_2B receptor based on X-ray structures of bovine rhodopsin, the β₂-adrenergic receptor and the human adenosine A_2A receptor.
J. Comput. Aided Mol. Des. 2009, 23, 807-828.
Thomas Borrmann, Aliaa Abdelrahman, Rosaria Volpini, Catia Lambertucci, Edgars Alksnis, Simone Gorzalka, Melanie Knospe, Anke C. Schiedel, Gloria Cristalli, Christa E. Müller;
Structure-activity relationships of adenine and deazaadenine derivatives as ligands for adenine receptors, a new purinergic receptor family.
J. Med. Chem. 2009, 52, 5974-5989.
Carina Klein, Anja Grahnert, Aliaa Abdelrahman, Christa E. Müller, Sunna Hauschildt;
Extracellular NAD⁺ induces a reise in [Ca²⁺] in activated human monocytes via engagement of P2Y₁ and P2Y₁₁ receptors.
Cell Calcium 2009, 46, 263-272.
Kristina Hoffmann, Younis Baqi, María S. Morena, Markus Glänzel, Christa E. Müller, Ivar von Kügelgen;
Interaction of new, very potent non-nucleotide antagonists with Arg256 of the human platelet P2Y₁₂ receptor.
J. Pharmacol. Exp. Ther. 2009, 331, 648-655.
Carsten Linnemann, Frank A. Schildberg, Anna Schurich, Linda Diehl, Silke I. Hegenbarth, Elmar Endl, Svenja Lacher, Christa E. Müller, Jürgen Frey, Luca Simeoni, Burkhart Schraven, Dirk Stabenow, Percy A. Knolle;
Adenosine regulates CD8 T-cell priming by inhibition of membrane-proximal T-cell receptor signalling.
Immunology 2009, 128, 728-737.
Roland Sauer, Ali El-Tayeb, Marko Kaulich, Christa E. Müller;
Synthesis of uracil nucleotide analogs with a modified, acyclic ribose moiety as P2Y₂ receptor antagonists.
Bioorg. Med. Chem. 2009, 17, 5071-5079.
Thomas Borrmann, Sonja Hinz, Daniela C. G. Bertarelli, Wenjin Li, Nicole C. Florin, Anja B. Scheiff, Christa E. Müller;
1-Alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A_2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specifity.
J. Med. Chem. 2009, 52, 3994-4006
Younis Baqi, Kerstin Atzler, Meryem Köse, Markus Glänzel, Christa E. Müller;
High-affinity, non-nucleotide-derived competitive antagonists of platelet P2Y₁₂ receptors.
J. Med. Chem. 2009, 52, 3784-3793.
Petra Hillmann, Geun-Yung Ko, Andreas Spinrath, Alexandra Raulf, Ivar von Kügelgen, Samuel C. Wolff, Robert A. Nicholas, Evi Kostenis, Hans-Dieter Höltje and Christa E. Müller
Key determinants of nucleotide-activated G protein-coupled P2Y₂ receptor function revealed by chemical and pharmacological experiments, mutagenesis and homology modeling.
J. Med. Chem., 2009, 52, pp 2762–2775.
Harald Euler, Armin Kirfel, Ali El-Tayeb, Christa E. Müller;
Crystal structure of 1-(2R, 3R, 4S, 5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydrofuran-2-yl-2-propylsulfanyl-1H-pyrimidin-4-one, C₁₂H₁₈N₂O₅S.
Z. Kristallogr. NCS 2009, 224, 107-108.
Younis Baqi, Stefanie Weyler, Jamshed Iqbal, Herbert Zimmermann, Christa E. Müller;
Structure-activity relationships of anthraquinone derivatives derived from bromaminic acid as inhibitors of ecto-nucleoside triphosphate diphosphohydrolases (E-NTPDases).
Purinergic Signal. 2009, 5, 91-106.
Andrea Behrenswerth, Nicole Volz, Jakob Toräng, Sonja Hinz, Stefan Bräse, Christa E. Müller;
Synthesis and pharmacological evaluation of coumarin derivatives of cannabinoid receptor antagonists and inverse agonists.
Bioorg. Med. Chem. 2009, 2842-2851.
Christa E. Müller, Carolin Roegler, Jörg Hockemeyer;
5,5’-Bipyridyl-2,4,6,2’,4’,6’-hexaone derivatives (hydurilic acids): syntheses, mechanism of C-C-bond formation and properties of the dimeric barbituric acid derivatives.
Heterocycles 2009, 79, 703-720.
Lila Worden, Mona Shahriari, Andrew Farrar, Kelly S. Sink, Jörg Hockemeyer, Christa. E. Müller, John D. Salamone;
The adenosine A_2Aantagonist MSX-3 reverses the effort-related effects of dopamine blockade: differential interaction with D₁ and D₂ family antagonists.
Psychopharmacology 2009, 203, 489-499.
Allison M. Mott, Eric J. Nunes, Lyndsey E. Collins, Russell G. Port, Kelly S. Sink, Jörg Hockemeyer, Christa E. Müller, John D. Salamone;
The adenosine A_2A antagonist MSX-3 reverses the effects of the dopamine antagonist haloperidol on effort-related decision making in a T-maze cost/benefit procedure.
Psychopharmacology 2009, 204, 103-112.
Gloria Cristalli, Christa E. Müller, Rosaria Volpini;
Recent developments in adenosine A_2A receptor ligands in: Wilson, Constance N.; Mustafa, S. Jamal (Hrsg.)
Handbook of Experimental Pharmacology, Vol. 193, Adenosine Receptors in Health and Disease, 2009.
Elsbieta Pękala, Joachim C. Burbiel, Christa E. Müller;
Preparation of enantiopure (R)-hydroxy metabolite of denbufylline using immobilized Lactobacillus kefiri DSM 20587 as a catalyst.
Chirality 2009, 21, 713-718.

2008

Fiona M. Sansom, Patrice Riedmaier, Hayley J. Newton, Michelle A. Dunstone, Christa E. Müller, Holger Stephan, Emma Byres, Travis Beddoe, Jame Rossjohn, Peter J. Cowan, Anthony J. F. d’Apice, Simon C. Robson, Elizabeth L. Hartland;
Enzymatic properties of an ecto-nucleotidase triphosphate diphosphohydrolase from Legionella pneumophila: substrate specificity and requirement for virulence.
J. Biol. Chem. 2008, 283, 12909-12918.
John D. Salamone, Adrienne J. Betz, Keita Ishiwari, Jennifer Felsted, Lisa Madson, Brian Mirante, Karen Clark, Laura Font, Samantha Korbey, Thomas N. Sager, Jörg Hockemeyer, Christa E. Müller;
Tremorolytic effects of adenosine A_2A antagonists: implications for parkinsonism.
Front. Biosci. 2008, 13, 3594-3605.

Jamshed Iqbal, David Jirovsky, Sang-Yang Lee, Herbert Zimmermann, Christa E. Müller;
Capillary electrophoresis-based nanoscale assays for monitoring ecto-5’-nucleotidase activity and inhibition in preparations of recombinant enzyme and melanoma cell membranes.
Anal. Biochem. 2008, 373, 129-140.
Stefanie Weyler, Younis Baqi, Petra Hillmann, Marko Kaulich, Andrea M. Hunder, Ingrid A. Müller, Christa E. Müller;
Combinatorial synthesis of anilinoanthraquinone derivates and evaluation as non-nucleotide-derived P2Y₂ receptor antagonists.
Bioorg. Med. Chem. Lett. 2008, 18, 223-227.
Ivar von Kügelgen, Anke C. Schiedel, K. Hoffmann, Bernt B. Alsdorf, Aliaa Abdelrahman, Christa E. Müller;
Cloning and functional expression of a novel G_i protein-coupled receptor for adenine from mouse brain.
Mol. Pharmacol. 2008, 73, 469-477.
Petra Hillmann, Meryem Köse, Kristina Söhl, Christa E. Müller;
Ammonium-induced calcium mobilization in 1321N1 astrocytoma cells.
Toxicol. Appl. Pharmacol. 2008, 227, 36-47.
Karl Vollmann, Ramatullah Qurishi, Jörg Hockemeyer, Christa E. Müller;
Synthesis and properties of a new water-soluble prodrug of the adenosine A_2A receptor antagonist MSX-2.
Molecules 2008, 13, 348-359.
Andras Bilkei-Gorzo, Osama M. Abo-Salem, Alaa M. Hayallah, Kerstin Michel, Christa E. Müller, Andreas Zimmer;
Adenosine receptor subtype-selective antagonists in inflammation and hyperalgesia.
Naunyn-Schmiedebergs Arch. Pharmacol. 2008, 377, 65-76.
Geanne M. Cunha, Paula M. Canas, Carolina S. Melo, Jörg Hockemeyer, Christa E._Müller, Catarina R. Oliveira, Rodrigo A. Cunha;
Adenosine A_2A receptor blockade prevents memory dysfunction caused by beta-amyloid peptides but not by scopolamine or MK-801.
Exp. Neurol. 2008, 210, 776-781.
Liqun Yu, Hai-Ying Shen, Joana E. Coelho, Inês M. Araújo, Qing-Yuan Huang, Yuan-Ji Day, Nelson Rebola, Paula M. Canas, Erica Kirsten Rapp, Jarrod Ferrara, Darcie Taylor, Christa E. Müller, Joel Linden, Rodrigo A. Cunha, Jiang-Fan Chen;
A_2A Receptors modulate motor activity and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity by distinct cellular mechanisms.
Ann. Neurol. 2008, 63, 338-346.
Daniel Marcellino, Paulina Carriba, Małgorzata Filip, Anders Borgkvist, Małgorzata Frankowska, Immaculada Bellido, Sergio Tanganelli, Christa E. Müller, Gilberto Fisone, Carme Lluis, Luigi F. Agnati, Rafael Franco, Kjell Fuxe;
Antagonistic cannabinoid CB₁/dopamine D₂ receptor interactions in striatal CB₁/D₂heteromers. A combined neurochemical and behavioural analysis.
Neuropharmacology 2008, 54, 815-823.
Marcel Töpfer, Joachim C. Burbiel, Christa E. Müller, J. Knittel, Eugen J. Verspohl;
Modulation of insulin release by adenosine A₁ receptor agonists and antagonists in INS-1 cells: the possible contribution of ⁸⁶Rb₊ efflux and ⁴⁵Ca²⁺ uptake.
Cell Biochem. Funct. 2008, 26, 833-843.
Andreas Brunschweiger, Jamshed Iqbal, Frank Umbach, Anja B. Scheiff, Mercedes N. Munkonda, Jean Sévigny, Aileen F. Knowles, Christa E. Müller;
Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase 2) inhibitors: nucleotide mimetics derived from uridine-5’-carboxamide.
J. Med. Chem. 2008, 51, 4518 - 4528.
Jamshed Iqbal, Sébastien A. Lévesque, Jean Sévigny, Christa E. Müller;
A highly sensitive CE-UV method with dynamic coating of silica-fused capillaries for the monitoring of nucleotide pyrophosphatase/phosphodiesterase reactions.
Electrophoresis 2008, 29, 3685-3693.
Christa E. Müller;
Parkinson-Therapeutika: Was gibt es Neues?
Apotheken-Magazin – Fachmagazin für Pharm. Fortbildung 2008, 25, 8-12.
John D. Salamone, Keita Ishiwari, Adrienne J. Betz, Andrew M. Farrar, Susanna M. Mingote, Laura Font, Jörg Hockemeyer, Christa. E. Müller, Merce Correa;
Dopamine/adenosine interactions related to locomotion and tremor in animal models: possible relevance to parkinsonism.
Parkinsonism Relat. Disord. 2008, 14 Suppl. 2, S130-134.

2007

Svenja K. Lacher, Ralf Mayer, Kathrin Sichardt, Karen Nieber, Christa E. Müller;
Interaction of valerian extracts of different polarity with adenosine receptors: Identification of isovaltrate as an inverse agonist at A₁ receptors.
Biochem. Pharmacol. 2007, 73, 248-258.
Jamshed Iqbal, Leonardo Scapozza, Gerd Folkers, Christa E. Müller;
Development and validation of a capillary electrophoresis method for the characterization of herpes simplex virus type 1 (HSV-1) thymidine kinase substrates and inhibitors.
J. Chromatogr. B 2007, 846, 281-290.
Tadeusz Librowski, Monika Kubacka, Manuela Meusel, Silvia Scolari, Christa E. Müller, Michael Gütschow;
Evaluation of anticonvulsant and analgesic effects of benzyl- and benzhydryl ureides.
Eur. J. Pharmacol. 2007, 559, 138-149.
Christa E Müller and Sergi Ferré;
Blocking striatal adenosine A_2Areceptors : a new strategy for basal ganglia disorders
Recent Patents on CNS Drug Discovery, 2007, 2, 1-21.
Younis Baqi, Christa E. Müller;
Rapid and efficient microwave-assisted copper(0)-catalyzed Ullmann coupling reaction: general access to anilinoanthraquinone derivatives.
Org. Lett. 2007, 9, 1271-1274.
Almut Grenz, Hua Zhang, Marina Hermes, Tobias Eckle, Karin Klingel, Dan Yang Huang, Christa. E. Müller, Simon C. Robson, Hartmut Osswald, Holger Eltzschig;
Contribution of E-NTPDase1 (CD39) to renal protection from ischemia-reperfusion injury.
FASEB J. 2007, 21, 2863-2873.
Stéphane Massip, Jean Guillon, Pascal Sonnet, Jean-Michel Léger, Jean-Jacques Bosc, Christa E. Müller, Christian Jarry;
The reactivity of related 6-amino- and 5,6-diaminouracils derived from 2-amino-5-(phenoxymethyl)-2-oxazoline: efficient access to bicyclic pyrimidine derivatives.
Synthesis 2007, 14, 2193-2197.
Dirk Bokemeyer, Darius Panek, Masashi Kitahara, James M. Trzaskos, Christa E. Müller, Jörg Hockemeyer, Uta Kunter, Peter Boor, Jürgen Floege, Herbert J. Kramer, Tammo Ostendorf;
The map kinase ERK regulates renal activity of cyclin dependent kinase 2 in experimental glomerulonephritis.
Nephrol. Dial. Transplant 2007, 22, 3431-3441.
Andrew M. Farrar, Mariana Pereira, Francisco Velasco, Jörg Hockemeyer, Christa E. Müller;
Adenosine A_2A receptor antagonism reverses the effects of dopamine receptor antagonism on instrumental output and effort-related choice in the rat: implications for studies of psychomotor slowing.
Psychopharmacology 2007, 191, 579-586.
Younis Baqi, Christa E. Müller;
Catalyst-free microwave-assisted amination of 2-chloro-5-nitrobenzoic acid.
J. Org. Chem. 2007, 72, 5908-5911.
Anna Drabczyńska, Christa E. Müller, Janina Karolak-Wojciechowska, Britta Schumacher, Anke Schiedel, Olga Yuzlenko, Katarzyna Kieć-Kononowicz;
N9-Benzyl-substituted 1,3-dimethyl- and 1,3-dipropyl-pyrimido[2,1-f]purinediones: synthesis and structure-activity relationships at adenosine A₁ and A_2A receptors.
Bioorg. Med. Chem. 2007, 15, 5003-5017.
Anna Drabczyńska, Christa E. Müller, Anke Schiedel, Britta Schumacher, Janina Karolak-Wojciechowska, Andrzej Fruziński, Weronika Zobnina, Olga Yuzlenko, Katarzyna Kieć-Kononowicz;
Phenylethyl-substituted pyrimido[2,1-f]purinediones and related compounds: Structure–activity relationships as adenosine A₁ and A_2A receptor ligands.
Bioorg. Med. Chem. 2007, 15, 6956-6974.
Paulina Carriba, Oskar Ortiz, Kshitij Patkar, Zuzana Justinova, Jessica Stroik, Andrea Themann, Christa E. Müller, Anima S. Woods, Bruce T. Hope, Francisco Ciruela, Vicent Casadó, Enric I. Canela, Carmen Lluis, Steven R. Goldberg, Rosario Moratalla, Rafael Franco, Sergi Ferré;
Striatal adenosine A_2A and cannabinoid CB₁ receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids.
Neuropsychopharmacology 2007, 32, 2249-2259.
Keita Ishiwari, Lisa J. Madson, Andrew M. Farrar, Susana M. Mingote, John P. Valenta, Michael D. DiGianvittorio, Lauren E. Frank, Merce Correa, Jörg Hockemeyer, Christa E. Müller, John D. Salamone;
Injections of the selective adenosine A_2A antagonist MSX-3 into the nucleus accumbens core attenuate the locomotor suppression induced by haloperidol in rats.
Behavioural Brain Res 2007, 178, 190-199.
Elisabetta Coppi, Anna Maria Pugliese, Holger Stephan, Christa E. Müller, Felicita Pedata;
Role of P2 purinergic receptors on synaptic transmission under normoxic and ischaemic conditions in the CA1 of rat hippocampal slices.
Purinergic Signal. 2007, 3, 203-219.
Anke C. Schiedel, Heiko Meyer, Bernt B. A. Alsdorf, Simone Gorzalka, Hannelore Brüssel, Christa E. Müller;
[³H]Adenine is a suitable radioligand for the labeling of G protein-coupled adenine receptors but shows high affinity to bacterial contaminations in buffer solutions.
Purinergic Signal. 2007, 3, 347-358.
David Köhler, Tobias Eckle, Marion Faiglem, Almut Grenz, Michel Mittelbronn, Stefanie Laucher, Melanie L. Hart, Simon C. Robinson, Christa E. Müller, Holger K. Eltzschig;
CD39/Ectonucleoside triphosphate diphosphohydrolase 1 provides myocardial protection during cardia ischemia/reperfusion injury.
Circulation 2007, 116, 1784-1794.

2006

Joachim C. Burbiel, Jörg Hockemeyer, Christa E. Müller;
Synthesis of xanthine derivatives by microwave-assisted ring closure reaction.
ARKIVOC 2006, 77-82.
Andreas Brunschweiger, Christa E. Müller;
P2 Receptors activated by uracil nucleotides – an update.
Curr. Med. Chem. 2006, 13, 289-312.
Stéphane Massip, Jean Guillon, Daniela Bertarelli, Jean-Jacques Bosc, Jean-Michel Léger, Svenja Lacher, Cécile Bontemps, Thibaut Dupont, Christa E. Müller, Christian Jarry;
Synthesis and preliminary evaluation of new 1- and 3-[1-(2-hydroxy-3-phenoxypropyl)xanthines from 2-amino-2-oxazolines as potential A₁ and A_2A adenosine receptor antagonists.
Bioorg. Med. Chem. 2006, 14, 2697-2719.
Jacek Bulicz, Daniela C. G. Bertarelli, Dieter Baumert, Friederike Fülle, Christa. E. Müller, Dieter Heber;
Synthesis and pharmacology of pyrido[2,3-d]pyrimidinediones bearing polar substituents as adenosine receptor antagonists.
Bioorg. Med. Chem. 2006, 14, 2837-2849.
Jamshed Iqbal, Joachim C. Burbiel, Christa E. Müller;
Development of off-line and on-line capillary electrophoresis method for the screening and characterization of adenosine kinase inhibitors and substrates.
Electrophoresis 2006, 27, 2505-2517.
Andreas Brunschweiger, Christa E. Müller;
Medizinische Chemie der Diuretika.
Pharm. Unserer Zeit 2006, 4, 310-320.
Luo Yan, Daniela C. G. Bertarelli, Alaa M. Hayallah, Heiko Meyer, Karl-Norbert Klotz, Christa E. Müller;
A new synthesis of sulfonamides by aminolysis of p-nitrophenylsulfonates yielding potent and selective adenosine A_2B receptor antagonists.
J. Med. Chem. 2006, 49, 4384-4391.
Daniela C. G. Bertarelli, Martina Diekmann, Alaa M. Hayallah, Dorothee Rüsing, Jamshed Iqbal, Birgit Preiss, Eugen J. Verspohl, Christa E. Müller;
Characerization of human and rodent native and recombinant adenosine A_2B receptors by radioligand binding studies.
Purinergic Signal. 2006, 2, 559-571.
Stefanie Weyler, Friederike Fülle, Martina Diekmann, Britta Schumacher, Sonja Hinz, Karl-Norbert Klotz, Christa E. Müller;
Improving potency, selectivity, and water solubility of adenosine A₁ receptor antagonists: xanthines modified at position 3 and related pyrimido[1,2,3-cd]purinediones.
ChemMedChem. 2006, 1, 891-902.
Rhalid Akkari, Joachim Burbiel, Jörg Hockemeyer, Christa E. Müller;
Recent progress in the development of adenosine receptor ligands as antiinflammatory drugs.
Curr. Top. Med. Chem. 2006, 6, 1375-1399.
Christa E. Müller, Jamshed Iqbal, Younis Baqi, Herbert Zimmermann, Anita Röllich, Holger Stephan;
Polyoxometalates – a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors.
Bioorg. Med. Chem. Lett. 2006, 16, 5943-5947.
Małgorzata Filip, Małgorzata Frankowska, Magdalena Zaniewska, Edmund Przegaliński, Christa E. Müller, Luigi F. Agnati, Rafael Franco, David C. S. Roberts, Kjell Fuxe;
Involvement of adenosine A_2A and dopamine receptors in the locomotor and sensitizing effects of cocaine.
Brain Res. 2006, 1077, 67-80.
Ali El-Tayeb, Aidong Qi, Christa E. Müller;
Synthesis and Structure-Activity Relationships of Uracil Nucleotide Derivatives and Analogues as Agonists of Human P2Y₂, P2Y₄, and P2Y₆ Receptors.
J. Med. Chem. 2006, 49, 7076-7087.
Christa. E. Müller, Jamshed Iqbal, Younis Baqi;
Kapillarelektrophorese-Nano-Assays in der Wirkstofftestung – Neue In-vitro-Screening-Verfahren auf der Suche nach Arzneistoffen in der Zukunft.
GIT Labor-Fachzeitschrift 2006, 10, 897-900.
Christa E. Müller, Jamshed Iqbal, Younis Baqi;
Capillary electrophoresis nano-assays - novel in vitro screening methods for future drugs.
Screening 2006, 4, 26-28.
Dorothee Rüsing, Christa E. Müller, Eugen J. Verspohl;
The impact of adenosine and A_2B receptors on glucose homoeostasis.
J. Pharm. Pharmacol. 2006, 58, 1639-1645.
Joachim C. Burbiel, Jörg Hockemeyer, Christa E. Müller;
Microwave-assisted ring closure reactions: Synthesis of 8-substituted xanthine derivatives and related pyrimido- and diazepinopurinediones.
Beilstein J. Org. Chem. 2006, 2, No. 20.
Anna Drabczyńska, Christa E. Müller, Svenja K. Lacher, Britta Schumacher, Janina Karolak-Wojciechowska, Antony Nasal, Piotr Kawczak, Olga Yuzlenko, Elżbieta Pękala, Katarzyna Kieć-Kononowicz;
Synthesis and biological activity of tricyclic aryloimidazo-, pyrimido-, and diazepinopurinediones.
Bioorg. Med. Chem. 2006, 14, 7258-7281.
H. Phuoc Le, Christa E. Müller;
Rapid microwave-assisted fluorourination yielding novel 5’-deoxy-5’-fluoridine derivatives.
Bioorg. Med. Chem. Lett. 2006, 16, 6139-6142.

2005 - 2001

Kerstin Grießmeier, Christa E. Müller;
[³H]BQ-123 binding to native endothelin ETa receptors in human astrocytoma 1321N1 cells and screening of potential ligands.
Pharmacology 2005, 74, 51-56.
Simone Gorzalka, Sauro Vittori, Rosaria Volpini, Gloria Cristalli, Ivar von Kügelgen, Christa E. Müller;
Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues.
Mol. Pharmacol. 2005, 67, 955-964.
Janez Ilas, Slavko Pekar, Jörg Hockemeyer, Harald Euler, Armin Kirfel, Christa E. Müller;
Development of spin-labeled probes for adenosine receptors.
J. Med. Chem. 2005, 48, 2108-2114.
Marcello Solinas, Sergi Ferré, Katerina Antoniou, Davide Quarta, Zuzana Justinova, Jörg Hockemeyer, L. A. Pappas, P. N. Segal, C. Wertheim, Christa E. Müller, Steven R. Goldberg;
Involvement of adenosine A₁ receptors in the discriminative-stimulus effects of caffeine in rats.
Psychopharmacology 2005, 179, 576-586.
Bernd Kammerer, Antje Frickenschmidt, Christa E. Müller, Stefan Laufer, Christoph H. Gleiter, Hartmut Liebich;
Mass spectrometric identification of modified urinary nucleosides used as potential biomedical markers by LC-ITMS coupling.
Anal. Bioanal. Chem. 2005, 382, 1017-1026.
Ali El-Tayeb, Kerstin J. Griessmeier, Christa E. Müller;
Synthesis and preliminary evaluation of [³H]PSB-0413, a selective antagonist radioligand for platelet P2Y₁₂ receptors.
Bioorg. & Med. Chem. Lett. 2005, 15, 5450-5452.
Jamshed Iqbal, Petra Vollmayer, Norbert Braun, Herbert Zimmermann, Christa E. Müller;
A capillary electrophoresis method for the characterization of ecto-nucleoside triphosphate diphosphohydrolases (NTPDases) and the analysis of inhibitors by in-capillary enzymatic microreaction.
Purinergic Signal. 2005, 1, 349-358.
Charles W. Schindler, Marzena Karcz-Kubicha, Eric B. Thorndike, Christa E. Müller, Srihari R. Tella, Sergi Ferré, Steven R. Goldberg;
Role of central and peripheral adenosine receptors in the cardiovascular responses to intraperitoneal injections of adenosine A₁ and A_2A subtype receptor agonists.
Br. J. Pharmacol. 2005, 144, 642-650.
Katerina Antoniou, Z. Papadopoulou-Daifoti, T. Hyphantis, G. Papathanasiou, E. Bekris, M. Marselos, L. Panlilio, Christa E. Müller, Steven R. Goldberg, Sergi Ferré;
A detailed behavioral analysis of the acute motor effects of caffeine in the rat: involvement of adenosine A₁ and A_2A receptors.
Psychopharmacology 2005, 183, 154-162.

2004

Osama M. Abo-Salem, Alaa M. Hayallah, Andras Bilkei-Gorzo, Barbara Filipek, Andreas Zimmer, Christa E. Müller;
Antinociceptive effects of novel A_2B adenosine receptor antagonists.
J. Pharmacol. Exp. Ther. 2004, 308, 358-366.
Luo Yan, Christa E. Müller;
Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic acid prodrugs with peroral bioavailability.
J. Med. Chem. 2004, 47, 1031-1043.
Katarzyna Kieć-Kononowicz, Janina Karolak-Wojciechowska, Barbara Michalak, Elzbieta Pękala, Britta Schumacher, Christa E. Müller;
Imidazo[2,1-b]thiazepines: synthesis, structure and evaluation of benzodiazepine receptor binding.
Eur. J. Med. Chem. 2004, 39, 205-218.
Charles W. Schindler, Marzena Karcz-Kubicha, Eric B. Thorndike, Christa E. Müller, Srihari R. Tella, Steven R. Goldberg, Sergi Ferré;
Lack of adenosine A₁ and dopamine D₂ receptor-mediated modulation of the cardiovascular effects of the adenosine A_2A receptor agonist CGS 21680.
Eur. J. Pharmacol. 2004, 484, 269-275.
Stefan Kehraus, Simone Gorzalka, Christian Hallmen, Jamshed Iqbal, Christa E. Müller, Anthony D. Wright, Michael Wiese, Gabriele M. König;
Novel amino acid derived natural products from the Ascidian Atriolum robustum: Identification and pharmacological characterization of a unique adenosine derivative.
J. Med. Chem. 2004, 47, 2243 - 2245.
Jörg Hockemeyer, Joachim C. Burbiel, Christa E. Müller;
Multigram-scale syntheses, stability, and photoreactions of A_2A adenosine receptor antagonists with 8-styrylxanthine structure - potential drugs for Parkinson's disease.
J. Org. Chem. 2004, 69, 3308-3318.
Anna Drabczyńska, Christa E. Müller, Britta Schumacher, Sonja Hinz, Janina Karolak-Wojciechowska, Barbara Michalak, Elzbieta Pękala, Katarzyna Kieć-Kononowicz;
Tricyclic oxazolo[2,3-f]purinediones: Potency as adenosine receptor ligands and anticonvulsants.
Bioorg. Med. Chem. 2004, 12, 4895-4908.
Christa E. Müller;
Diuretika – Neue Errungenschaften.
Pharm. Ztg. 2004, 149, 16-22.

2003

Stefanie Weyler, Alaa M. Hayallah, Christa E. Müller;
Versatile, convenient synthesis of pyrimido[1,2,3-cd]purinediones.
Tetrahedron 2003, 59, 47-54.
Zhan-Guo Gao, Neli Melman, Andreas Erdmann, Seong Gon Kim, Christa E. Müller, Adriaan P. IJzerman, Kenneth A. Jacobson;
Differential allosteric modulation by amiloride analogues of agonist and antagonist binding at A₁ and A₃ Adenosine Receptors.
Biochem. Pharmacol. 2003, 65, 525-534.
Christa E. Müller;
Medicinal chemistry of adenosine A₃ receptor ligands.
Curr. Top. Med. Chem. 2003, 3, 445-462.
Vita Ozola, Mark Thorand, Martina Diekmann, Ramatullah Qurishi, Britta Schumacher, Kenneth A. Jacobson, Christa E. Müller;
2-Phenylimidazo[2,1-i]purin-5-ones: structure-activity relationships and characterization of potent and selective inverse agonists at human A₃ adenosine receptors.
Bioorg. Med. Chem. 2003, 11, 347-356.
Omeran Fihd, Maciej Pawłowski, Sławomir Jurczyk, Christa E. Müller, Britta Schumacher;
Pyrimidin-8-on[2,1-f]theophylline-9-alkylcarboxylic acids amides as A₁and A_2A adenosine receptor ligands.
Il Farmaco 2003, 58, 439-444.
Marko Kaulich, Ramatullah Qurishi, Christa E. Müller;
Extracellular metabolism of nucleotides in neuroblastoma x glioma NG108-15 cells determined by capillary electrophoresis.
Cell. Mol. Neurobiol. 2003, 23, 349-364.
Marko Kaulich, Franziska Streicher, Ralf Mayer, Ingrid Müller, Christa E. Müller;
Flavonoids – novel lead compounds for the development of P2Y₂ receptor antagonists.
Drug Dev. Res. 2003, 59, 72-81.
Anna Drabczyńska, Britta Schumacher, Christa E. Müller, Janina Karolak-Wojciechowska, Barbara Michalak, Elżbieta Pękala, Katarzyna Kieć-Kononowicz;
Impact of the aryl substituent kind and distance from pyrimido[2,1-f]purindiones on the adenosine receptor selectivity and antagonistic properties.
Eur. J. Med. Chem. 2003, 38, 397-402.
David Blum, Marie-Christine Galas, Annita Pintor, Emmanuel Brouillet, Catherine Ledent, Christa E. Müller, Kadiombo Bantubungi, Mariangela Galluzzo, David Gall, Laetitia Cuvelier, Anne-Sophie Rolland, Patrizia Popoli, Serge N. Schiffmann;
A dual role of adenosine A_2A receptors in the modulation of 3-nitropropionic acid-induced striatal lesions: implications for the neuroprotective potential of A_2A antagonists.
J. Neurosci. 2003, 23, 5361-5369.
Joachim Burbiel, Mark Thorand, Christa E. Müller;
Improved, efficient synthesis for multigram-scale production of PSB-10, a potent antagonists at human A₃ adenosine receptors.
Heterocycles 2003, 60, 1425-1432.
Jens Nagel, Henning Schladebach, M. Koch, Isabel Schwienbacher, Christa E. Müller, Wolfgang Hauber;
Effects of an adenosine A_2A receptor blockade in the nucleus accumbens on locomotion, feeding, and prepulse inhibition in rats.
Synapse 2003, 49, 279-286.
Luo Yan, Joachim C. Burbiel, Astrid Maaß, Christa E. Müller;
Adenosine receptor agonists: from basic medicinal chemistry to clinical development.
Expert Opin. Emerging Drugs 2003, 8, 537-576.
Marzena Karcz-Kubicha, Katerina Antoniou, Anton Terasmaa, Davide Quarta, Marcello Solinas, Zuzana Justinova, Antonella Pezzola, Rosaria Reggio, Christa E. Müller, Kjell Fuxe, Steven R. Goldberg, Patrizia Popoli, Sergi Ferré;
Involvement of adenosine A₁ and A_2A receptors in the motor effects of caffeine after its acute and chronic administration.
Neuropsychopharmacol. 2003, 28, 1281-1291.
Marzena Karcz-Kubicha, Davide Quarta, Bruce T. Hope, Katerina Antoniou, Christa E. Müller, Marisela Morales, Charles W. Schindler, Steven R. Goldberg, Sergi Ferré;
Enabling role of adenosine A₁ receptors in adenosine A_2A receptor-mediated striatal expression of c-fos.
Eur. J. Neurosci. 2003, 18, 296-302.
H. Euler, Armin Kirfel, Alexander Bauer, Christa E. Müller;
Crystal structure of 9-benzyl-6-ethoxy-7-ethyl-2-phenyl-7,9-dihydropurin-8-one, C₂₂H₂₂N₄O₂.
Z. Kristallogr. NCS 2003, 218, 473-474.

2002

Christa E. Müller, Martina Diekmann, Mark Thorand, Vita Ozola;
[³H]8-Ethyl-4-methyl-2-phenyl-(8R)-4,5,7,8-tetrahydro-1H-imidazo[2,1-i]purin-5-one ([³H]PSB-11), a novel high-affinity antagonist radioligand for human A₃adenosine receptors.
Bioorg. Med. Chem. Lett. 2002, 12, 501-503.
Alaa M. Hayallah, Jesús Sandoval-Ramírez, Ulrike Reith,Ulrike Schobert, Birgit Preiss, Britta Schumacher, John W. Daly, Christa E. Müller;
1,8-Disubstituted xanthine derivatives: synthesis of potent A_2B-selective adenosine receptor antagonists.
J. Med. Chem. 2002, 45, 1500-1510.
Ramatullah Qurishi, Marko Kaulich, Christa E. Müller;
Fast, efficient capillary electrophoresis method for measuring nucleotide degradation and Metabolism.
J. Chromatogr. A 2002, 952, 275-281.
Karl Vollmann, Christa E. Müller;
Synthesis of 8-substituted xanthine derivatives by Suzuki cross-coupling reaction.
Heterocycles 2002, 57, 871-879.
Soon-Ai Kim, Melissa A. Marshall, Neli Melman, Hak Sun Kim, Christa E. Müller, Joel Linden, Kenneth A. Jacobson;
Structure-activity relationships at human and rat A_2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions.
J. Med. Chem. 2002, 45, 2131-2138.
Christa E. Müller, Mark Thorand, Ramatullah Qurishi, Martina Dieckmann, Kenneth A. Jacobson, William L. Padgett, John W. Daly;
Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A_2A- and A₃-adenosine receptor antagonists.
J. Med. Chem. 2002, 45, 3440-3450.
Zaida Díaz-Cabiale, Meritxell Vivó, Alberto del Arco, William T. O'Connor, Michael K. Harte, Christa E. Müller, Emili Martínez, Patrizia Popoli, Kjell Fuxe, Sergi Ferré;
Metabotropic glutamate mGlu5 receptor-mediated modulation of the ventral striatopallidal GABA pathway in rats. Interactions with adenosine A_2A and dopamine D₂ receptors.
Neurosci. Lett. 2002, 324, 154-158.
Christa E. Müller, Britta Schumacher, Axel Brattström, Ehab A. Abourashed, Uwe Koetter;
Interactions of valerian extracts and a fixed valerian-hop extract combination with adenosine receptors.
Life Sci. 2002, 71, 1939-1949.
Zhan-Guo Gao, Aishe Chen, Dov Barak, Soo-kyung Kim, Christa E. Müller, Kenneth A. Jacobson;
Identification by site-directed mutagenesis of residues involved in ligand recognition and activation of the human A₃ adenosine receptor.
J. Biol. Chem. 2002, 277, 19056-19063.
Christa E. Müller;
P2-Pyrimidinergic receptors and their ligands.
Curr. Pharm. Des. 2002, 8, 2353-2370.
Christa E. Müller, Marcus A. Hubert, Ralf Mayer;
Parkinson-Therapeutika. Teil I: Etablierte, neue und zukünftige Arzneistoffe – Struktur und Wirkungsmechanismen.
Dtsch. Apoth. Ztg. 2002, 142, 4569-4579.
Marcus A. Hubert, Ralf Mayer, Christa E. Müller;
Parkinson-Therapeutika. Teil II: Wirkstoff-Dossiers, Therapiekonzepte und pharmazeutische Betreuung.
Dtsch. Apoth. Ztg. 2002, 142, 4708-4717.
Katarzyna Kieć-Kononowicz, Christa E. Müller, Elzbieta Pękala, Janina Karolak-Wojciechowska, J. Handzlik, D. Łażewska;
Imidazo[2,1-b]thiazoles, imidazo[2,1-b]imidazoles, and pyrrolo[1,2-c]imidazoles. Synthesis, structure and evaluation of benzodiazepine receptor binding.
J. Heterocyclic Chem. 2002, 38, 243-253.
Britta Schumacher,Silke Scholle, Josef Hölzl,Nasser Khudeir,Sonja Hess, Christa E. Müller;
Lignans isolated from valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A₁ adenosine receptors.
J. Nat. Prod. 2002, 65, 1479-1485.
H. Euler, Armin Kirfel, Sven Jan Freudenthal, Christa E. Müller;
Crystal structure of 4-bromobutyric acid 3-((4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacen)-8-yl)propyl ester, C₂₀H₂₆BBrF₂N₂O₂.
Z. Kristallogr. NCS 2002, 217, 541-542.
H. Euler, Armin Kirfel, Sven Jan Freudenthal, Christa E. Müller;
Crystal structure of 8-(5-bromopentyl)-4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene, C₁₈H₂₄BBrF₂N₂.Z. Kristallogr. NCS 2002, 217, 543-545.

2001

Christa E. Müller;
A₁ Adenosine receptors and their ligands: overview and recent developments.
Il Farmaco 2001, 56, 77-80.
Sergi Ferré, Patrizia Popoli, L. Giménez-Llort, R. Rimondini, Christa E. Müller, Ingrid Strömberg, Sven O. Ögren, Kjell Fuxe;
Adenosine/dopamine interaction: implication for the treatment of Parkinson's disease.
Parkinsonism and Related Disorders 2001, 7, 235-241.
Katarzyna Kieć-Kononowicz, Janina Karolak-Wojciechowska, Christa E. Müller, Britta Schumacher, Elżbieta Pękala, Ewa Szymanska;
Imidazothiazine, -diazinone and -diazepinone derivatives. Synthesis, structure and benzodiazepine receptor binding.
Eur. J. Med. Chem., 2001, 36, 407-419.
Christa E. Müller;
A₃ Adenosine receptor antagonists;
Mini-Rev. Med. Chem. 2001, 1, 417-427.
Wolfgang Hauber, Patric Neuscheler, Jens Nagel, Christa E. Müller;
Catalepsy induced by a blockade of dopamine D₁ or D₂ receptors was reversed by a concomitant blockade of A_2A receptors in the caudate-putamen of rats.
Eur. J. Neurosci. 2001, 14, 1287-1293.
Zhan-Guo Gao, Jacqueline E. van Muijlwijk-Koezen, Aishe Chen, Christa E. Müller, Adriaan P. IJzerman, Kenneth A. Jacobson;
Allosteric modulation of A₃ adenosine receptors by a series of 3-(2-pyridinyl)isoquinoline derivatives.
Mol. Pharmacol. 2001, 60, 1057-1063.
Katarzyna Kieć-Kononowicz, A. Drabczyńska, Elzbieta Pękala, B. Michalak, Christa E. Müller, Britta Schumacher, Janina Karolak-Wojciechowska, H. Duddeck, S. Rockitt, R. Wartchow;
New developments in A₁ and A₂ adenosine receptor antagonists.
Pure Appl. Chem. 2001, 73, 1411-1420.

2000 - 1989

2000

Roland Sauer, Juris Maurinsh, Ulrike Reith, Friederike Fülle, Karl-Norbert Klotz, Christa E. Müller;
Water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, A_2A-selective adenosine receptor antagonists.
J. Med. Chem. 2000, 43, 440-448.
Friederike Fülle, Christa E. Müller;
A novel ring closure reaction for the preparation of 6-aminouracils with an a-branched 1-substituent.
Heterocycles, 2000, 53, 347-351.
Christa E. Müller, Juris Maurinsh, Roland Sauer;
Binding of [³H]MSX-2 (3-(3-hydroxypropyl)-7-methyl-8-(m-methoxystyryl)-1-propargylxanthine) to rat striatal membranes - a new, selective antagonist radioligand for A_2A adenosine receptors.
Eur. J. Pharm. Sci. 2000, 10, 259-265.
Antje Harms, Daniela Gündisch, Christa E. Müller, Karl-Artur Kovar;
Development of a 5-hydroxytryptamine 5-HT_2A receptor binding assay for high throughput screening using 96-Well microfilter plates.
J. Biomol. Screening 2000, 5, 269-277.
Ingrid Strömberg, Patrizia Popoli, Christa E. Müller, Sergi Ferré, Kjell Fuxe;
Electrophysiological and behavioral evidence for an antagonistic modulatory role of adenosine A_2A receptors in dopamine D₂ receptor regulation in the rat dopamine denervated striatum.
Eur. J. Neurosci. 2000, 12, 4033-4037.
Sonja Hess, Christa E. Müller, Wolfram Frobenius, Ulrike Reith, Karl-Norbert Klotz, Kurt Eger
7-deazaadenines bearing polar substituents: structure-activity relationships of new A₁ and A₃ adenosine receptor antagonists.
J. Med. Chem. 2000, 43, 4636-4646.
Christa E. Müller;
Adenosine receptor ligands – recent developments. Part I. Agonists.
Curr. Med. Chem. 2000, 7, 1269-1288.
Christa E. Müller;
A_2A Adenosine receptor antagonists – future drugs for Parkinson's disease?
Drugs of the Future, 2000, 25, 1043-1052.

1999-1998

Bernd H. A. Knoblauch, Christa E. Müller, Leif Järlebark, Grace Lawoko, Thomas Kottke, Martin A. Wikström, Edith Heilbronn;
5-Substituted UTP derivatives as P2Y₂ receptor agonists.
Eur. J. Med. Chem. 1999, 34, 809-824.
Christa E. Müller;
Basic chemistry of 2-nitroimidazoles (azomycin derivatives).
In: Machulla, H.-J. (Hrsg.), Hypoxia Imaging. Kluwer Academic Publishers, Dordrecht, Boston, London, 1999.
Katarzyna Kieć-Kononowicz, Janina Karolak-Wojciechowska, Christa E. Müller, Uli Geis, Waldemar Ksiazek, Ewa Szymanska;
Arylidene imidazothiazoles. Synthesis, structure and benzodiazepine receptor binding.
J. Heterocyclic Chemistry 1998, 36, 257-263.
Christa E. Müller, Roland Sauer, Yuris Maurinsh, Rosa Huertas, Friederike Fülle, Karl-Norbert Klotz, Jens Nagel, Wolfgang Hauber;
A_2A-Selective adenosine receptor antagonists: development of water-soluble prodrugs and a new tritiated radioligand.
Drug Dev. Res. 1998, 45, 190-197
Christa E. Müller, Ingrid Müller;
Neue Migräne-Therapeutika im Überblick.
Pharm. Unserer Zeit, 1998, 27, 209-215.
Christa E. Müller, Dirk Deters, Andreas Dominik;
Syntheses of paraxanthine and isoparaxanthine analogs (1,7- and 1,9-Substituted Xanthine Derivatives).
Synthesis 1998, 1428-1436.
Barbara Matuszczak, Elsbieta Pekala, Christa E. Müller;
1-Substituted 4-[chloropyrazolyl][1,2,4]triazolo[4,3-a]quinoxalines: synthesis and structure-activity relationships of a new class of benzodiazepine and adenosine receptor ligands.
Arch. Pharm. Pharm. Med. Chem. 1998, 331, 163-169.
Christa E. Müller, Jesús Sandoval-Ramírez, Ulrike Schobert, Uli Geis, Wolfram Frobenius, Karl-Norbert Klotz;
8-(Sulfostyryl)xanthines: water-soluble A_2A-selective adenosine receptor antagonists.
Bioorg. Med. Chem. 1998, 6, 707-719.
Wolfgang Hauber, Jens Nagel, Roland Sauer, Christa E. Müller;
Motor effects induced by a blockade of adenosine A_2A receptors in the caudate-putamen.
Neuroreport 1998, 9, 1803-1806.
Hermann J. Roth, Christa E. Müller, Gerd Folkers;
Stereochemie & Arzneistoffe. Grundlagen - Betrachtungen - Auswirkungen. (Lehrbuch)
Wissenschaftliche Verlagsgesellschaft Stuttgart 1998 (ISBN 3-8047-1485-4).
Claudia Eder, Peter Schupp, Peter Proksch, Victor Wray, Klaus Steube, Christa E. Müller, Wolfram Frobenius, Markus Herderich, Rob W. M. van Soest;
Bioactive pyridoacridine alkaloids from the Micronesian sponge Oceanapia sp.
J. Nat. Prod. 1998, 61, 301-305.
Bernd H. A. Knoblauch, U. Köster, Christa E. Müller, F. Möller;
Crystal structure of 6-amino-3-(2',3',5'-tri-O-benzoyl-b-D-ribofuranosyl)-2,4(1H)-pyrimidinedione, C₃₁H₂₉N₃O₁₀
Z. Kristallogr. NCS 1998, 213, 145-146.
Bernd H. A. Knoblauch, U. Köster, Christa E. Müller, F. Möller;
Crystal structure of 5-ethyl-1-(2',3',5'-tri-O-benzoyl-b-D-ribofuranosyl)-2,4(3H)-
pyrimidinedione, C₃₂H₂₈N₂O₉
Z. Kristallogr. NCS 1998, 213, 143-144.
Armin Kirfel, F. Schwabenländer, Christa E. Müller;
Crystal structure of 6-amino-3-methyl-5-nitrosopyrimidine-2,4(1H,3H)-dione monosodium dihydrate, C₅H₅N₄O₃Na 2H₂O;
Z. Kristallogr. NCS 1998, 213, 141-142.
Christa E. Müller;
Xanthine - Renaissance einer altbekannten Naturstoffklasse.
In: Pichler, H. (Hrsg.) Zwischen Wissenschaft und Kunst. Hermann Josef Roth - Portrait eines nicht nur wissenschaftlichen Lebens. ISBN: 978-3-7692-2212-8
Deutscher Apotheker Verlag, Stuttgart 1998, S. 73-88.

1997 - 1994

Christa E. Müller, Uli Geis, Jo Hipp, Ulrike Schobert, Wolfram Frobenius, Maciej Pawłowski, Fumio Suzuki, Jesús Sandoval-Ramírez;
Synthesis and structure-activity relationships of DMPX (3,7-dimethyl-1-propargyl‑xanthine) derivatives, A_2A-selective adenosine receptor antagonists.
J. Med. Chem. 1997, 40, 4396-4405.
Armin Kirfel, F. Schwabenländer, Christa E. Müller
Crystal structure of 1-propyl-8-(4-sulfophenyl)-7H-imidazo[4,5-d]pyrimidin-2,6(1H,3H)-dione dihydrate, C₁₄H₁₄N₄O₅S x 2 H₂O
Z. Kristallographie - New Cryst. Struct. 1997, 3, 447-448.
Christa E. Müller, Ulrike Schobert, Jo Hipp, Uli Geis, Wolfram Frobenius, Maciej Pawłowski;
Configurationally stable analogs of 8-styrylxanthines as A_2A-adenosine receptor antagonists.
Eur. J. Med. Chem. 1997, 32, 709-719.
Edith Heilbronn, Bernd H.A. Knoblauch, Christa E. Müller;
Uridine nucleotide receptors and their ligands: structural, physiological, and pathophysiological aspects, with special emphasis on the nervous system.
Neurochem. Res. 1997, 22, 1041-1050.
Christa E. Müller;
A₁-Adenosine receptor antagonists.
Exp. Opin. Ther. Patents 1997, 7, 419-440.
Christa E. Müller, Roland Sauer, Uli Geis, Wolfram Frobenius, Przemysław Talik, Maciej Pawłowski;
Aza-analogs of 8-styrylxanthines as A_2A-adenosine receptor antagonists.
Arch. Pharm. Pharm. Med. Chem. 1997, 330, 181-189.
Christa E. Müller, Birgitt Stein;
Adenosine receptor antagonists: structures and potential therapeutic applications.
Curr. Pharm. Des. 1996, 2, 501-530.
Uli Geis, Katarzyna Kieć-Kononowicz, Christa E. Müller;
Benzylidine-substituted imidazo-thiazole, -thiazine and -thiazepine derivatives: a new class of ligands for the benzodiazepine binding site of GABA_A receptors.
Sci. Pharm. 1996, 64, 383-390.
Christa E. Müller, Uli Geis, Bettina Grahner, Wolfgang Lanzner, Kurt Eger;
Chiral pyrrolo[2,3-d]pyrimidine and pyrimido[4,5-b]indole derivatives: structure-activity relationships of potent, highly stereoselective A₁-adenosine receptor antagonists.
J. Med. Chem. 1996, 39, 2482-2491.
Christa E. Müller;
Epibatidin - ein nicotinartiges, analgetisch wirksames Alkaloid aus Pfeilgiftfröschen.
Pharm. Unserer Zeit 1996, 25, 85-92.
Christa E. Müller, Jesús Sandoval-Ramírez;
A new versatile synthesis of xanthines with variable substituents in the 1-, 3-, 7-, and 8‑positions.
Synthesis 1995, 1295-1299.
Christa E. Müller;
Nicotin - vom Genußmittel zum Arzneistoff?
Dtsch. Apoth. Ztg. 1995, 135, 3253-3268.
Uli Geis, Bettina Grahner, Maciej Pawłowski, Anna Drabczynska, Maria Gorczyca, Christa E. Müller;
Tricyclic theophylline derivatives with high water-solubility: structure-activity relationships at adenosine receptors, phosphodiesterases and benzodiazepine binding sites.
Pharmazie 1995, 50, 333-336.
Christa E. Müller, Bettina Grahner, Dieter Heber;
Amino-substituted 1,8-naphthyridines and pyrido[2,3-d]pyrimidines: new compounds with affinity for A₁- and A₂-adenosine receptors.
Pharmazie 1994, 49, 878-880.
Bettina Grahner, Susanne Winiwarter, Wolfgang Lanzner, Christa E. Müller;
Synthesis and structure-activity relationships of deazaxanthines - analogs of potent A₁- and A₂-adenosine receptor antagonists.
J. Med. Chem. 1994, 37, 1526-1534.
Christa E. Müller;
Formation of oxazolo[3,2-a]purinones from propynyluracils.
J. Org. Chem. 1994, 59, 1928-1929.
Christa E. Müller;
Barbitursäurederivate und verwandte Stoffe.
Hager's Handbuch der Pharmazeutischen Praxis, 5. Auflage,
v. Bruchhausen, G. Dannhardt, S. Ebel, A. W. Frahm, E. Hackenthal und U. Holzgrabe (Hrsg.); Bände 8 und 9: Stoffe, 26 Monographien; Springer Verlag Heidelberg, 1994.
Christa E. Müller;
Formation of 7,9-disubstituted xanthinium compounds under mild conditions by alkylation of silylated xanthines.
Synth. Commun. 1994, 24, 1311-1315.

1993-1989

Christa E. Müller, John W. Daly;
Stimulation of calcium release by caffeine analogs in pheochromocytoma cells.
Biochem. Pharmacol. 1993, 46, 1825-1829.
Christa E. Müller, Dan Shi, Malcolm Manning Jr., John W. Daly;
Synthesis of paraxanthine analogs (1,7-disubstituted xanthines) and other xanthines unsubstituted at the 3-position: structure-activity relationships at adenosine receptors.
J. Med. Chem. 1993, 36, 3341-3349.
Christa E. Müller, Tom Scior;
Adenosine receptors and their modulators.
Pharm. Acta Helv. 1993, 68, 77-111.
Kenneth A. Jacobson, Dan Shi, Carola Gallo-Rodriguez, Malcolm Manning Jr., Christa E. Müller, John W. Daly, John L. Neumeyer, Leonidas Kiriasis, Wolfgang Pfleiderer;
Effect of trifluoromethyl- and other substituents on activity of xanthines at adenosine receptors.
J. Med. Chem. 1993, 36, 2639-2644.
Christa E. Müller;
Synthesis and properties of 1-monosubstituted xanthines.
Synthesis 1993, 125-128.
Christa E. Müller;
Synthesis of 3-substituted 6-aminouracils.
Tetrahedron Lett. 1991, 32, 6539-6540.
John W. Daly, Izumi Hide, Christa E. Müller, Mah Shamim;
Caffeine analogs: structure-activity relationships at adenosine receptors.
Pharmacology 1991, 42, 309-321.
Hydar Ali, Christa E. Müller, John W. Daly, Michael Beaven;
Methylxanthines block antigen-induced responses in RBL-2H3 cells independently of adenosine receptors and cyclic AMP: evidence for inhibition of antigen binding to IgE
J. Pharm. Exp. Therap. 1991, 258, 954-962.
Christa E. Müller, Izumi Hide, John W. Daly, Klaus Rothenhäusler, Kurt Eger;
7-Deaza-2-phenyladenines - structure-activity relationships of potent A₁ selective adenosine receptor antagonists.
J. Med. Chem. 1990, 33, 2822-2828.
Christa E. Müller, Herrmann J. Roth;
A new synthesis of thiophosphoric acid esters with a C-S-P bond.
Tetrahedron Lett. 1990, 31, 501-502.
Christa E. Müller, Gerd Folkers;
Adenosinrezeptor-Liganden - Arzneistoffe der Zukunft?
Pharm. Unserer Zeit 1989, 18, 65-75.
Peter T. Daniel, Joachim Holzschuh, Christa E. Müller, Hermann J. Roth, Peter A. Berg;
Inhibition of phytohemagglutinine-induced T lymphocyte proliferation by 6-(octadecyldithio)purine, a novel liposomal prodrug of 6-mercaptopurine.
Arch. Toxicol. Suppl. 1989, 13, 179-182.
Christa E. Müller, Peter T. Daniel, Joachim Holzschuh, Hermann J. Roth;
Lipophilic disulfide prodrugs - syntheses and disulfide bond cleavage.
Int. J. Pharm. 1989, 57, 41-47.
Christa E. Müller, Hermann J. Roth;
Amphiphile unsymmetrische Disulfide als Liposomenbausteine.
Arch. Pharm. (Weinheim) 1989, 322, 342-350.
Gerd Folkers, Gerlinde Junginger, Christa E. Müller, Ulrich Schloz, Kurt Eger;
Synthese Computergraphik berechneter high-anti-fixierter Pyrimidin-Nucleosid-Analoga mit potentieller virostatischer und antineoplastischer Wirksamkeit.
Arch. Pharm. (Weinheim) 1989, 322, 119-123.

Patents and Patent Applications

2023 - 2020

P20.

Christa E. Müller et al.;

Glycine derivatives with P2X4 receptor-blocking activity for the treatment of pain, inflammation, cancer, and other P2X4 receptor-related diseases.

Rheinische Friedrich-Wilhelms-Universität Bonn

EP22214883.5 (application number), submitted 2022.

P19.

Wessam Alnouri, Jörg Hockemeyer, Daniel Marx, Christa E. Müller,* Vigneshwaran Namasivayam, Yvonne Riedel, Dominik Thimm, Sophie Clemens, Robin Gedschold, Thanigaimalai Pillaiyar; (*main inventor)

3-Substituted xanthine derivatives as MRGPRX4 receptor modulators.

Rheinische Friedrich-Wilhelms-Universität Bonn

WO 2022/079245 A1.

P18.

Christa Müller, Mohamad Wessam Alnouri, Yvonne Riedel, Dominik Thimm, Daniel Marx, Vigneshwaran Namasivayam, Susanne Gattner, Piet Herdewyn, Steven De Jonghe, Piotr Leonczak, Sven Verdonck;

MRGX receptor antagonists.

Rheinische Friedrich-Wilhelms-Universität Bonn; Katholieke Universiteit Leuven

US20210128561A.

P17.

Kenneth A. Jacobson, Anna Junker, Mirko Scortichini, Clemens Dobelmann, Christian R. Renn, Vigneshwaran Namasivayam, Riham M. Idris, Christa E. Müller;

Purine and pyrimidine nucleotides as ecto-5’-nucleotidase inhibitors.

NIH, USA; University of Bonn; University of Münster

PCT Int. Appl. 2020, WO 2020037275 A1.

P16.

Hana Bilha Fischer, Molhm Nassir, Vadim Zelikman, Uri Moshe Arad, Jean Sevigny, Christa E. Müller;

Highly selective and potent NPP1 inhibitors based on uridine-5’-Pa,a-dithiophosphate analogues.

Bar-Ilan University, Ichilov Tech Ltd., Laval University, University of Bonn

WO2020/212995 A1.

P15.

Cécile Pegurier, Silvia Lovera, Christa E. Müller, Joerg Hockemeyer, Mahmoud Rashed, Ali El-Tayeb, Yong-Qiang Zhang;

N-Phenyl-indole-3-sulfonamide derivatives and related compounds as GPR17 modulators for treating CNS disorders such as multiple sclerosis.

UCB Pharma GmbH

WO2020/254289 A1; EP-3983384-A1; CN-113993845-A; CA3137091A1; JP2022537103A etc.

2019 - 2010

P14.

Cécile Pegurier, Laurent Provis, Alvaro Cardenas, Marie Ledecq, Christa E. Müller, Jörg Hockemeyer, Ali El-Tayeb, Nader Boshta, Mahmoud Rashed;

Pyridinyl- and pyrazinyl-(aza)indolesulfonamides.

UCB Pharma GmbH

PCT Int. Appl. 2019, WO2019/243303 A1 20191226

P13.

Christa E. Mueller, Cecile Pegurier, Michael Louis Robert Deligny, Ali El-Tayeb, Joerg Hockenmeyer, Marie Ledecq, Joel Mercier, Laurent Provins, Nader M. Boshta, Sanjay Bhattarai, Vigneshwaran Namasivayam, Mario Funke, Lukas Schwach, Sabrina Gollos, Daniel Von Laufenberg, Anais Barre;

(Aza)indole-, Benzothiophene-, and benzofuran-3-sulfonamides.

PCT Int. Appl. 2018, WO/2018/122232 A1.

P12.

Evi Kostenis, Andreas Spinrath, Stephanie Hennen, Lukas Peters, Christa E. Müller, Rhalid Akkari, Younis Baqi, Kirsten Ritter;
GPR17 agonists and screening assay.
United States Patent 2014, US8,623,593 B1.
Evi Kostenis, Andreas Spinrath, Stephanie Hennen, Lukas Peters, Christa E. Müller, Rhalid Akkari, Younis Baqi, Kirsten Ritter;
GPR17 agonists and screening assay.
European Patent 2014, EP2,567,698 B1.
Evi Kostenis, Andreas Spinrath, Stephanie Hennen, Lukas Peters, Christa E. Müller, Rhalid Akkari, Younis Baqi, Kirsten Ritter;
Methods of identifying modulators of GPR17.
United States Patent 2013, US8,404,436 B1.

P11.

Christa E. Müller, Andreas Zimmer, Stefanie Labs, Stephanie Töpffer, Sonja Hinz;
8-Triazolylxanthine derivatives, processes for their production and their use as adenosine A_2B receptor antagonists.
Eur. Pat. Appl. 2012, EP2465859 A1.

P10.

Christa E. Müller, Jörg Hockemeyer, Nikolay T. Tzvetkov, Joachim C. Burbiel;

8-Alkynylxanthines and derivatives.

UCB Pharma GmbH
US Patent 2011, US 8044061 B2.

P9.

Christa E. Müller, Thomas Borrmann, Aliaa Abdelrahman;
Adenine receptor ligands.
Eur. Pat. Appl. 2010, EP 2141166 A1.

2009 - 2000

P8.

Christa. E. Müller, Jörg Hockemeyer, Nikolay T. Tzvetkov, Joachim C. Burbiel;
Preparation of 8-ethynyl-xanthine derivatives as selective A_2A receptor antagonists. (Schwarz Pharma AG, Germany).
PCT Int. Appl. 2008, WO 2008077557 A1.

P7.

Younis Baqi, Christa E. Müller;
Novel P2Y₁₂ receptor antagonists.
PCT Int. Appl. 2008, WO 2008107211 A2.

P6.

Christa E. Müller, Andreas Brunschweiger, Jamshed Iqbal;
Preparation of nucleotide mimetics as ectonucleotidase inhibitors.
Eur. Pat. Appl. 2007, EP 1860113 A1 20071108.

P5.

Rafael Franco Fernàndez, Francisco Ciruela Alferez, Carmen Lluis Biset, Christa E. Müller, Joan Cinca Cuscullola, Leif Hove-Madsen;
Compounds for the treatment of auricular fibrillation.
PCT Int. Appl. 2007, WO 2007045705 A2.

P4.

Jürgen Schrader, Christa E. Müller, Ali El-Tayeb, Jamshed Iqbal;
Preparation of phosphorylated nucleosides as A_2A receptor agonists.
PCT Int. Appl. 2007, WO 2007107598 A1.

P3.

Barbara Matuszczak, Christa E. Müller;
Preparation of triazoloquinoxalines as human A₁, A_2A, A_2b and A₃ adenosine receptor ligands.
PCT Int. Appl. 2003, WO 2003053973 A1.

1999 - 1989

P2.

Kurt Eger, Gerd Folkers, Hermann J. Roth, Christa E. Müller, Gerlinde Junginger, Ulrich Schloz;
Preparation of 2,2’-anhydropyrimidine nucleosides as virustatic and cytostatic agents, and antibacterials and pharmaceuticals containing them.
Ger. Offen. 1989, DE 3727902 A1.

P1.

Hermann J. Roth, Christa E. Müller;
Preparation of disulfide-linked amphiphiles as drugs.
Ger. Offen. 1989, DE 3728917 A1.