© Volker Lannert

Working Group Hansen

Methods

1/12 © Arbeitskreis Hansen

2/12 © Arbeitskreis Hansen

3/12 © Volker Lannert

4/12 © Volker Lannert

5/12 © Volker Lannert

6/12 © Volker Lannert

7/12 © Volker Lannert

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9/12 © Volker Lannert

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12/12 © Volker Lannert

© Volker Lannert

Synthesis of drug molecules

Medicinal chemistry
Microwave-assisted synthesis
Solid-phase synthesis
Combinatorial synthesis
Multi-component reactions
Compound classes: e.g. small molecules, peptides, peptidomimetics, PROTACs

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© Volker Lannert

Target Engagement Assays

Biochemical enzyme assays
Jump dilution assays
NanoBiT assays
CETSA
Western Blot
Microscale Thermophoresis (MST) assays

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© Volker Lannert

Cell biological characterization of drug molecules

Viability assays (MTT, WST-8, and Celltiter Glo)
Cell cycle analysis
Functional apoptosis assays (Annexin V/PI, Caspase 3/7)

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© Dr. Kathrin Tan

Molecular Modeling

Docking studies using Gold, MOE, RosettaLigand, and Autodock

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